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Plasma Galectin-4 Levels Are Increased after Stroke in Mice and Humans

Jujic, Amra LU orcid ; Vieira, João LU ; Matuskova, Hana LU ; Nilsson, Peter M LU ; Lindblad, Ulf ; Olsen, Michael H. ; Duarte, Joao LU orcid ; Meissner, Anja LU orcid and Magnusson, Martin LU orcid (2023) In International Journal of Molecular Sciences 24(12).
Abstract
Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with an increased risk of coronary artery disease. To date, data regarding possible associations between plasma Gal-4 and stroke are lacking. Using linear and logistic regression analyses, we tested Gal-4 association with prevalent stroke in a population-based cohort. Additionally, in mice fed a high-fat diet (HFD), we investigated whether plasma Gal-4 increases in response to ischemic stroke. Plasma Gal-4 was higher in subjects with prevalent ischemic stroke, and was associated with prevalent ischemic stroke (odds ratio 1.52; 95% confidence interval 1.01–2.30; p = 0.048) adjusted for age, sex, and covariates of... (More)
Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with an increased risk of coronary artery disease. To date, data regarding possible associations between plasma Gal-4 and stroke are lacking. Using linear and logistic regression analyses, we tested Gal-4 association with prevalent stroke in a population-based cohort. Additionally, in mice fed a high-fat diet (HFD), we investigated whether plasma Gal-4 increases in response to ischemic stroke. Plasma Gal-4 was higher in subjects with prevalent ischemic stroke, and was associated with prevalent ischemic stroke (odds ratio 1.52; 95% confidence interval 1.01–2.30; p = 0.048) adjusted for age, sex, and covariates of cardiometabolic health. Plasma Gal-4 increased after experimental stroke in both controls and HFD-fed mice. HFD exposure was devoid of impact on Gal-4 levels. This study demonstrates higher plasma Gal-4 levels in both experimental stroke and in humans that experienced ischemic stroke. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Molecular Sciences
volume
24
issue
12
article number
10064
publisher
MDPI AG
external identifiers
  • pmid:37373212
  • scopus:85163928982
ISSN
1422-0067
DOI
10.3390/ijms241210064
language
English
LU publication?
yes
id
8a6f58d8-3901-463b-95aa-dccbab7df5b8
date added to LUP
2023-06-13 12:07:20
date last changed
2025-10-14 12:12:48
@article{8a6f58d8-3901-463b-95aa-dccbab7df5b8,
  abstract     = {{Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with an increased risk of coronary artery disease. To date, data regarding possible associations between plasma Gal-4 and stroke are lacking. Using linear and logistic regression analyses, we tested Gal-4 association with prevalent stroke in a population-based cohort. Additionally, in mice fed a high-fat diet (HFD), we investigated whether plasma Gal-4 increases in response to ischemic stroke. Plasma Gal-4 was higher in subjects with prevalent ischemic stroke, and was associated with prevalent ischemic stroke (odds ratio 1.52; 95% confidence interval 1.01–2.30; p = 0.048) adjusted for age, sex, and covariates of cardiometabolic health. Plasma Gal-4 increased after experimental stroke in both controls and HFD-fed mice. HFD exposure was devoid of impact on Gal-4 levels. This study demonstrates higher plasma Gal-4 levels in both experimental stroke and in humans that experienced ischemic stroke.}},
  author       = {{Jujic, Amra and Vieira, João and Matuskova, Hana and Nilsson, Peter M and Lindblad, Ulf and Olsen, Michael H. and Duarte, Joao and Meissner, Anja and Magnusson, Martin}},
  issn         = {{1422-0067}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{12}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Molecular Sciences}},
  title        = {{Plasma Galectin-4 Levels Are Increased after Stroke in Mice and Humans}},
  url          = {{http://dx.doi.org/10.3390/ijms241210064}},
  doi          = {{10.3390/ijms241210064}},
  volume       = {{24}},
  year         = {{2023}},
}