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Residential exposure to transportation noise and risk of incident atrial fibrillation : a pooled study of 11 prospective Nordic cohorts

Thacher, Jesse D LU ; Roswall, Nina ; Ögren, Mikael ; Pyko, Andrei LU ; Åkesson, Agneta ; Oudin, Anna LU ; Rosengren, Annika ; Poulsen, Aslak H ; Eriksson, Charlotta and Segersson, David , et al. (2024) In The Lancet regional health. Europe 46. p.1-12
Abstract

BACKGROUND: Transportation noise has been linked with cardiometabolic outcomes, yet whether it is a risk factor for atrial fibrillation (AF) remains inconclusive. We aimed to assess whether transportation noise was associated with AF in a large, pooled Nordic cohort.

METHODS: We pooled data from 11 Nordic cohorts, totaling 161,115 participants. Based on address history from five years before baseline until end of follow-up, road, railway, and aircraft noise was estimated at a residential level. Incident AF was ascertained via linkage to nationwide patient registries. Cox proportional hazards models were utilized to estimate associations between running 5-year time-weighted mean transportation noise (L
den) and AF after... (More)

BACKGROUND: Transportation noise has been linked with cardiometabolic outcomes, yet whether it is a risk factor for atrial fibrillation (AF) remains inconclusive. We aimed to assess whether transportation noise was associated with AF in a large, pooled Nordic cohort.

METHODS: We pooled data from 11 Nordic cohorts, totaling 161,115 participants. Based on address history from five years before baseline until end of follow-up, road, railway, and aircraft noise was estimated at a residential level. Incident AF was ascertained via linkage to nationwide patient registries. Cox proportional hazards models were utilized to estimate associations between running 5-year time-weighted mean transportation noise (L
den) and AF after adjusting for sociodemographics, lifestyle, and air pollution.

FINDINGS: We identified 18,939 incident AF cases over a median follow-up of 19.6 years. Road traffic noise was associated with AF, with a hazard ratio (HR) and 95% confidence interval (CI) of 1.02 (1.00-1.04) per 10-dB of 5-year mean time-weighted exposure, which changed to 1.03 (1.01-1.06) when implementing a 53-dB cut-off. In effect modification analyses, the association for road traffic noise and AF appeared strongest in women and overweight and obese participants. Compared to exposures ≤40 dB, aircraft noise of 40.1-50 and > 50 dB were associated with HRs of 1.04 (0.93-1.16) and 1.12 (0.98-1.27), respectively. Railway noise was not associated with AF. We found a HR of 1.19 (1.02-1.40) among people exposed to noise from road (≥45 dB), railway (>40 dB), and aircraft (>40 dB) combined.

INTERPRETATION: Road traffic noise, and possibly aircraft noise, may be associated with elevated risk of AF.

FUNDING: NordForsk.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Lancet regional health. Europe
volume
46
article number
101091
pages
1 - 12
publisher
Elsevier
external identifiers
  • scopus:85205322497
  • pmid:39403081
ISSN
2666-7762
DOI
10.1016/j.lanepe.2024.101091
language
English
LU publication?
yes
additional info
© 2024 The Author(s).
id
6e9218f7-c1c3-4052-bf81-29eed8cd34f1
date added to LUP
2024-12-04 11:34:47
date last changed
2025-01-30 08:57:30
@article{6e9218f7-c1c3-4052-bf81-29eed8cd34f1,
  abstract     = {{<p>BACKGROUND: Transportation noise has been linked with cardiometabolic outcomes, yet whether it is a risk factor for atrial fibrillation (AF) remains inconclusive. We aimed to assess whether transportation noise was associated with AF in a large, pooled Nordic cohort.</p><p>METHODS: We pooled data from 11 Nordic cohorts, totaling 161,115 participants. Based on address history from five years before baseline until end of follow-up, road, railway, and aircraft noise was estimated at a residential level. Incident AF was ascertained via linkage to nationwide patient registries. Cox proportional hazards models were utilized to estimate associations between running 5-year time-weighted mean transportation noise (L<br>
 den) and AF after adjusting for sociodemographics, lifestyle, and air pollution.<br>
 </p><p>FINDINGS: We identified 18,939 incident AF cases over a median follow-up of 19.6 years. Road traffic noise was associated with AF, with a hazard ratio (HR) and 95% confidence interval (CI) of 1.02 (1.00-1.04) per 10-dB of 5-year mean time-weighted exposure, which changed to 1.03 (1.01-1.06) when implementing a 53-dB cut-off. In effect modification analyses, the association for road traffic noise and AF appeared strongest in women and overweight and obese participants. Compared to exposures ≤40 dB, aircraft noise of 40.1-50 and &gt; 50 dB were associated with HRs of 1.04 (0.93-1.16) and 1.12 (0.98-1.27), respectively. Railway noise was not associated with AF. We found a HR of 1.19 (1.02-1.40) among people exposed to noise from road (≥45 dB), railway (&gt;40 dB), and aircraft (&gt;40 dB) combined.</p><p>INTERPRETATION: Road traffic noise, and possibly aircraft noise, may be associated with elevated risk of AF.</p><p>FUNDING: NordForsk.</p>}},
  author       = {{Thacher, Jesse D and Roswall, Nina and Ögren, Mikael and Pyko, Andrei and Åkesson, Agneta and Oudin, Anna and Rosengren, Annika and Poulsen, Aslak H and Eriksson, Charlotta and Segersson, David and Rizzuto, Debora and Helte, Emilie and Andersson, Eva M and Aasvang, Gunn Marit and Engström, Gunnar and Gudjonsdottir, Hrafnhildur and Selander, Jenny and Christensen, Jesper H and Brandt, Jørgen and Leander, Karin and Overvad, Kim and Mattisson, Kristoffer and Eneroth, Kristina and Stucki, Lara and Barregard, Lars and Stockfelt, Leo and Albin, Maria and Simonsen, Mette K and Raaschou-Nielsen, Ole and Jousilahti, Pekka and Tiittanen, Pekka and Ljungman, Petter L S and Jensen, Steen S and Gustafsson, Susanna and Yli-Tuomi, Tarja and Cole-Hunter, Thomas and Lanki, Timo and Lim, Youn-Hee and Andersen, Zorana J and Pershagen, Göran and Sørensen, Mette}},
  issn         = {{2666-7762}},
  language     = {{eng}},
  pages        = {{1--12}},
  publisher    = {{Elsevier}},
  series       = {{The Lancet regional health. Europe}},
  title        = {{Residential exposure to transportation noise and risk of incident atrial fibrillation : a pooled study of 11 prospective Nordic cohorts}},
  url          = {{http://dx.doi.org/10.1016/j.lanepe.2024.101091}},
  doi          = {{10.1016/j.lanepe.2024.101091}},
  volume       = {{46}},
  year         = {{2024}},
}