Discovery of epi-enprioline as a novel drug for the treatment of vincristine resistant neuroblastoma
(2020) In International Journal of Molecular Sciences 21(18).- Abstract
Neuroblastoma is a childhood solid tumour originating from undifferentiated neural progenitor cells of the sympathetic nervous system. Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. In the present study, we aimed to identify novel drugs that can inhibit the growth and survival of chemoresistant neuroblastoma. High-throughput screening identified a small molecule, epi-enprioline that was able to induce apoptosis of vincristine-resistant neuroblastoma cells via the mitochondrial apoptotic pathway. Epi-enprioline reduced tumour growth in multiple preclinical models, including an orthotopic neuroblastoma patient-derived xenograft model in vivo. In summary, our data suggest that epi-enprioline can be... (More)
Neuroblastoma is a childhood solid tumour originating from undifferentiated neural progenitor cells of the sympathetic nervous system. Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. In the present study, we aimed to identify novel drugs that can inhibit the growth and survival of chemoresistant neuroblastoma. High-throughput screening identified a small molecule, epi-enprioline that was able to induce apoptosis of vincristine-resistant neuroblastoma cells via the mitochondrial apoptotic pathway. Epi-enprioline reduced tumour growth in multiple preclinical models, including an orthotopic neuroblastoma patient-derived xenograft model in vivo. In summary, our data suggest that epi-enprioline can be considered as a lead compound for the treatment of vincristine-resistant neuroblastoma uncovering a novel strategy, which can be further explored as a treatment for drug-resistant neuroblastoma.
(Less)
- author
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Apoptosis, Chemoresistance, Epi-enprioline, Neuroblastoma, Vincristine
- in
- International Journal of Molecular Sciences
- volume
- 21
- issue
- 18
- article number
- 6577
- pages
- 15 pages
- publisher
- MDPI AG
- external identifiers
-
- scopus:85090630185
- pmid:32911859
- ISSN
- 1661-6596
- DOI
- 10.3390/ijms21186577
- language
- English
- LU publication?
- yes
- id
- 857cc6be-827f-4c12-86d0-bfdfcc4d9bdc
- date added to LUP
- 2020-09-29 15:47:55
- date last changed
- 2024-04-03 14:58:09
@article{857cc6be-827f-4c12-86d0-bfdfcc4d9bdc, abstract = {{<p>Neuroblastoma is a childhood solid tumour originating from undifferentiated neural progenitor cells of the sympathetic nervous system. Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. In the present study, we aimed to identify novel drugs that can inhibit the growth and survival of chemoresistant neuroblastoma. High-throughput screening identified a small molecule, epi-enprioline that was able to induce apoptosis of vincristine-resistant neuroblastoma cells via the mitochondrial apoptotic pathway. Epi-enprioline reduced tumour growth in multiple preclinical models, including an orthotopic neuroblastoma patient-derived xenograft model in vivo. In summary, our data suggest that epi-enprioline can be considered as a lead compound for the treatment of vincristine-resistant neuroblastoma uncovering a novel strategy, which can be further explored as a treatment for drug-resistant neuroblastoma.</p>}}, author = {{Sime, Wondossen and Jemaà, Mohamed and Abassi, Yasmin and Lasorsa, Vito Alessandro and Køhler, Julie Bonne and Hansson, Karin and Bexell, Daniel and Michaelis, Martin and Cinatl, Jindrich and Strand, Daniel and Capasso, Mario and Massoumi, Ramin}}, issn = {{1661-6596}}, keywords = {{Apoptosis; Chemoresistance; Epi-enprioline; Neuroblastoma; Vincristine}}, language = {{eng}}, number = {{18}}, publisher = {{MDPI AG}}, series = {{International Journal of Molecular Sciences}}, title = {{Discovery of epi-enprioline as a novel drug for the treatment of vincristine resistant neuroblastoma}}, url = {{http://dx.doi.org/10.3390/ijms21186577}}, doi = {{10.3390/ijms21186577}}, volume = {{21}}, year = {{2020}}, }