Biokinetics of iodide in man: Refinement of current ICRP dosimetry models
(2003) In Cancer Biotherapy & Radiopharmaceuticals 18(3). p.445-450- Abstract
- A compartmental model describing the distribution and retention of radioactive iodide in thyroid and other organs is presented. The model is developed from published ICRP models. It is designed primarily for radiation dosimetry of iodine radionuclides used in nuclear medicine, but may also be useful for occupational radiation protection. In the proposed model, the distribution of iodide to the thyroid is assumed to be more rapid than in earlier models. Uptakes in stomach wall and salivary glands are considered, and the absorbed doses to these organs calculated. The partitioning of iodide between stomach wall and content is also discussed. Recirculation of organic iodine is also taken into account. Age-dependent half-times for iodide in the... (More)
- A compartmental model describing the distribution and retention of radioactive iodide in thyroid and other organs is presented. The model is developed from published ICRP models. It is designed primarily for radiation dosimetry of iodine radionuclides used in nuclear medicine, but may also be useful for occupational radiation protection. In the proposed model, the distribution of iodide to the thyroid is assumed to be more rapid than in earlier models. Uptakes in stomach wall and salivary glands are considered, and the absorbed doses to these organs calculated. The partitioning of iodide between stomach wall and content is also discussed. Recirculation of organic iodine is also taken into account. Age-dependent half-times for iodide in the thyroid, as well as for organically-bound iodine are presented. The proposed model is applicable for dose estimations with different uptakes in the thyroid as well as for the situation when the thyroid is blocked, completely or incompletely. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/900126
- author
- Johansson, L ; Leide Svegborn, Sigrid LU ; Mattsson, Sören LU and Nosslin, Bertil LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- iodide, radiation, internal dosimetry, biokinetic model
- in
- Cancer Biotherapy & Radiopharmaceuticals
- volume
- 18
- issue
- 3
- pages
- 445 - 450
- publisher
- Mary Ann Liebert, Inc.
- external identifiers
-
- wos:000184373900015
- pmid:12954132
- scopus:0041742308
- ISSN
- 1557-8852
- DOI
- 10.1089/108497803322285206
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Radiation Physics, Malmö (013243210), Emergency medicine/Medicine/Surgery (013240200)
- id
- 2d749985-4e47-424d-972e-bb91f9c7a508 (old id 900126)
- date added to LUP
- 2016-04-01 16:50:25
- date last changed
- 2022-01-28 22:33:55
@article{2d749985-4e47-424d-972e-bb91f9c7a508,
abstract = {{A compartmental model describing the distribution and retention of radioactive iodide in thyroid and other organs is presented. The model is developed from published ICRP models. It is designed primarily for radiation dosimetry of iodine radionuclides used in nuclear medicine, but may also be useful for occupational radiation protection. In the proposed model, the distribution of iodide to the thyroid is assumed to be more rapid than in earlier models. Uptakes in stomach wall and salivary glands are considered, and the absorbed doses to these organs calculated. The partitioning of iodide between stomach wall and content is also discussed. Recirculation of organic iodine is also taken into account. Age-dependent half-times for iodide in the thyroid, as well as for organically-bound iodine are presented. The proposed model is applicable for dose estimations with different uptakes in the thyroid as well as for the situation when the thyroid is blocked, completely or incompletely.}},
author = {{Johansson, L and Leide Svegborn, Sigrid and Mattsson, Sören and Nosslin, Bertil}},
issn = {{1557-8852}},
keywords = {{iodide; radiation; internal dosimetry; biokinetic model}},
language = {{eng}},
number = {{3}},
pages = {{445--450}},
publisher = {{Mary Ann Liebert, Inc.}},
series = {{Cancer Biotherapy & Radiopharmaceuticals}},
title = {{Biokinetics of iodide in man: Refinement of current ICRP dosimetry models}},
url = {{http://dx.doi.org/10.1089/108497803322285206}},
doi = {{10.1089/108497803322285206}},
volume = {{18}},
year = {{2003}},
}