Plasma Galectin-4 Levels Are Increased after Stroke in Mice and Humans
Jujic, Amra LU ; Vieira, João LU ; Matuskova, Hana LU ; Nilsson, Peter M LU ; Lindblad, Ulf ; Olsen, Michael H. ; Duarte, Joao LU
; Meissner, Anja
LU
and Magnusson, Martin
LU
(2023)
In International Journal of Molecular Sciences
24(12).
- Abstract
- Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with an increased risk of coronary artery disease. To date, data regarding possible associations between plasma Gal-4 and stroke are lacking. Using linear and logistic regression analyses, we tested Gal-4 association with prevalent stroke in a population-based cohort. Additionally, in mice fed a high-fat diet (HFD), we investigated whether plasma Gal-4 increases in response to ischemic stroke. Plasma Gal-4 was higher in subjects with prevalent ischemic stroke, and was associated with prevalent ischemic stroke (odds ratio 1.52; 95% confidence interval 1.01–2.30; p = 0.048) adjusted for age, sex, and covariates of... (More)
- Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with an increased risk of coronary artery disease. To date, data regarding possible associations between plasma Gal-4 and stroke are lacking. Using linear and logistic regression analyses, we tested Gal-4 association with prevalent stroke in a population-based cohort. Additionally, in mice fed a high-fat diet (HFD), we investigated whether plasma Gal-4 increases in response to ischemic stroke. Plasma Gal-4 was higher in subjects with prevalent ischemic stroke, and was associated with prevalent ischemic stroke (odds ratio 1.52; 95% confidence interval 1.01–2.30; p = 0.048) adjusted for age, sex, and covariates of cardiometabolic health. Plasma Gal-4 increased after experimental stroke in both controls and HFD-fed mice. HFD exposure was devoid of impact on Gal-4 levels. This study demonstrates higher plasma Gal-4 levels in both experimental stroke and in humans that experienced ischemic stroke. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8a6f58d8-3901-463b-95aa-dccbab7df5b8
- author
- Jujic, Amra
LU
; Vieira, João
LU
; Matuskova, Hana
LU
; Nilsson, Peter M
LU
; Lindblad, Ulf
; Olsen, Michael H.
; Duarte, Joao
LU
; Meissner, Anja
LU
and Magnusson, Martin
LU
- organization
-
- EXODIAB: Excellence of Diabetes Research in Sweden
- Cardiovascular Research - Hypertension (research group)
- WCMM-Wallenberg Centre for Molecular Medicine
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- Diabetes and Brain Function (research group)
- Department of Experimental Medical Science
- Internal Medicine - Epidemiology (research group)
- EpiHealth: Epidemiology for Health
- LU Profile Area: Proactive Ageing
- Vascular Biology (research group)
- publishing date
- 2023-05-13
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Molecular Sciences
- volume
- 24
- issue
- 12
- article number
- 10064
- publisher
- MDPI AG
- external identifiers
-
- pmid:37373212
- scopus:85163928982
- ISSN
- 1422-0067
- DOI
- 10.3390/ijms241210064
- language
- English
- LU publication?
- yes
- id
- 8a6f58d8-3901-463b-95aa-dccbab7df5b8
- date added to LUP
- 2023-06-13 12:07:20
- date last changed
- 2024-08-10 11:51:57
@article{8a6f58d8-3901-463b-95aa-dccbab7df5b8,
abstract = {{Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with an increased risk of coronary artery disease. To date, data regarding possible associations between plasma Gal-4 and stroke are lacking. Using linear and logistic regression analyses, we tested Gal-4 association with prevalent stroke in a population-based cohort. Additionally, in mice fed a high-fat diet (HFD), we investigated whether plasma Gal-4 increases in response to ischemic stroke. Plasma Gal-4 was higher in subjects with prevalent ischemic stroke, and was associated with prevalent ischemic stroke (odds ratio 1.52; 95% confidence interval 1.01–2.30; p = 0.048) adjusted for age, sex, and covariates of cardiometabolic health. Plasma Gal-4 increased after experimental stroke in both controls and HFD-fed mice. HFD exposure was devoid of impact on Gal-4 levels. This study demonstrates higher plasma Gal-4 levels in both experimental stroke and in humans that experienced ischemic stroke.}},
author = {{Jujic, Amra and Vieira, João and Matuskova, Hana and Nilsson, Peter M and Lindblad, Ulf and Olsen, Michael H. and Duarte, Joao and Meissner, Anja and Magnusson, Martin}},
issn = {{1422-0067}},
language = {{eng}},
month = {{05}},
number = {{12}},
publisher = {{MDPI AG}},
series = {{International Journal of Molecular Sciences}},
title = {{Plasma Galectin-4 Levels Are Increased after Stroke in Mice and Humans}},
url = {{http://dx.doi.org/10.3390/ijms241210064}},
doi = {{10.3390/ijms241210064}},
volume = {{24}},
year = {{2023}},
}