History of cellular grafting for central nervous system repair—A clinical perspective
(2024) In Handbook of Clinical Neurology 205. p.15-40- Abstract
As late as in the 1970s, the evidence supporting that brain function might be restored by replacing dead cells by transplantation of new healthy cells was scarce in experimental animals and lacking in humans. Repairing the human brain was regarded as completely unrealistic by clinicians. Fifty years later, the situation is very different, and cellular grafting has reached patient application in several conditions affecting the CNS. The clinical studies performed so far have shown that cellular grafts can survive, grow, and function also in the diseased adult human brain. However, no proven treatment based on cell transplantation is currently available for any brain disorder. Here, the history of cellular grafting is described from a... (More)
As late as in the 1970s, the evidence supporting that brain function might be restored by replacing dead cells by transplantation of new healthy cells was scarce in experimental animals and lacking in humans. Repairing the human brain was regarded as completely unrealistic by clinicians. Fifty years later, the situation is very different, and cellular grafting has reached patient application in several conditions affecting the CNS. The clinical studies performed so far have shown that cellular grafts can survive, grow, and function also in the diseased adult human brain. However, no proven treatment based on cell transplantation is currently available for any brain disorder. Here, the history of cellular grafting is described from a clinical perspective, including some of the preclinical work that has formed the basis for its translation to patient application. The focus is on cell transplantation for Parkinson disease, which in many ways is paving the way for this field of research. The chapter gives an account of the scientific milestones, the ups and downs, as well as the positive and negative reactions from the scientific and clinical community, and how this research field despite many obstacles has continued to move forward over more than four decades.
(Less)
- author
- Lindvall, Olle LU
- organization
- publishing date
- 2024-01
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Adrenal medulla, Dopamine neurons, Dyskinesias, Fetal tissue, Parkinson disease, Positron emission tomography, Stem cells, Striatum, Transplantation
- host publication
- Handbook of Clinical Neurology
- series title
- Handbook of Clinical Neurology
- volume
- 205
- pages
- 26 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:39341652
- scopus:85204673812
- ISSN
- 2212-4152
- 0072-9752
- DOI
- 10.1016/B978-0-323-90120-8.00011-3
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2024 Elsevier B.V.
- id
- 8f0e14dc-2f13-4b6d-9ddf-3fd9879eb867
- date added to LUP
- 2024-12-03 08:23:36
- date last changed
- 2025-07-02 01:46:42
@inbook{8f0e14dc-2f13-4b6d-9ddf-3fd9879eb867,
abstract = {{<p>As late as in the 1970s, the evidence supporting that brain function might be restored by replacing dead cells by transplantation of new healthy cells was scarce in experimental animals and lacking in humans. Repairing the human brain was regarded as completely unrealistic by clinicians. Fifty years later, the situation is very different, and cellular grafting has reached patient application in several conditions affecting the CNS. The clinical studies performed so far have shown that cellular grafts can survive, grow, and function also in the diseased adult human brain. However, no proven treatment based on cell transplantation is currently available for any brain disorder. Here, the history of cellular grafting is described from a clinical perspective, including some of the preclinical work that has formed the basis for its translation to patient application. The focus is on cell transplantation for Parkinson disease, which in many ways is paving the way for this field of research. The chapter gives an account of the scientific milestones, the ups and downs, as well as the positive and negative reactions from the scientific and clinical community, and how this research field despite many obstacles has continued to move forward over more than four decades.</p>}},
author = {{Lindvall, Olle}},
booktitle = {{Handbook of Clinical Neurology}},
issn = {{2212-4152}},
keywords = {{Adrenal medulla; Dopamine neurons; Dyskinesias; Fetal tissue; Parkinson disease; Positron emission tomography; Stem cells; Striatum; Transplantation}},
language = {{eng}},
pages = {{15--40}},
publisher = {{Elsevier}},
series = {{Handbook of Clinical Neurology}},
title = {{History of cellular grafting for central nervous system repair—A clinical perspective}},
url = {{http://dx.doi.org/10.1016/B978-0-323-90120-8.00011-3}},
doi = {{10.1016/B978-0-323-90120-8.00011-3}},
volume = {{205}},
year = {{2024}},
}