Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease
(2020) In Nature Communications 11(1).- Abstract
- In Alzheimer’s diseases (AD), tau pathology is strongly associated with cognitive decline. Preclinical evidence suggests that tau spreads across connected neurons in an activity-dependent manner. Supporting this, cross-sectional AD studies show that tau deposition patterns resemble functional brain networks. However, whether higher functional connectivity is associated with higher rates of tau accumulation is unclear. Here, we combine resting-state fMRI with longitudinal tau-PET in two independent samples including 53 (ADNI) and 41 (BioFINDER) amyloid-biomarker defined AD subjects and 28 (ADNI) vs. 16 (BioFINDER) amyloid-negative healthy controls. In both samples, AD subjects show faster tau accumulation than controls. Second, in AD,... (More)
- In Alzheimer’s diseases (AD), tau pathology is strongly associated with cognitive decline. Preclinical evidence suggests that tau spreads across connected neurons in an activity-dependent manner. Supporting this, cross-sectional AD studies show that tau deposition patterns resemble functional brain networks. However, whether higher functional connectivity is associated with higher rates of tau accumulation is unclear. Here, we combine resting-state fMRI with longitudinal tau-PET in two independent samples including 53 (ADNI) and 41 (BioFINDER) amyloid-biomarker defined AD subjects and 28 (ADNI) vs. 16 (BioFINDER) amyloid-negative healthy controls. In both samples, AD subjects show faster tau accumulation than controls. Second, in AD, higher fMRI-assessed connectivity between 400 regions of interest (ROIs) is associated with correlated tau-PET accumulation in corresponding ROIs. Third, we show that a model including baseline connectivity and tau-PET is associated with future tau-PET accumulation. Together, connectivity is associated with tau spread in AD, supporting the view of transneuronal tau propagation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7f671bc5-4077-46b9-8bce-0c25cb43c1a0
- author
- Franzmeier, Nicolai ; Ossenkoppele, Rik LU ; Hansson, Oskar LU ; Strandberg, Olof LU and Smith, Ruben LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Communications
- volume
- 11
- issue
- 1
- article number
- 347
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85078065413
- ISSN
- 2041-1723
- DOI
- 10.1038/s41467-019-14159-1
- language
- English
- LU publication?
- yes
- id
- 7f671bc5-4077-46b9-8bce-0c25cb43c1a0
- date added to LUP
- 2022-03-29 14:56:44
- date last changed
- 2022-05-15 06:41:35
@article{7f671bc5-4077-46b9-8bce-0c25cb43c1a0, abstract = {{In Alzheimer’s diseases (AD), tau pathology is strongly associated with cognitive decline. Preclinical evidence suggests that tau spreads across connected neurons in an activity-dependent manner. Supporting this, cross-sectional AD studies show that tau deposition patterns resemble functional brain networks. However, whether higher functional connectivity is associated with higher rates of tau accumulation is unclear. Here, we combine resting-state fMRI with longitudinal tau-PET in two independent samples including 53 (ADNI) and 41 (BioFINDER) amyloid-biomarker defined AD subjects and 28 (ADNI) vs. 16 (BioFINDER) amyloid-negative healthy controls. In both samples, AD subjects show faster tau accumulation than controls. Second, in AD, higher fMRI-assessed connectivity between 400 regions of interest (ROIs) is associated with correlated tau-PET accumulation in corresponding ROIs. Third, we show that a model including baseline connectivity and tau-PET is associated with future tau-PET accumulation. Together, connectivity is associated with tau spread in AD, supporting the view of transneuronal tau propagation.}}, author = {{Franzmeier, Nicolai and Ossenkoppele, Rik and Hansson, Oskar and Strandberg, Olof and Smith, Ruben}}, issn = {{2041-1723}}, language = {{eng}}, number = {{1}}, publisher = {{Nature Publishing Group}}, series = {{Nature Communications}}, title = {{Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease}}, url = {{http://dx.doi.org/10.1038/s41467-019-14159-1}}, doi = {{10.1038/s41467-019-14159-1}}, volume = {{11}}, year = {{2020}}, }