Cold intolerance and neuropathic pain after peripheral nerve injury in upper extremity
Magistroni, Ernesta ; Parodi, Giulia ; Fop, Fabrizio ; Battiston, Bruno and Dahlin, Lars B. LU
(2020)
In Journal of the Peripheral Nervous System
25(2).
p.184-190
- Abstract
Cold intolerance and pain can be a substantial problem in patients with peripheral nerve injury. We aimed at investigating the relationships among sensory recovery, cold intolerance, and neuropathic pain in patients affected by upper limb peripheral nerve injury (Sunderland type V) treated with microsurgical repair, followed by early sensory re-education. In a cross-sectional clinical study, 100 patients (male/female 81/19; age 40.5 ± 14.8 years and follow-up 17 ± 5 months, mean ± SD), with microsurgical nerve repair and reconstruction in the upper extremity and subsequent early sensory re-education, were evaluated, using Cold Intolerance Symptoms Severity questionnaire-Italian version (CISS-it, cut-off pathology >30/100 points),... (More)
Cold intolerance and pain can be a substantial problem in patients with peripheral nerve injury. We aimed at investigating the relationships among sensory recovery, cold intolerance, and neuropathic pain in patients affected by upper limb peripheral nerve injury (Sunderland type V) treated with microsurgical repair, followed by early sensory re-education. In a cross-sectional clinical study, 100 patients (male/female 81/19; age 40.5 ± 14.8 years and follow-up 17 ± 5 months, mean ± SD), with microsurgical nerve repair and reconstruction in the upper extremity and subsequent early sensory re-education, were evaluated, using Cold Intolerance Symptoms Severity questionnaire-Italian version (CISS-it, cut-off pathology >30/100 points), CISS questionnaire-12 item version (CISS-12, 0-46 points-grouping: healthy that means no cold intolerance [0-14], mild [15-24], moderate [25-34], severe [35-42], very severe [43-46] cold intolerance), probability of neuropathic pain (DouleurNeuropathique-4; [DN4] 4/10), deep and superficial sensibility, tactile threshold (monofilaments), and two-point discrimination (cutoff S2; Medical Research Council scale for sensory function; [MRC-scale]). A high CISS score is associated with possible neuropathic pain (DN4 ≥ 4). Both a low CISS-it score (ie, < 30) and DN4 < 4 is associated with good sensory recovery (MRC ≥ 2). In conclusion patients affected by upper limb peripheral nerve injuries with higher CISS scores more often suffer from cold intolerance and neuropathic pain, and the better their sensory recovery is, the less likely they are to suffer from cold intolerance and neuropathic pain.
(Less)
- author
- Magistroni, Ernesta
; Parodi, Giulia
; Fop, Fabrizio
; Battiston, Bruno
and Dahlin, Lars B.
LU
- organization
- publishing date
- 2020-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cold intolerance, nerve repair, neuropathic pain, peripheral nerve injury, sensory re-education
- in
- Journal of the Peripheral Nervous System
- volume
- 25
- issue
- 2
- pages
- 7 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:32297385
- scopus:85083962357
- ISSN
- 1085-9489
- DOI
- 10.1111/jns.12376
- language
- English
- LU publication?
- yes
- id
- 87601b0a-4bbe-4446-a216-20ba665d2759
- date added to LUP
- 2020-05-28 12:03:40
- date last changed
- 2024-06-26 15:52:43
@article{87601b0a-4bbe-4446-a216-20ba665d2759,
abstract = {{<p>Cold intolerance and pain can be a substantial problem in patients with peripheral nerve injury. We aimed at investigating the relationships among sensory recovery, cold intolerance, and neuropathic pain in patients affected by upper limb peripheral nerve injury (Sunderland type V) treated with microsurgical repair, followed by early sensory re-education. In a cross-sectional clinical study, 100 patients (male/female 81/19; age 40.5 ± 14.8 years and follow-up 17 ± 5 months, mean ± SD), with microsurgical nerve repair and reconstruction in the upper extremity and subsequent early sensory re-education, were evaluated, using Cold Intolerance Symptoms Severity questionnaire-Italian version (CISS-it, cut-off pathology >30/100 points), CISS questionnaire-12 item version (CISS-12, 0-46 points-grouping: healthy that means no cold intolerance [0-14], mild [15-24], moderate [25-34], severe [35-42], very severe [43-46] cold intolerance), probability of neuropathic pain (DouleurNeuropathique-4; [DN4] 4/10), deep and superficial sensibility, tactile threshold (monofilaments), and two-point discrimination (cutoff S2; Medical Research Council scale for sensory function; [MRC-scale]). A high CISS score is associated with possible neuropathic pain (DN4 ≥ 4). Both a low CISS-it score (ie, < 30) and DN4 < 4 is associated with good sensory recovery (MRC ≥ 2). In conclusion patients affected by upper limb peripheral nerve injuries with higher CISS scores more often suffer from cold intolerance and neuropathic pain, and the better their sensory recovery is, the less likely they are to suffer from cold intolerance and neuropathic pain.</p>}},
author = {{Magistroni, Ernesta and Parodi, Giulia and Fop, Fabrizio and Battiston, Bruno and Dahlin, Lars B.}},
issn = {{1085-9489}},
keywords = {{cold intolerance; nerve repair; neuropathic pain; peripheral nerve injury; sensory re-education}},
language = {{eng}},
number = {{2}},
pages = {{184--190}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of the Peripheral Nervous System}},
title = {{Cold intolerance and neuropathic pain after peripheral nerve injury in upper extremity}},
url = {{http://dx.doi.org/10.1111/jns.12376}},
doi = {{10.1111/jns.12376}},
volume = {{25}},
year = {{2020}},
}