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Orthostatic hypotension and novel blood pressure associated gene variants in older adults : data from the TILDA Study

Laird, Eamon ; O'Halloran, Aisling M ; Fedorowski, Artur LU orcid ; Melander, Olle LU orcid ; Hever, Ann ; Sjögren, Marketa LU ; Carey, Daniel and Kenny, Rose Anne (2020) In Journals of Gerontology. Series A: Biological Sciences & Medical Sciences 75(11). p.2074-2080
Abstract

Orthostatic hypotension (OH) is associated with increased risk of trauma and cardiovascular events. Recent studies have identified new genetic variants that influence orthostatic blood pressure (BP). The aim of this study was to investigate the associations of candidate gene loci with orthostatic BP responses in older adults. A total of 3,430 participants aged ≥50 years from The Irish Longitudinal Study on Ageing (TILDA) with BP measures and genetic data from twelve single-nucleotide polymorphism (SNP) linked to BP responses were analysed. Orthostatic BP responses were recorded at each 10 second interval and were defined as OH (SBP drop ≥20mmHg or DBP drop ≥10mmHg) at the time-points 40, 90 and 110 seconds. We defined sustained OH (SOH)... (More)

Orthostatic hypotension (OH) is associated with increased risk of trauma and cardiovascular events. Recent studies have identified new genetic variants that influence orthostatic blood pressure (BP). The aim of this study was to investigate the associations of candidate gene loci with orthostatic BP responses in older adults. A total of 3,430 participants aged ≥50 years from The Irish Longitudinal Study on Ageing (TILDA) with BP measures and genetic data from twelve single-nucleotide polymorphism (SNP) linked to BP responses were analysed. Orthostatic BP responses were recorded at each 10 second interval and were defined as OH (SBP drop ≥20mmHg or DBP drop ≥10mmHg) at the time-points 40, 90 and 110 seconds. We defined sustained OH (SOH) as a drop that exceeded consensus BP thresholds for OH at 40, 90 and 110 seconds after standing. Logistic regression analyses modelled associations between the candidate SNP alleles and OH. We report no significant associations between OH and measured SNPs after correction for multiple comparisons apart from the SNP rs5068 where proportions of the minor allele was significantly different between cases and controls for SOH 40 (p=0.002). After adjustment for covariates in a logistic regression, those with the minor G allele (compared to the A allele) had a decreased incidence rate ratio (IRR) for SOH 40 (IRR 0.45, p=0.001, 95% CI 0.29-0.72). Only one SNP linked with increased natriuretic peptide concentrations was associated with OH. These results suggest that genetic variants may have a weak impact on OH but needs verification in other population studies.

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organization
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Contribution to journal
publication status
published
subject
in
Journals of Gerontology. Series A: Biological Sciences & Medical Sciences
volume
75
issue
11
pages
2074 - 2080
publisher
Oxford University Press
external identifiers
  • scopus:85093538688
  • pmid:31821404
ISSN
1758-535X
DOI
10.1093/gerona/glz286
language
English
LU publication?
yes
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© The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
id
94cfc8ba-2cfb-4c3a-bd7a-af3a989dceea
date added to LUP
2020-01-22 00:11:52
date last changed
2025-01-09 06:08:30
@article{94cfc8ba-2cfb-4c3a-bd7a-af3a989dceea,
  abstract     = {{<p>Orthostatic hypotension (OH) is associated with increased risk of trauma and cardiovascular events. Recent studies have identified new genetic variants that influence orthostatic blood pressure (BP). The aim of this study was to investigate the associations of candidate gene loci with orthostatic BP responses in older adults. A total of 3,430 participants aged ≥50 years from The Irish Longitudinal Study on Ageing (TILDA) with BP measures and genetic data from twelve single-nucleotide polymorphism (SNP) linked to BP responses were analysed. Orthostatic BP responses were recorded at each 10 second interval and were defined as OH (SBP drop ≥20mmHg or DBP drop ≥10mmHg) at the time-points 40, 90 and 110 seconds. We defined sustained OH (SOH) as a drop that exceeded consensus BP thresholds for OH at 40, 90 and 110 seconds after standing. Logistic regression analyses modelled associations between the candidate SNP alleles and OH. We report no significant associations between OH and measured SNPs after correction for multiple comparisons apart from the SNP rs5068 where proportions of the minor allele was significantly different between cases and controls for SOH 40 (p=0.002). After adjustment for covariates in a logistic regression, those with the minor G allele (compared to the A allele) had a decreased incidence rate ratio (IRR) for SOH 40 (IRR 0.45, p=0.001, 95% CI 0.29-0.72). Only one SNP linked with increased natriuretic peptide concentrations was associated with OH. These results suggest that genetic variants may have a weak impact on OH but needs verification in other population studies.</p>}},
  author       = {{Laird, Eamon and O'Halloran, Aisling M and Fedorowski, Artur and Melander, Olle and Hever, Ann and Sjögren, Marketa and Carey, Daniel and Kenny, Rose Anne}},
  issn         = {{1758-535X}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{2074--2080}},
  publisher    = {{Oxford University Press}},
  series       = {{Journals of Gerontology. Series A: Biological Sciences & Medical Sciences}},
  title        = {{Orthostatic hypotension and novel blood pressure associated gene variants in older adults : data from the TILDA Study}},
  url          = {{http://dx.doi.org/10.1093/gerona/glz286}},
  doi          = {{10.1093/gerona/glz286}},
  volume       = {{75}},
  year         = {{2020}},
}