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Insights on Genetic and Environmental Factors in Parkinson's Disease from a Regional Swedish Case-Control Cohort

Brolin, Kajsa LU orcid ; Bandres-Ciga, Sara ; Blauwendraat, Cornelis ; Widner, Håkan LU ; Odin, Per LU orcid ; Hansson, Oskar LU orcid ; Puschmann, Andreas LU orcid and Swanberg, Maria LU (2022) In Journal of Parkinson's Disease 12(1). p.153-171
Abstract

BACKGROUND: Risk factors for Parkinson's disease (PD) can be more or less relevant to a population due to population-specific genetic architecture, local lifestyle habits, and environmental exposures. Therefore, it is essential to study PD at a local, regional, and continental scale in order to increase the knowledge on disease etiology.

OBJECTIVE: We aimed to investigate the contribution of genetic and environmental factors to PD in a new Swedish case-control cohort.

METHODS: PD patients (n = 929) and matched population-based controls (n = 935) from the southernmost county in Sweden were included in the cohort. Information on environmental exposures was obtained using questionnaires at inclusion. Genetic analyses included a... (More)

BACKGROUND: Risk factors for Parkinson's disease (PD) can be more or less relevant to a population due to population-specific genetic architecture, local lifestyle habits, and environmental exposures. Therefore, it is essential to study PD at a local, regional, and continental scale in order to increase the knowledge on disease etiology.

OBJECTIVE: We aimed to investigate the contribution of genetic and environmental factors to PD in a new Swedish case-control cohort.

METHODS: PD patients (n = 929) and matched population-based controls (n = 935) from the southernmost county in Sweden were included in the cohort. Information on environmental exposures was obtained using questionnaires at inclusion. Genetic analyses included a genome-wide association study (GWAS), haplotype assessment, and a risk profile analysis using cumulative genetic risk scores.

RESULTS: The cohort is a representative PD case-control cohort (64% men, mean age at diagnosis = 67 years, median Hoehn and Yahr score 2.0), in which previously reported associations between PD and environmental factors, such as tobacco, could be confirmed. We describe the first GWAS of PD solely composed of PD patients from Sweden, and confirm associations to well-established risk alleles in SNCA. In addition, we nominate an unconfirmed and potentially population-specific genome-wide significant association in the PLPP4 locus (rs12771445).

CONCLUSION: This work provides an in-depth description of a new PD case-control cohort from southern Sweden, giving insights into environmental and genetic risk factors for PD in the Swedish population.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Parkinson's Disease
volume
12
issue
1
pages
153 - 171
publisher
IOS Press
external identifiers
  • pmid:34776419
  • scopus:85123814454
ISSN
1877-718X
DOI
10.3233/JPD-212818
language
English
LU publication?
yes
id
7ec05cd4-5203-4d7f-8bfd-40819a747706
date added to LUP
2022-01-25 12:42:03
date last changed
2024-05-02 06:10:42
@article{7ec05cd4-5203-4d7f-8bfd-40819a747706,
  abstract     = {{<p>BACKGROUND: Risk factors for Parkinson's disease (PD) can be more or less relevant to a population due to population-specific genetic architecture, local lifestyle habits, and environmental exposures. Therefore, it is essential to study PD at a local, regional, and continental scale in order to increase the knowledge on disease etiology.</p><p>OBJECTIVE: We aimed to investigate the contribution of genetic and environmental factors to PD in a new Swedish case-control cohort.</p><p>METHODS: PD patients (n = 929) and matched population-based controls (n = 935) from the southernmost county in Sweden were included in the cohort. Information on environmental exposures was obtained using questionnaires at inclusion. Genetic analyses included a genome-wide association study (GWAS), haplotype assessment, and a risk profile analysis using cumulative genetic risk scores.</p><p>RESULTS: The cohort is a representative PD case-control cohort (64% men, mean age at diagnosis = 67 years, median Hoehn and Yahr score 2.0), in which previously reported associations between PD and environmental factors, such as tobacco, could be confirmed. We describe the first GWAS of PD solely composed of PD patients from Sweden, and confirm associations to well-established risk alleles in SNCA. In addition, we nominate an unconfirmed and potentially population-specific genome-wide significant association in the PLPP4 locus (rs12771445).</p><p>CONCLUSION: This work provides an in-depth description of a new PD case-control cohort from southern Sweden, giving insights into environmental and genetic risk factors for PD in the Swedish population.</p>}},
  author       = {{Brolin, Kajsa and Bandres-Ciga, Sara and Blauwendraat, Cornelis and Widner, Håkan and Odin, Per and Hansson, Oskar and Puschmann, Andreas and Swanberg, Maria}},
  issn         = {{1877-718X}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{153--171}},
  publisher    = {{IOS Press}},
  series       = {{Journal of Parkinson's Disease}},
  title        = {{Insights on Genetic and Environmental Factors in Parkinson's Disease from a Regional Swedish Case-Control Cohort}},
  url          = {{http://dx.doi.org/10.3233/JPD-212818}},
  doi          = {{10.3233/JPD-212818}},
  volume       = {{12}},
  year         = {{2022}},
}