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[18F]PSMA-1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate

Valind, Kristian LU orcid ; Jögi, Jonas LU orcid ; Minarik, David LU and Trägårdh, Elin LU (2023) In Clinical Physiology and Functional Imaging 43(2). p.128-135
Abstract
Background
Scintigraphy with technetium-99m-labelled dimercaptosuccinic acid ([99mTc]Tc-DMSA) is widely used for renal cortical imaging. Uptake of [99mTc]Tc-DMSA has been shown to correlate with glomerular filtration rate (GFR). Prostate-specific membrane antigen (PSMA) radiopharmaceuticals used for positron emission tomography (PET) show high renal uptake and are being investigated for renal imaging. [68Ga]Ga-PSMA-11 PET parameters have been shown to correlate with estimated GFR (eGFR). The aim of this study was to investigate the relationship between renal [18F]PSMA-1007 uptake and eGFR.

Methods
Hundred and eighty-five patients underwent PET imaging at 1 and 2 h after injection of 4.0 ± 0.2 MBq [18F]PSMA-1007. Serum... (More)
Background
Scintigraphy with technetium-99m-labelled dimercaptosuccinic acid ([99mTc]Tc-DMSA) is widely used for renal cortical imaging. Uptake of [99mTc]Tc-DMSA has been shown to correlate with glomerular filtration rate (GFR). Prostate-specific membrane antigen (PSMA) radiopharmaceuticals used for positron emission tomography (PET) show high renal uptake and are being investigated for renal imaging. [68Ga]Ga-PSMA-11 PET parameters have been shown to correlate with estimated GFR (eGFR). The aim of this study was to investigate the relationship between renal [18F]PSMA-1007 uptake and eGFR.

Methods
Hundred and eighty-five patients underwent PET imaging at 1 and 2 h after injection of 4.0 ± 0.2 MBq [18F]PSMA-1007. Serum creatinine levels were measured and GFR estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations. Fifteen patients were excluded due to missing or incorrect data. Thus, data from 170 patients were analyzed. Kidneys were segmented in the PET images using a convolutional neural network with manual correction. For each kidney, mean standardized uptake value (SUVmean) and segmentation volume in millilitres were measured. Linear regression analyses were performed with eGFR as the outcome variable.

Results
Variation in the eGFR values was explained to a significant degree by SUVmean and renal segmentation volume in both the 1 and 2 h images. This correlation was stronger for CKD-EPI eGFR (1 h R2 = 0.64; 2 h R2 = 0.64) than for MDRD eGFR (1 h R2 = 0.47; 2 h R2 = 0.45).

Conclusion
Renal [18F]PSMA-1007 uptake parameters correlate with eGFR and are indicative of renal cortical function. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Physiology and Functional Imaging
volume
43
issue
2
pages
128 - 135
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85142601351
  • pmid:36385577
ISSN
1475-097X
DOI
10.1111/cpf.12801
project
New methods for tomographic functional imaging of the renal cortex
language
English
LU publication?
yes
id
96b0fe5a-71ab-4882-96ce-aa76b0ee02a8
date added to LUP
2022-11-26 16:37:03
date last changed
2023-10-26 14:56:19
@article{96b0fe5a-71ab-4882-96ce-aa76b0ee02a8,
  abstract     = {{Background<br/>Scintigraphy with technetium-99m-labelled dimercaptosuccinic acid ([99mTc]Tc-DMSA) is widely used for renal cortical imaging. Uptake of [99mTc]Tc-DMSA has been shown to correlate with glomerular filtration rate (GFR). Prostate-specific membrane antigen (PSMA) radiopharmaceuticals used for positron emission tomography (PET) show high renal uptake and are being investigated for renal imaging. [68Ga]Ga-PSMA-11 PET parameters have been shown to correlate with estimated GFR (eGFR). The aim of this study was to investigate the relationship between renal [18F]PSMA-1007 uptake and eGFR.<br/><br/>Methods<br/>Hundred and eighty-five patients underwent PET imaging at 1 and 2 h after injection of 4.0 ± 0.2 MBq [18F]PSMA-1007. Serum creatinine levels were measured and GFR estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations. Fifteen patients were excluded due to missing or incorrect data. Thus, data from 170 patients were analyzed. Kidneys were segmented in the PET images using a convolutional neural network with manual correction. For each kidney, mean standardized uptake value (SUVmean) and segmentation volume in millilitres were measured. Linear regression analyses were performed with eGFR as the outcome variable.<br/><br/>Results<br/>Variation in the eGFR values was explained to a significant degree by SUVmean and renal segmentation volume in both the 1 and 2 h images. This correlation was stronger for CKD-EPI eGFR (1 h R2 = 0.64; 2 h R2 = 0.64) than for MDRD eGFR (1 h R2 = 0.47; 2 h R2 = 0.45).<br/><br/>Conclusion<br/>Renal [18F]PSMA-1007 uptake parameters correlate with eGFR and are indicative of renal cortical function.}},
  author       = {{Valind, Kristian and Jögi, Jonas and Minarik, David and Trägårdh, Elin}},
  issn         = {{1475-097X}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{128--135}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Clinical Physiology and Functional Imaging}},
  title        = {{[18F]PSMA-1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate}},
  url          = {{http://dx.doi.org/10.1111/cpf.12801}},
  doi          = {{10.1111/cpf.12801}},
  volume       = {{43}},
  year         = {{2023}},
}