Sleep and circadian rhythm regulation in early Parkinson disease
(2014) In JAMA Neurology 71(5). p.95-589- Abstract
IMPORTANCE: Sleep disturbances are recognized as a common nonmotor complaint in Parkinson disease but their etiology is poorly understood.
OBJECTIVE: To define the sleep and circadian phenotype of patients with early-stage Parkinson disease.
DESIGN, SETTING, AND PARTICIPANTS: Initial assessment of sleep characteristics in a large population-representative incident Parkinson disease cohort (N=239) at the University of Cambridge, England, followed by further comprehensive case-control sleep assessments in a subgroup of these patients (n=30) and matched controls (n=15).
MAIN OUTCOMES AND MEASURES: Sleep diagnoses and sleep architecture based on polysomnography studies, actigraphy assessment, and 24-hour analyses of serum... (More)
IMPORTANCE: Sleep disturbances are recognized as a common nonmotor complaint in Parkinson disease but their etiology is poorly understood.
OBJECTIVE: To define the sleep and circadian phenotype of patients with early-stage Parkinson disease.
DESIGN, SETTING, AND PARTICIPANTS: Initial assessment of sleep characteristics in a large population-representative incident Parkinson disease cohort (N=239) at the University of Cambridge, England, followed by further comprehensive case-control sleep assessments in a subgroup of these patients (n=30) and matched controls (n=15).
MAIN OUTCOMES AND MEASURES: Sleep diagnoses and sleep architecture based on polysomnography studies, actigraphy assessment, and 24-hour analyses of serum cortisol, melatonin, and peripheral clock gene expression (Bmal1, Per2, and Rev-Erbα).
RESULTS: Subjective sleep complaints were present in almost half of newly diagnosed patients and correlated significantly with poorer quality of life. Patients with Parkinson disease exhibited increased sleep latency (P = .04), reduced sleep efficiency (P = .008), and reduced rapid eye movement sleep (P = .02). In addition, there was a sustained elevation of serum cortisol levels, reduced circulating melatonin levels, and altered Bmal1 expression in patients with Parkinson disease compared with controls.
CONCLUSIONS AND RELEVANCE: Sleep dysfunction seen in early Parkinson disease may reflect a more fundamental pathology in the molecular clock underlying circadian rhythms.
(Less)
- author
- Breen, David P ; Vuono, Romina ; Nawarathna, Upekshani ; Fisher, Kate ; Shneerson, John M ; Reddy, Akhilesh B and Barker, Roger A LU
- organization
- publishing date
- 2014-05
- type
- Contribution to journal
- publication status
- published
- keywords
- Aged, Case-Control Studies, Circadian Rhythm, Cohort Studies, Early Diagnosis, Female, Humans, Male, Middle Aged, Parkinson Disease, Sleep, Sleep Disorders, Circadian Rhythm, Journal Article, Research Support, Non-U.S. Gov't
- in
- JAMA Neurology
- volume
- 71
- issue
- 5
- pages
- 7 pages
- publisher
- American Medical Association
- external identifiers
-
- scopus:84900478730
- pmid:24687146
- ISSN
- 2168-6157
- DOI
- 10.1001/jamaneurol.2014.65
- language
- English
- LU publication?
- no
- id
- 8e3e35d5-a3ee-468f-ab0e-a5be54e8fac6
- date added to LUP
- 2016-11-24 15:10:00
- date last changed
- 2024-09-07 02:37:50
@article{8e3e35d5-a3ee-468f-ab0e-a5be54e8fac6, abstract = {{<p>IMPORTANCE: Sleep disturbances are recognized as a common nonmotor complaint in Parkinson disease but their etiology is poorly understood.</p><p>OBJECTIVE: To define the sleep and circadian phenotype of patients with early-stage Parkinson disease.</p><p>DESIGN, SETTING, AND PARTICIPANTS: Initial assessment of sleep characteristics in a large population-representative incident Parkinson disease cohort (N=239) at the University of Cambridge, England, followed by further comprehensive case-control sleep assessments in a subgroup of these patients (n=30) and matched controls (n=15).</p><p>MAIN OUTCOMES AND MEASURES: Sleep diagnoses and sleep architecture based on polysomnography studies, actigraphy assessment, and 24-hour analyses of serum cortisol, melatonin, and peripheral clock gene expression (Bmal1, Per2, and Rev-Erbα).</p><p>RESULTS: Subjective sleep complaints were present in almost half of newly diagnosed patients and correlated significantly with poorer quality of life. Patients with Parkinson disease exhibited increased sleep latency (P = .04), reduced sleep efficiency (P = .008), and reduced rapid eye movement sleep (P = .02). In addition, there was a sustained elevation of serum cortisol levels, reduced circulating melatonin levels, and altered Bmal1 expression in patients with Parkinson disease compared with controls.</p><p>CONCLUSIONS AND RELEVANCE: Sleep dysfunction seen in early Parkinson disease may reflect a more fundamental pathology in the molecular clock underlying circadian rhythms.</p>}}, author = {{Breen, David P and Vuono, Romina and Nawarathna, Upekshani and Fisher, Kate and Shneerson, John M and Reddy, Akhilesh B and Barker, Roger A}}, issn = {{2168-6157}}, keywords = {{Aged; Case-Control Studies; Circadian Rhythm; Cohort Studies; Early Diagnosis; Female; Humans; Male; Middle Aged; Parkinson Disease; Sleep; Sleep Disorders, Circadian Rhythm; Journal Article; Research Support, Non-U.S. Gov't}}, language = {{eng}}, number = {{5}}, pages = {{95--589}}, publisher = {{American Medical Association}}, series = {{JAMA Neurology}}, title = {{Sleep and circadian rhythm regulation in early Parkinson disease}}, url = {{http://dx.doi.org/10.1001/jamaneurol.2014.65}}, doi = {{10.1001/jamaneurol.2014.65}}, volume = {{71}}, year = {{2014}}, }