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Tear menisci and corneal subbasal nerve density in patients after laser in situ keratomileusis

Hu, L. ; Xie, W. ; Liu, J. ; Zhou, Y. ; Zhou, Q. LU orcid ; Yu, Y. ; Chen, J. and Lu, F. (2015) In Eye and Contact Lens 41(1). p.51-57
Abstract
Objective: To investigate the relationship between tear menisci and corneal nerve density in patients after laser in situ keratomileusis (LASIK). Methods: Twenty-eight eyes of 14 myopic patients were enrolled. Height and area of the upper and lower tear menisci—upper tear meniscus height, upper tear meniscus area, lower tear meniscus height (LTMH), and lower tear meniscus area (LTMA)—were measured by spectral domain optical coherence tomography before surgery, 1 week, 1 month, and 3 months after surgery. Central, temporal, and nasal corneal nerve densities were measured by confocal microscopy before surgery, 1 month, and 3 months after surgery. Results: After surgery, LTMH and LTMA increased significantly from 1 week to 1 month (P=0.009... (More)
Objective: To investigate the relationship between tear menisci and corneal nerve density in patients after laser in situ keratomileusis (LASIK). Methods: Twenty-eight eyes of 14 myopic patients were enrolled. Height and area of the upper and lower tear menisci—upper tear meniscus height, upper tear meniscus area, lower tear meniscus height (LTMH), and lower tear meniscus area (LTMA)—were measured by spectral domain optical coherence tomography before surgery, 1 week, 1 month, and 3 months after surgery. Central, temporal, and nasal corneal nerve densities were measured by confocal microscopy before surgery, 1 month, and 3 months after surgery. Results: After surgery, LTMH and LTMA increased significantly from 1 week to 1 month (P=0.009 and =0.011, respectively) and 1 month to 3 months (P=0.003 and =0.039, respectively); temporal and nasal nerve densities increased significantly from 1 month to 3 months (P<0.001, P=0.016, respectively). Lower tear meniscus area was significantly correlated with central and nasal nerve densities at 1 month (R=0.478 and 0.46, P=0.01 and 0.014, respectively), whereas LTMH and LTMA at 3 months were significantly correlated with central nerve density at 1 month (R=0.449 and 0.608, P=0.017 and 0.001, respectively). Conclusions: Lower tear menisci and peripheral corneal nerves recovered continually after LASIK during the early stage. However, tear volume might depend on residual central corneal nerves at 1 month, rather than on corneal nerve recovery. (Less)
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Contribution to journal
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published
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in
Eye and Contact Lens
volume
41
issue
1
pages
7 pages
external identifiers
  • scopus:84920870207
DOI
10.1097/ICL.0000000000000062
language
English
LU publication?
no
id
8f207f11-8147-4fb4-b5ea-0531e15a1dd2
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-84920870207&doi=10.1097%2fICL.0000000000000062&partnerID=40&md5=813d39b8dd6515366630307b87bd984e
date added to LUP
2020-01-27 10:14:18
date last changed
2022-02-01 03:14:15
@article{8f207f11-8147-4fb4-b5ea-0531e15a1dd2,
  abstract     = {{Objective: To investigate the relationship between tear menisci and corneal nerve density in patients after laser in situ keratomileusis (LASIK). Methods: Twenty-eight eyes of 14 myopic patients were enrolled. Height and area of the upper and lower tear menisci—upper tear meniscus height, upper tear meniscus area, lower tear meniscus height (LTMH), and lower tear meniscus area (LTMA)—were measured by spectral domain optical coherence tomography before surgery, 1 week, 1 month, and 3 months after surgery. Central, temporal, and nasal corneal nerve densities were measured by confocal microscopy before surgery, 1 month, and 3 months after surgery. Results: After surgery, LTMH and LTMA increased significantly from 1 week to 1 month (P=0.009 and =0.011, respectively) and 1 month to 3 months (P=0.003 and =0.039, respectively); temporal and nasal nerve densities increased significantly from 1 month to 3 months (P&lt;0.001, P=0.016, respectively). Lower tear meniscus area was significantly correlated with central and nasal nerve densities at 1 month (R=0.478 and 0.46, P=0.01 and 0.014, respectively), whereas LTMH and LTMA at 3 months were significantly correlated with central nerve density at 1 month (R=0.449 and 0.608, P=0.017 and 0.001, respectively). Conclusions: Lower tear menisci and peripheral corneal nerves recovered continually after LASIK during the early stage. However, tear volume might depend on residual central corneal nerves at 1 month, rather than on corneal nerve recovery.}},
  author       = {{Hu, L. and Xie, W. and Liu, J. and Zhou, Y. and Zhou, Q. and Yu, Y. and Chen, J. and Lu, F.}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{51--57}},
  series       = {{Eye and Contact Lens}},
  title        = {{Tear menisci and corneal subbasal nerve density in patients after laser in situ keratomileusis}},
  url          = {{http://dx.doi.org/10.1097/ICL.0000000000000062}},
  doi          = {{10.1097/ICL.0000000000000062}},
  volume       = {{41}},
  year         = {{2015}},
}