Harmful somatic amino acid substitutions affect key pathways in cancers.
Niroula, Abhishek LU and Vihinen, Mauno LU
(2015)
In BMC Medical Genomics
8(1).
- Abstract
- Cancer is characterized by the accumulation of large numbers of genetic variations and alterations of multiple biological phenomena. Cancer genomics has largely focused on the identification of such genetic alterations and the genes containing them, known as 'cancer genes'. However, the non-functional somatic variations out-number functional variations and remain as a major challenge. Recurrent somatic variations are thought to be cancer drivers but they are present in only a small fraction of patients.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7840723
- author
- Niroula, Abhishek
LU
and Vihinen, Mauno
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Medical Genomics
- volume
- 8
- issue
- 1
- article number
- 53
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000359979900001
- pmid:26282678
- scopus:84939235946
- pmid:26282678
- ISSN
- 1755-8794
- DOI
- 10.1186/s12920-015-0125-x
- language
- English
- LU publication?
- yes
- id
- 4f763f26-2b92-4175-b9f7-0d81d4ed8a4b (old id 7840723)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26282678?dopt=Abstract
- date added to LUP
- 2016-04-01 13:09:55
- date last changed
- 2022-04-21 20:07:38
@article{4f763f26-2b92-4175-b9f7-0d81d4ed8a4b,
abstract = {{Cancer is characterized by the accumulation of large numbers of genetic variations and alterations of multiple biological phenomena. Cancer genomics has largely focused on the identification of such genetic alterations and the genes containing them, known as 'cancer genes'. However, the non-functional somatic variations out-number functional variations and remain as a major challenge. Recurrent somatic variations are thought to be cancer drivers but they are present in only a small fraction of patients.}},
author = {{Niroula, Abhishek and Vihinen, Mauno}},
issn = {{1755-8794}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Medical Genomics}},
title = {{Harmful somatic amino acid substitutions affect key pathways in cancers.}},
url = {{https://lup.lub.lu.se/search/files/3198736/8603224}},
doi = {{10.1186/s12920-015-0125-x}},
volume = {{8}},
year = {{2015}},
}