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Associations between dietary patterns and dementia-related neuroimaging markers

Samuelsson, Jessica ; Marseglia, Anna LU ; Lindberg, Olof ; Westman, Eric ; Pereira, Joana B. LU ; Shams, Sara ; Kern, Silke ; Ahlner, Felicia ; Rothenberg, Elisabet and Skoog, Ingmar , et al. (2023) In Alzheimer's and Dementia 19(10). p.4629-4640
Abstract

BACKGROUND: The exploration of associations between dietary patterns and dementia-related neuroimaging markers can provide insights on food combinations that may impact brain integrity. METHODS: Data were derived from the Swedish Gothenburg H70 Birth Cohort Study (n = 610). Three dietary patterns were obtained using principal component analysis. Magnetic resonance imaging markers included cortical thickness, an Alzheimer's disease (AD) signature score, small vessel disease, and white matter microstructural integrity. Adjusted linear/ordinal regression analyses were performed. RESULTS: A high-protein and alcohol dietary pattern was negatively associated with cortical thickness in the whole brain (Beta: −0.011; 95% confidence interval... (More)

BACKGROUND: The exploration of associations between dietary patterns and dementia-related neuroimaging markers can provide insights on food combinations that may impact brain integrity. METHODS: Data were derived from the Swedish Gothenburg H70 Birth Cohort Study (n = 610). Three dietary patterns were obtained using principal component analysis. Magnetic resonance imaging markers included cortical thickness, an Alzheimer's disease (AD) signature score, small vessel disease, and white matter microstructural integrity. Adjusted linear/ordinal regression analyses were performed. RESULTS: A high-protein and alcohol dietary pattern was negatively associated with cortical thickness in the whole brain (Beta: −0.011; 95% confidence interval [CI]: −0.018 to −0.003), and with an Alzheimer's disease cortical thickness signature score (Beta: −0.013; 95% CI: −0.024 to −0.001). A positive association was found between a Mediterranean-like dietary pattern and white matter microstructural integrity (Beta: 0.078; 95% CI: 0.002–0.154). No associations were found with a Western-like dietary pattern. DISCUSSION: Dietary patterns may impact brain integrity through neurodegenerative and vascular pathways. Highlights: Certain dietary patterns were associated with dementia-related neuroimaging markers. A Mediterranean dietary pattern was positively associated with white matter microstructure. A high-protein and alcohol pattern was negatively associated with cortical thickness.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, dementia, dietary patterns, diffusion tensor imaging, magnetic resonance imaging, neuroimaging
in
Alzheimer's and Dementia
volume
19
issue
10
pages
4629 - 4640
publisher
Wiley
external identifiers
  • scopus:85150971703
  • pmid:36960849
ISSN
1552-5260
DOI
10.1002/alz.13048
language
English
LU publication?
yes
id
737b72f4-aec0-453a-b02b-01da02aa1e29
date added to LUP
2023-05-24 14:16:29
date last changed
2024-05-18 01:45:32
@article{737b72f4-aec0-453a-b02b-01da02aa1e29,
  abstract     = {{<p>BACKGROUND: The exploration of associations between dietary patterns and dementia-related neuroimaging markers can provide insights on food combinations that may impact brain integrity. METHODS: Data were derived from the Swedish Gothenburg H70 Birth Cohort Study (n = 610). Three dietary patterns were obtained using principal component analysis. Magnetic resonance imaging markers included cortical thickness, an Alzheimer's disease (AD) signature score, small vessel disease, and white matter microstructural integrity. Adjusted linear/ordinal regression analyses were performed. RESULTS: A high-protein and alcohol dietary pattern was negatively associated with cortical thickness in the whole brain (Beta: −0.011; 95% confidence interval [CI]: −0.018 to −0.003), and with an Alzheimer's disease cortical thickness signature score (Beta: −0.013; 95% CI: −0.024 to −0.001). A positive association was found between a Mediterranean-like dietary pattern and white matter microstructural integrity (Beta: 0.078; 95% CI: 0.002–0.154). No associations were found with a Western-like dietary pattern. DISCUSSION: Dietary patterns may impact brain integrity through neurodegenerative and vascular pathways. Highlights: Certain dietary patterns were associated with dementia-related neuroimaging markers. A Mediterranean dietary pattern was positively associated with white matter microstructure. A high-protein and alcohol pattern was negatively associated with cortical thickness.</p>}},
  author       = {{Samuelsson, Jessica and Marseglia, Anna and Lindberg, Olof and Westman, Eric and Pereira, Joana B. and Shams, Sara and Kern, Silke and Ahlner, Felicia and Rothenberg, Elisabet and Skoog, Ingmar and Zettergren, Anna}},
  issn         = {{1552-5260}},
  keywords     = {{Alzheimer's disease; dementia; dietary patterns; diffusion tensor imaging; magnetic resonance imaging; neuroimaging}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{4629--4640}},
  publisher    = {{Wiley}},
  series       = {{Alzheimer's and Dementia}},
  title        = {{Associations between dietary patterns and dementia-related neuroimaging markers}},
  url          = {{http://dx.doi.org/10.1002/alz.13048}},
  doi          = {{10.1002/alz.13048}},
  volume       = {{19}},
  year         = {{2023}},
}