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Coordination crosslinking of helical substituted oligoamide nanorods with Cu(II)

Buchanan, Claire ; Garvey, Christopher J. LU orcid ; Puskar, Ljiljana ; Perlmutter, Patrick and Mechler, Adam (2020) In Supramolecular Chemistry 32(3). p.222-232
Abstract

Substituted oligoamides are short sequences of unnatural amino acids. Oligoamides made entirely of β3 amino acids yield helical monomers that, if N-acylated, assemble into nanorod structures via a supramolecular assembly motif. In this work, coordination crosslinking was used to create complex nanomaterials from oligoamides WKLWEL (KE) and WELWEL (EE) (the letters denote the analogous α-amino acids). Upon Cu(II) addition, atomic force microscopy and small angle neutron scattering revealed morphologic changes specific to KE but absent in EE. Vibration spectroscopy measurements revealed that Cu(II) can coordinate to the amine moieties of the side chains, without direct effect on the backbone amides.  While coordination in... (More)

Substituted oligoamides are short sequences of unnatural amino acids. Oligoamides made entirely of β3 amino acids yield helical monomers that, if N-acylated, assemble into nanorod structures via a supramolecular assembly motif. In this work, coordination crosslinking was used to create complex nanomaterials from oligoamides WKLWEL (KE) and WELWEL (EE) (the letters denote the analogous α-amino acids). Upon Cu(II) addition, atomic force microscopy and small angle neutron scattering revealed morphologic changes specific to KE but absent in EE. Vibration spectroscopy measurements revealed that Cu(II) can coordinate to the amine moieties of the side chains, without direct effect on the backbone amides.  While coordination in excess solvent lead to regular nanostructures, fast drying of the sample yielded oligoamide templated crystallization of CuCl2. The metal coordination crosslinking of supramolecular assemblies as reported here is the first realization of a metallosupramolecular framework structure.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
14-helix, metal coordination, metallosupramolecular framework, Spontaneous assembly, substituted oligoamides
in
Supramolecular Chemistry
volume
32
issue
3
pages
11 pages
publisher
Taylor & Francis
external identifiers
  • scopus:85079711425
ISSN
1061-0278
DOI
10.1080/10610278.2020.1730839
language
English
LU publication?
yes
id
a0567b40-4a69-4453-a641-275a5d4bd4ff
date added to LUP
2020-03-05 12:09:26
date last changed
2022-11-15 22:07:22
@article{a0567b40-4a69-4453-a641-275a5d4bd4ff,
  abstract     = {{<p>Substituted oligoamides are short sequences of unnatural amino acids. Oligoamides made entirely of β<sup>3</sup> amino acids yield helical monomers that, if N-acylated, assemble into nanorod structures via a supramolecular assembly motif. In this work, coordination crosslinking was used to create complex nanomaterials from oligoamides WKLWEL (KE) and WELWEL (EE) (the letters denote the analogous α-amino acids). Upon Cu(II) addition, atomic force microscopy and small angle neutron scattering revealed morphologic changes specific to KE but absent in EE. Vibration spectroscopy measurements revealed that Cu(II) can coordinate to the amine moieties of the side chains, without direct effect on the backbone amides.  While coordination in excess solvent lead to regular nanostructures, fast drying of the sample yielded oligoamide templated crystallization of CuCl<sub>2</sub>. The metal coordination crosslinking of supramolecular assemblies as reported here is the first realization of a metallosupramolecular framework structure.</p>}},
  author       = {{Buchanan, Claire and Garvey, Christopher J. and Puskar, Ljiljana and Perlmutter, Patrick and Mechler, Adam}},
  issn         = {{1061-0278}},
  keywords     = {{14-helix; metal coordination; metallosupramolecular framework; Spontaneous assembly; substituted oligoamides}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{3}},
  pages        = {{222--232}},
  publisher    = {{Taylor & Francis}},
  series       = {{Supramolecular Chemistry}},
  title        = {{Coordination crosslinking of helical substituted oligoamide nanorods with Cu(II)}},
  url          = {{http://dx.doi.org/10.1080/10610278.2020.1730839}},
  doi          = {{10.1080/10610278.2020.1730839}},
  volume       = {{32}},
  year         = {{2020}},
}