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The water-perfusable tissue fraction of colorectal cancer metastases is increased by the selective PDGF-receptor inhibitor imatinib but not the IL-1 receptor antagonist anakinra, a study using serial dynamic 15O-water PET.

Lubberink, Mark ; Golla, Sandeep S V ; Jonasson, My ; Rubin, Kristofer LU ; Glimelius, Bengt ; Sörensen, Jens and Nygren, Peter (2015) In Journal of Nuclear Medicine 56(8). p.1144-1149
Abstract
High interstitial fluid pressure (IFP) in colorectal cancer metastases may decrease the uptake and, thus, the effects of anti-tumor drugs. Imatinib, a selective inhibitor of PDGF receptors, and anakinra, an interleukin-1 receptor antagonist, respectively, increase drug uptake and/or decrease IFP in preclinical models of carcinoma. Drug-induced decrease in IFP in human metastases has not been objectively shown, but should be reflected by an increase in water-perfusable tissue fraction (PTF) or tumor blood flow (TBF) using [(15)O]water PET/CT and kinetic modelling. Hence, the aim of this study was to assess the effects of imatinib and anakinra on PTF and TBF in colorectal cancer metastases in patients.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Nuclear Medicine
volume
56
issue
8
pages
1144 - 1149
publisher
Society of Nuclear Medicine
external identifiers
  • pmid:26069310
  • wos:000359178300021
  • scopus:84938846080
  • pmid:26069310
ISSN
0161-5505
DOI
10.2967/jnumed.114.151894
language
English
LU publication?
yes
id
6d4ba035-04a0-49da-98d8-b8cc381cdb9a (old id 7486599)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26069310?dopt=Abstract
date added to LUP
2016-04-01 10:52:13
date last changed
2022-02-17 22:07:27
@article{6d4ba035-04a0-49da-98d8-b8cc381cdb9a,
  abstract     = {{High interstitial fluid pressure (IFP) in colorectal cancer metastases may decrease the uptake and, thus, the effects of anti-tumor drugs. Imatinib, a selective inhibitor of PDGF receptors, and anakinra, an interleukin-1 receptor antagonist, respectively, increase drug uptake and/or decrease IFP in preclinical models of carcinoma. Drug-induced decrease in IFP in human metastases has not been objectively shown, but should be reflected by an increase in water-perfusable tissue fraction (PTF) or tumor blood flow (TBF) using [(15)O]water PET/CT and kinetic modelling. Hence, the aim of this study was to assess the effects of imatinib and anakinra on PTF and TBF in colorectal cancer metastases in patients.}},
  author       = {{Lubberink, Mark and Golla, Sandeep S V and Jonasson, My and Rubin, Kristofer and Glimelius, Bengt and Sörensen, Jens and Nygren, Peter}},
  issn         = {{0161-5505}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1144--1149}},
  publisher    = {{Society of Nuclear Medicine}},
  series       = {{Journal of Nuclear Medicine}},
  title        = {{The water-perfusable tissue fraction of colorectal cancer metastases is increased by the selective PDGF-receptor inhibitor imatinib but not the IL-1 receptor antagonist anakinra, a study using serial dynamic 15O-water PET.}},
  url          = {{http://dx.doi.org/10.2967/jnumed.114.151894}},
  doi          = {{10.2967/jnumed.114.151894}},
  volume       = {{56}},
  year         = {{2015}},
}