Renal cell carcinoma recurrences and metastases in primary non-metastatic patients: a population-based study.
(2016) In World Journal of Urology- Abstract
- To present the occurrence of metastases and local recurrences in primary non-metastatic patients with renal cell carcinoma (RCC) in a contemporary Swedish population-based cohort. Between 2005 and 2009, a total of 4527 patients were included in the prospective National Swedish Kidney Cancer Register accounting for nearly all RCC patients in Sweden. Among M0 patients, 472 (13 %) had no follow-up data registered within 5-year follow-up time and were excluded from the analysis.
In total, 939 (21 %) had distant metastases at presentation with a decrease from 23 to 18 % during the inclusion period. Of 3107 patients with follow-up data and with M0 disease, 623 (20 %) were diagnosed with a tumor recurrence during 5-year follow-up. Mean... (More) - To present the occurrence of metastases and local recurrences in primary non-metastatic patients with renal cell carcinoma (RCC) in a contemporary Swedish population-based cohort. Between 2005 and 2009, a total of 4527 patients were included in the prospective National Swedish Kidney Cancer Register accounting for nearly all RCC patients in Sweden. Among M0 patients, 472 (13 %) had no follow-up data registered within 5-year follow-up time and were excluded from the analysis.
In total, 939 (21 %) had distant metastases at presentation with a decrease from 23 to 18 % during the inclusion period. Of 3107 patients with follow-up data and with M0 disease, 623 (20 %) were diagnosed with a tumor recurrence during 5-year follow-up. Mean time to recurrence was 24 months (SD ± 20 months). Among these, 570 patients (92 %) were at primary diagnosis treated with radical nephrectomy, 23 patients (3.7 %) with partial nephrectomy and 12 patients (1.9 %) with minimally invasive treatments. The most frequent sites of metastases were lung (54 %), lymph nodes (22 %) and bone (20 %). The treatment of recurrence was in 50 % systemic treatments, while metastasectomy was performed in 17 % of the patients, out of which 68 % were with a curative intention.
In this population-based study, 21 % of the patients had metastatic disease at presentation, with a decreasing trend over the study period. During 5-year follow-up, 20 % of the primary non-metastatic patients had recurrent disease. Of the patients with recurrence, half were given systemic oncological treatment and 17 % underwent metastasectomy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8829253
- author
- Dabestani, Saeed LU ; Thorstenson, Andreas ; Lindblad, Per ; Harmenberg, Ulrika ; Ljungberg, Börje and Lundstam, Sven
- publishing date
- 2016-02-05
- type
- Contribution to journal
- publication status
- published
- subject
- in
- World Journal of Urology
- publisher
- Springer
- external identifiers
-
- pmid:26847337
- scopus:84957538219
- pmid:26847337
- wos:000381101100006
- ISSN
- 1433-8726
- DOI
- 10.1007/s00345-016-1773-y
- language
- English
- LU publication?
- no
- id
- f7b59c06-7bb1-4cd3-8e99-932b1fc70511 (old id 8829253)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26847337?dopt=Abstract
- date added to LUP
- 2016-04-01 15:05:02
- date last changed
- 2022-04-06 22:08:29
@article{f7b59c06-7bb1-4cd3-8e99-932b1fc70511,
abstract = {{To present the occurrence of metastases and local recurrences in primary non-metastatic patients with renal cell carcinoma (RCC) in a contemporary Swedish population-based cohort. Between 2005 and 2009, a total of 4527 patients were included in the prospective National Swedish Kidney Cancer Register accounting for nearly all RCC patients in Sweden. Among M0 patients, 472 (13 %) had no follow-up data registered within 5-year follow-up time and were excluded from the analysis. <br/><br>
In total, 939 (21 %) had distant metastases at presentation with a decrease from 23 to 18 % during the inclusion period. Of 3107 patients with follow-up data and with M0 disease, 623 (20 %) were diagnosed with a tumor recurrence during 5-year follow-up. Mean time to recurrence was 24 months (SD ± 20 months). Among these, 570 patients (92 %) were at primary diagnosis treated with radical nephrectomy, 23 patients (3.7 %) with partial nephrectomy and 12 patients (1.9 %) with minimally invasive treatments. The most frequent sites of metastases were lung (54 %), lymph nodes (22 %) and bone (20 %). The treatment of recurrence was in 50 % systemic treatments, while metastasectomy was performed in 17 % of the patients, out of which 68 % were with a curative intention.<br/><br>
In this population-based study, 21 % of the patients had metastatic disease at presentation, with a decreasing trend over the study period. During 5-year follow-up, 20 % of the primary non-metastatic patients had recurrent disease. Of the patients with recurrence, half were given systemic oncological treatment and 17 % underwent metastasectomy.}},
author = {{Dabestani, Saeed and Thorstenson, Andreas and Lindblad, Per and Harmenberg, Ulrika and Ljungberg, Börje and Lundstam, Sven}},
issn = {{1433-8726}},
language = {{eng}},
month = {{02}},
publisher = {{Springer}},
series = {{World Journal of Urology}},
title = {{Renal cell carcinoma recurrences and metastases in primary non-metastatic patients: a population-based study.}},
url = {{http://dx.doi.org/10.1007/s00345-016-1773-y}},
doi = {{10.1007/s00345-016-1773-y}},
year = {{2016}},
}