Community study of the relative impact of HIV-1 and HIV-2 on intrathoracic tuberculosis
(2002) In AIDS 16(7). p.1059-1066- Abstract
- Background: HIV-1 infection is associated with an increased incidence of and mortality from tuberculosis. Few community studies have examined the effect of HIV-2 on tuberculosis. Methods: We investigated the association between HIV-1, HIV-2 and active tuberculosis in four districts (population 42 709) in Bissau, capital of Guinea-Bissau, with the highest known seroprevalence of HIV-2 infection in the world. From May 1996 to June 1998, tuberculosis surveillance and active case finding among contacts was conducted. Patients were HIV-tested, given specific tuberculosis treatment for 8 months and followed regarding mortality. Simultaneously, an HIV sero-survey was performed in a random sample of 1748 permanent residents. Results: During a... (More)
- Background: HIV-1 infection is associated with an increased incidence of and mortality from tuberculosis. Few community studies have examined the effect of HIV-2 on tuberculosis. Methods: We investigated the association between HIV-1, HIV-2 and active tuberculosis in four districts (population 42 709) in Bissau, capital of Guinea-Bissau, with the highest known seroprevalence of HIV-2 infection in the world. From May 1996 to June 1998, tuberculosis surveillance and active case finding among contacts was conducted. Patients were HIV-tested, given specific tuberculosis treatment for 8 months and followed regarding mortality. Simultaneously, an HIV sero-survey was performed in a random sample of 1748 permanent residents. Results: During a 25-month period, 366 tuberculosis cases were identified. After excluding cases among visitors to the area, and adjusting for age, the incidence of tuberculosis was 18.3 times higher (95% CI 12.9-26.0) among HIV-1-positive individuals, 13.7 times higher (9.0-20.7) among dually infected (HIV-1 and HIV-2), and 3.0 times higher (2.1-4.3) among HIV-2-infected compared with HIV-negative individuals. HIV-1 and dually infected tuberculosis patients had a higher mortality rate than HIV-negative tuberculosis patients [mortality ratio (MR) 2.68; CI 1.11 -6.48 and 2.89; CI 1.13-7.39, respectively]. The survival of HIV-2-positive tuberculosis patients was similar to that of HIV-negative tuberculosis patients (MR 1.19; CI 0.46-3.06). Conclusion: The presence of HIV-2 infection increases the incidence of tuberculosis compared with that in non-HIV-infected individuals, but does not affect tuberculosis-related mortality in the short term. In contrast, the presence of HIV-1 infection, alone or with HIV-2, has a several-fold greater impact on both the incidence of and mortality from tuberculosis. (C) 2002 Lippincott Williams Wilkins. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/893414
- author
- Seng, R ; Gustafson, Per LU ; Gomes, VF ; Vieira, CS ; Rabna, P ; Larsen, O ; Larouze, B ; Norberg, R ; Lisse, IM and Samb, B
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- co-infection, HIV-1, HIV-2, tuberculosis, mortality, incidence, Africa, community
- in
- AIDS
- volume
- 16
- issue
- 7
- pages
- 1059 - 1066
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000175517900013
- pmid:11953473
- scopus:0037013098
- ISSN
- 1473-5571
- language
- English
- LU publication?
- yes
- id
- b355bc7a-19bf-4389-a62d-e674690bd091 (old id 893414)
- alternative location
- http://www.aidsonline.com/pt/re/aids/fulltext.00002030-200205030-00013.htm
- date added to LUP
- 2016-04-01 12:08:09
- date last changed
- 2022-03-28 20:45:38
@article{b355bc7a-19bf-4389-a62d-e674690bd091,
abstract = {{Background: HIV-1 infection is associated with an increased incidence of and mortality from tuberculosis. Few community studies have examined the effect of HIV-2 on tuberculosis. Methods: We investigated the association between HIV-1, HIV-2 and active tuberculosis in four districts (population 42 709) in Bissau, capital of Guinea-Bissau, with the highest known seroprevalence of HIV-2 infection in the world. From May 1996 to June 1998, tuberculosis surveillance and active case finding among contacts was conducted. Patients were HIV-tested, given specific tuberculosis treatment for 8 months and followed regarding mortality. Simultaneously, an HIV sero-survey was performed in a random sample of 1748 permanent residents. Results: During a 25-month period, 366 tuberculosis cases were identified. After excluding cases among visitors to the area, and adjusting for age, the incidence of tuberculosis was 18.3 times higher (95% CI 12.9-26.0) among HIV-1-positive individuals, 13.7 times higher (9.0-20.7) among dually infected (HIV-1 and HIV-2), and 3.0 times higher (2.1-4.3) among HIV-2-infected compared with HIV-negative individuals. HIV-1 and dually infected tuberculosis patients had a higher mortality rate than HIV-negative tuberculosis patients [mortality ratio (MR) 2.68; CI 1.11 -6.48 and 2.89; CI 1.13-7.39, respectively]. The survival of HIV-2-positive tuberculosis patients was similar to that of HIV-negative tuberculosis patients (MR 1.19; CI 0.46-3.06). Conclusion: The presence of HIV-2 infection increases the incidence of tuberculosis compared with that in non-HIV-infected individuals, but does not affect tuberculosis-related mortality in the short term. In contrast, the presence of HIV-1 infection, alone or with HIV-2, has a several-fold greater impact on both the incidence of and mortality from tuberculosis. (C) 2002 Lippincott Williams Wilkins.}},
author = {{Seng, R and Gustafson, Per and Gomes, VF and Vieira, CS and Rabna, P and Larsen, O and Larouze, B and Norberg, R and Lisse, IM and Samb, B}},
issn = {{1473-5571}},
keywords = {{co-infection; HIV-1; HIV-2; tuberculosis; mortality; incidence; Africa; community}},
language = {{eng}},
number = {{7}},
pages = {{1059--1066}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{AIDS}},
title = {{Community study of the relative impact of HIV-1 and HIV-2 on intrathoracic tuberculosis}},
url = {{http://www.aidsonline.com/pt/re/aids/fulltext.00002030-200205030-00013.htm}},
volume = {{16}},
year = {{2002}},
}