Assessing Risks of Glaucoma
(2022) In Lund University, Faculty of Medicine Doctoral Dissertation Series- Abstract
- Glaucoma is a potentially blinding disease where the affected individual often first
notices symptoms when the disease has reached a late stage. If glaucoma is detected
early e.g., at screening, the risk for visual impairment can be reduced. There are many
factors that affect a patient´s risk of developing glaucoma or visual impairment due to
glaucoma. In the four studies of this thesis, the general aim was to evaluate such factors, focussing mainly on age, intraocular pressure and severity at detection, to provide more information on the need for improved case detection.
The objectives of Study I and IV were to report the prevalence and severity of
undetected glaucoma in different age groups when detected at... (More) - Glaucoma is a potentially blinding disease where the affected individual often first
notices symptoms when the disease has reached a late stage. If glaucoma is detected
early e.g., at screening, the risk for visual impairment can be reduced. There are many
factors that affect a patient´s risk of developing glaucoma or visual impairment due to
glaucoma. In the four studies of this thesis, the general aim was to evaluate such factors, focussing mainly on age, intraocular pressure and severity at detection, to provide more information on the need for improved case detection.
The objectives of Study I and IV were to report the prevalence and severity of
undetected glaucoma in different age groups when detected at screening. Study I was
based on data originally collected in a large population screening for individuals 57-77 years old performed in 1992-1997. In Study IV, 322 elderly subjects 77-89 years old were screened for glaucoma in 2019-2021. We found that the prevalence of undetected glaucoma increased with age but disease severity was similar at 60-77 years of age with about 30% of glaucomatous eyes with advanced disease or worse, but mostly early in elderly patients 77-89 years old.
Using the large screening material from 1992-1997 that included 32,918 subjects, we
created a regression model for the prediction of undetected glaucoma based on the
combined effect of age and intraocular pressure (Study II). Glaucoma increased
exponentially with age and intraocular pressure.
Study III aimed to find the lifetime risk of glaucoma visual impairment in individuals
followed-up for raised intraocular pressure since the 1980s. We found that only 9% of
subjects developed bilateral visual impairment and 3% bilateral blindness resulting
from glaucoma.
The results are of value when estimating the need for improved glaucoma detection and when considering the management of patients with raised intraocular pressure. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/9cf0a8ba-fd46-4152-8ef8-3c1b99e70abc
- author
- Oskarsdottir, Sigridur LU
- supervisor
-
- Boel Bengtsson LU
- Anders Heijl LU
- Patrik Midlöv LU
- opponent
-
- Docent Harju, Mika, University of Helsinki
- organization
- publishing date
- 2022
- type
- Thesis
- publication status
- published
- subject
- keywords
- Glaucoma, Glaucoma stages, Ocular hypertension, Prevalence, Visual impairment, Prediction model, Lifetime risk, Undetected glaucoma, Screening
- in
- Lund University, Faculty of Medicine Doctoral Dissertation Series
- issue
- 2022:26
- pages
- 68 pages
- publisher
- Lund University, Faculty of Medicine
- defense location
- Agardh föreläsningssal, CRC, Jan Waldenströms gata 35, Skånes Universitetssjukhus i Malmö. Join by Zoom: https://lu-se.zoom.us/j/65983316806
- defense date
- 2022-03-11 13:00:00
- ISSN
- 1652-8220
- ISBN
- 978-91-8021-187-1
- language
- English
- LU publication?
- yes
- id
- 9cf0a8ba-fd46-4152-8ef8-3c1b99e70abc
- date added to LUP
- 2022-02-10 18:26:38
- date last changed
- 2022-02-18 14:25:57
@phdthesis{9cf0a8ba-fd46-4152-8ef8-3c1b99e70abc, abstract = {{Glaucoma is a potentially blinding disease where the affected individual often first<br/>notices symptoms when the disease has reached a late stage. If glaucoma is detected<br/>early e.g., at screening, the risk for visual impairment can be reduced. There are many<br/>factors that affect a patient´s risk of developing glaucoma or visual impairment due to<br/>glaucoma. In the four studies of this thesis, the general aim was to evaluate such factors, focussing mainly on age, intraocular pressure and severity at detection, to provide more information on the need for improved case detection.<br/>The objectives of Study I and IV were to report the prevalence and severity of<br/>undetected glaucoma in different age groups when detected at screening. Study I was<br/>based on data originally collected in a large population screening for individuals 57-77 years old performed in 1992-1997. In Study IV, 322 elderly subjects 77-89 years old were screened for glaucoma in 2019-2021. We found that the prevalence of undetected glaucoma increased with age but disease severity was similar at 60-77 years of age with about 30% of glaucomatous eyes with advanced disease or worse, but mostly early in elderly patients 77-89 years old.<br/>Using the large screening material from 1992-1997 that included 32,918 subjects, we<br/>created a regression model for the prediction of undetected glaucoma based on the<br/>combined effect of age and intraocular pressure (Study II). Glaucoma increased<br/>exponentially with age and intraocular pressure.<br/>Study III aimed to find the lifetime risk of glaucoma visual impairment in individuals<br/>followed-up for raised intraocular pressure since the 1980s. We found that only 9% of<br/>subjects developed bilateral visual impairment and 3% bilateral blindness resulting<br/>from glaucoma.<br/>The results are of value when estimating the need for improved glaucoma detection and when considering the management of patients with raised intraocular pressure.}}, author = {{Oskarsdottir, Sigridur}}, isbn = {{978-91-8021-187-1}}, issn = {{1652-8220}}, keywords = {{Glaucoma; Glaucoma stages; Ocular hypertension; Prevalence; Visual impairment; Prediction model; Lifetime risk; Undetected glaucoma; Screening}}, language = {{eng}}, number = {{2022:26}}, publisher = {{Lund University, Faculty of Medicine}}, school = {{Lund University}}, series = {{Lund University, Faculty of Medicine Doctoral Dissertation Series}}, title = {{Assessing Risks of Glaucoma}}, url = {{https://lup.lub.lu.se/search/files/113941621/Sgridur_OskarsdottirUtanManuscript.pdf}}, year = {{2022}}, }