Clinicopathological concordance in cognitive disease diagnostics
Andersson, Elin Möller LU ; Hoff, Elin Johansson ; Waldö, Maria Landqvist LU and Englund, Elisabet LU
(2020)
In Clinical Neuropathology
39(3).
p.99-104
- Abstract
Neurocognitive disorder encompasses many separate diagnoses, such as frontotemporal dementia (FTD), Alzheimer's disease (AD), Lewy body dementia (LBD), vascular dementia (VaD), and mixed dementia (MD). Because of the many variations between and within each subtype, it may be a challenge to clinically diagnose each condition. In a previous study on 176 dementia patients in a university hospital cohort between the years 1996 and 2006, a full diagnostic concordance of 49% was demonstrated between clinical diagnoses and pathological morphology [1]. The aims of this study were to do a follow-up on diagnostic concordance from the subsequent 10 years (2007 - 2016) and to compare the results with the previous study from 2009. In all cases of... (More)
Neurocognitive disorder encompasses many separate diagnoses, such as frontotemporal dementia (FTD), Alzheimer's disease (AD), Lewy body dementia (LBD), vascular dementia (VaD), and mixed dementia (MD). Because of the many variations between and within each subtype, it may be a challenge to clinically diagnose each condition. In a previous study on 176 dementia patients in a university hospital cohort between the years 1996 and 2006, a full diagnostic concordance of 49% was demonstrated between clinical diagnoses and pathological morphology [1]. The aims of this study were to do a follow-up on diagnostic concordance from the subsequent 10 years (2007 - 2016) and to compare the results with the previous study from 2009. In all cases of neuropathologically diagnosed dementia disorders (n = 324), the clinical records were searched for information on the clinical diagnosis of dementia, including on subtype. All individuals who had been diagnosed by a specialist were selected (n = 210). In this study, a full concordance between clinical diagnoses and neuropathological morphology was found in 61% of individuals, with marked variations between subgroups, including the lowest (31%) in the group of VaD. Vigilance in clinicopathological concordance is important for quality maintenance as well as the improvement of skills in diagnostic work. In light of the previous study, VaD one decade later remains elusive. The unmasking of this complicated and multifaceted disorder may be beneficial to the overall diagnostic accuracy in cognitive disease investigations.
(Less)
- author
- Andersson, Elin Möller
LU
; Hoff, Elin Johansson
; Waldö, Maria Landqvist
LU
and Englund, Elisabet
LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Autopsy, Clinical records, Clinicopathological concordance, Dementia, Neuropathology
- in
- Clinical Neuropathology
- volume
- 39
- issue
- 3
- pages
- 6 pages
- publisher
- Dustri-Verlag
- external identifiers
-
- scopus:85084167196
- pmid:31983385
- ISSN
- 0722-5091
- DOI
- 10.5414/NP301204
- language
- English
- LU publication?
- yes
- id
- 8dce5ef2-106b-48f2-8234-c4fbd4685261
- date added to LUP
- 2021-01-11 12:45:27
- date last changed
- 2024-03-05 17:50:37
@article{8dce5ef2-106b-48f2-8234-c4fbd4685261,
abstract = {{<p>Neurocognitive disorder encompasses many separate diagnoses, such as frontotemporal dementia (FTD), Alzheimer's disease (AD), Lewy body dementia (LBD), vascular dementia (VaD), and mixed dementia (MD). Because of the many variations between and within each subtype, it may be a challenge to clinically diagnose each condition. In a previous study on 176 dementia patients in a university hospital cohort between the years 1996 and 2006, a full diagnostic concordance of 49% was demonstrated between clinical diagnoses and pathological morphology [1]. The aims of this study were to do a follow-up on diagnostic concordance from the subsequent 10 years (2007 - 2016) and to compare the results with the previous study from 2009. In all cases of neuropathologically diagnosed dementia disorders (n = 324), the clinical records were searched for information on the clinical diagnosis of dementia, including on subtype. All individuals who had been diagnosed by a specialist were selected (n = 210). In this study, a full concordance between clinical diagnoses and neuropathological morphology was found in 61% of individuals, with marked variations between subgroups, including the lowest (31%) in the group of VaD. Vigilance in clinicopathological concordance is important for quality maintenance as well as the improvement of skills in diagnostic work. In light of the previous study, VaD one decade later remains elusive. The unmasking of this complicated and multifaceted disorder may be beneficial to the overall diagnostic accuracy in cognitive disease investigations.</p>}},
author = {{Andersson, Elin Möller and Hoff, Elin Johansson and Waldö, Maria Landqvist and Englund, Elisabet}},
issn = {{0722-5091}},
keywords = {{Autopsy; Clinical records; Clinicopathological concordance; Dementia; Neuropathology}},
language = {{eng}},
number = {{3}},
pages = {{99--104}},
publisher = {{Dustri-Verlag}},
series = {{Clinical Neuropathology}},
title = {{Clinicopathological concordance in cognitive disease diagnostics}},
url = {{http://dx.doi.org/10.5414/NP301204}},
doi = {{10.5414/NP301204}},
volume = {{39}},
year = {{2020}},
}