Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors
(2018) In Nature Immunology 19. p.302-314- Abstract
- The quantification and characterization of circulating immune cells provide key indicators of human health and disease. To identify the relative effects of environmental and genetic factors on variation in the parameters of innate and adaptive immune cells in homeostatic conditions, we combined standardized flow cytometry of blood leukocytes and genome-wide DNA genotyping of 1,000 healthy, unrelated people of Western European ancestry. We found that smoking, together with age, sex and latent infection with cytomegalovirus, were the main non-genetic factors that affected variation in parameters of human immune cells. Genome-wide association studies of 166 immunophenotypes identified 15 loci that showed enrichment for disease-associated... (More)
- The quantification and characterization of circulating immune cells provide key indicators of human health and disease. To identify the relative effects of environmental and genetic factors on variation in the parameters of innate and adaptive immune cells in homeostatic conditions, we combined standardized flow cytometry of blood leukocytes and genome-wide DNA genotyping of 1,000 healthy, unrelated people of Western European ancestry. We found that smoking, together with age, sex and latent infection with cytomegalovirus, were the main non-genetic factors that affected variation in parameters of human immune cells. Genome-wide association studies of 166 immunophenotypes identified 15 loci that showed enrichment for disease-associated variants. Finally, we demonstrated that the parameters of innate cells were more strongly controlled by genetic variation than were those of adaptive cells, which were driven by mainly environmental exposure. Our data establish a resource that will generate new hypotheses in immunology and highlight the role of innate immunity in susceptibility to common autoimmune diseases. (Less)
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https://lup.lub.lu.se/record/856ab6b2-b1f1-40a6-aa60-1f2d51d455cf
- author
- author collaboration
- organization
- publishing date
- 2018-02-23
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Immunology
- volume
- 19
- pages
- 302 - 314
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85042410142
- pmid:29476184
- ISSN
- 1529-2908
- DOI
- 10.1038/s41590-018-0049-7
- language
- English
- LU publication?
- yes
- id
- 856ab6b2-b1f1-40a6-aa60-1f2d51d455cf
- date added to LUP
- 2018-02-26 14:41:38
- date last changed
- 2022-08-23 11:05:02
@article{856ab6b2-b1f1-40a6-aa60-1f2d51d455cf, abstract = {{The quantification and characterization of circulating immune cells provide key indicators of human health and disease. To identify the relative effects of environmental and genetic factors on variation in the parameters of innate and adaptive immune cells in homeostatic conditions, we combined standardized flow cytometry of blood leukocytes and genome-wide DNA genotyping of 1,000 healthy, unrelated people of Western European ancestry. We found that smoking, together with age, sex and latent infection with cytomegalovirus, were the main non-genetic factors that affected variation in parameters of human immune cells. Genome-wide association studies of 166 immunophenotypes identified 15 loci that showed enrichment for disease-associated variants. Finally, we demonstrated that the parameters of innate cells were more strongly controlled by genetic variation than were those of adaptive cells, which were driven by mainly environmental exposure. Our data establish a resource that will generate new hypotheses in immunology and highlight the role of innate immunity in susceptibility to common autoimmune diseases.}}, author = {{Patin, Etienne and Hasan, Milena and Bergstedt, Jacob and Rouilly, Vincent and Libri, Valentina and Urrutia, Alejandra and Alanio, Cécile and Scepanovic, Petar and Hammer, Christian and Jönsson, Friederike and Beitz, Benoît and Quach, Helene and Lim, Yoong Wearn and Hunkapiller, Julie and Zepeda, Magge and Green, Cherie and Piasecka, Barbara and Leloup, Claire and Rogge, Lars and Huetz, François and Peguillet, Isabelle and Lantz, Olivier and Fontes, Magnus and Santo, James P. and Thomas, Stéphanie and Fellay, Jacques and Duffy, Darragh and Quintana-Murci, Lluis and Albert, Matthew L}}, issn = {{1529-2908}}, language = {{eng}}, month = {{02}}, pages = {{302--314}}, publisher = {{Nature Publishing Group}}, series = {{Nature Immunology}}, title = {{Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors}}, url = {{http://dx.doi.org/10.1038/s41590-018-0049-7}}, doi = {{10.1038/s41590-018-0049-7}}, volume = {{19}}, year = {{2018}}, }