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The order of completing MDP and D12 does not affect the breathlessness responses: A randomised controlled trial

Wemar, Isabelle ; Sandberg, Jacob LU orcid ; Olsson, Max LU orcid ; Sundh, Josefin and Ekström, Magnus LU orcid (2025) In Chronic Respiratory Disease 22. p.1-6
Abstract
Background
Breathlessness is a common and distressing symptom across a wide range of medical conditions. Different aspects (dimensions) of breathlessness can be assessed using the Multidimensional Dyspnoea Profile (MDP) and Dyspnoea-12 (D12) questionnaires. We aimed to examine whether the order of completing MDP and D12 affects the breathlessness responses in people with cardiorespiratory disease.
Methods
This was a randomised controlled trial embedded within a longitudinal clinical study. Outpatients with cardiorespiratory disease were randomly assigned to either first complete the MDP or the D12. Primary outcome was mean difference in D12 total score between groups, secondary outcome was mean difference in D12 and MDP... (More)
Background
Breathlessness is a common and distressing symptom across a wide range of medical conditions. Different aspects (dimensions) of breathlessness can be assessed using the Multidimensional Dyspnoea Profile (MDP) and Dyspnoea-12 (D12) questionnaires. We aimed to examine whether the order of completing MDP and D12 affects the breathlessness responses in people with cardiorespiratory disease.
Methods
This was a randomised controlled trial embedded within a longitudinal clinical study. Outpatients with cardiorespiratory disease were randomly assigned to either first complete the MDP or the D12. Primary outcome was mean difference in D12 total score between groups, secondary outcome was mean difference in D12 and MDP subdomain scores. Both outcomes were compared to the minimal clinically important difference (MCID) for each scale.
Results
All 182 participants from the longitudinal study were included. 93 were randomized to complete MDP first and 89 to D12 first. Characteristics such as age, sex, main cause of breathlessness and smoking status were similar between groups. The mean difference for D12 total score (MCID = 2.8) was −1.5 (−4.2 to 1.3, p = 0.26) between groups. Mean differences between groups in subdomain scores were also below the corresponding MCID.
Conclusion
The order of completion of MDP and D12 did not impact the scores significantly, but the study lacked power to find smaller yet clinically significant differences. The study supports that the most practical order of completing the instruments can be used in future research and in clinical settings. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Chronic Respiratory Disease
volume
22
pages
1 - 6
publisher
SAGE Publications
external identifiers
  • pmid:41166646
  • scopus:105020426257
ISSN
1479-9723
DOI
10.1177/14799731251393985
language
English
LU publication?
yes
id
89796cfc-1f4c-4a86-aace-c4a720d5bc54
alternative location
https://journals.sagepub.com/doi/10.1177/14799731251393985
date added to LUP
2025-12-04 10:14:50
date last changed
2025-12-05 04:01:17
@article{89796cfc-1f4c-4a86-aace-c4a720d5bc54,
  abstract     = {{Background<br/>Breathlessness is a common and distressing symptom across a wide range of medical conditions. Different aspects (dimensions) of breathlessness can be assessed using the Multidimensional Dyspnoea Profile (MDP) and Dyspnoea-12 (D12) questionnaires. We aimed to examine whether the order of completing MDP and D12 affects the breathlessness responses in people with cardiorespiratory disease.<br/>Methods<br/>This was a randomised controlled trial embedded within a longitudinal clinical study. Outpatients with cardiorespiratory disease were randomly assigned to either first complete the MDP or the D12. Primary outcome was mean difference in D12 total score between groups, secondary outcome was mean difference in D12 and MDP subdomain scores. Both outcomes were compared to the minimal clinically important difference (MCID) for each scale.<br/>Results<br/>All 182 participants from the longitudinal study were included. 93 were randomized to complete MDP first and 89 to D12 first. Characteristics such as age, sex, main cause of breathlessness and smoking status were similar between groups. The mean difference for D12 total score (MCID = 2.8) was −1.5 (−4.2 to 1.3, p = 0.26) between groups. Mean differences between groups in subdomain scores were also below the corresponding MCID.<br/>Conclusion<br/>The order of completion of MDP and D12 did not impact the scores significantly, but the study lacked power to find smaller yet clinically significant differences. The study supports that the most practical order of completing the instruments can be used in future research and in clinical settings.}},
  author       = {{Wemar, Isabelle and Sandberg, Jacob and Olsson, Max and Sundh, Josefin and Ekström, Magnus}},
  issn         = {{1479-9723}},
  language     = {{eng}},
  month        = {{10}},
  pages        = {{1--6}},
  publisher    = {{SAGE Publications}},
  series       = {{Chronic Respiratory Disease}},
  title        = {{The order of completing MDP and D12 does not affect the breathlessness responses: A randomised controlled trial}},
  url          = {{http://dx.doi.org/10.1177/14799731251393985}},
  doi          = {{10.1177/14799731251393985}},
  volume       = {{22}},
  year         = {{2025}},
}