Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease
Jakobsson, Jonas K F LU ; Aaltonen, H Laura LU ; Nicklasson, Hanna LU ; Gudmundsson, Anders LU ; Rissler, Jenny LU ; Wollmer, Per LU and Löndahl, Jakob LU
(2018)
In BMC Pulmonary Medicine
18(1).
- Abstract
BACKGROUND: Respiratory tract deposition of airborne particles is a key link to understand their health impact. Experimental data are limited for vulnerable groups such as individuals with respiratory diseases. The aim of this study is to investigate the differences in lung deposition of nanoparticles in the distal lung for healthy subjects and subjects with respiratory disease.
METHODS: Lung deposition of nanoparticles (50 and 100 nm) was measured after a 10 s breath-hold for three groups: healthy never-smoking subjects (n = 17), asymptomatic (active and former) smokers (n = 15) and subjects with chronic obstructive pulmonary disease (n = 16). Measurements were made at 1300 mL and 1800 mL volumetric lung depth. Each subject also... (More)
BACKGROUND: Respiratory tract deposition of airborne particles is a key link to understand their health impact. Experimental data are limited for vulnerable groups such as individuals with respiratory diseases. The aim of this study is to investigate the differences in lung deposition of nanoparticles in the distal lung for healthy subjects and subjects with respiratory disease.
METHODS: Lung deposition of nanoparticles (50 and 100 nm) was measured after a 10 s breath-hold for three groups: healthy never-smoking subjects (n = 17), asymptomatic (active and former) smokers (n = 15) and subjects with chronic obstructive pulmonary disease (n = 16). Measurements were made at 1300 mL and 1800 mL volumetric lung depth. Each subject also underwent conventional lung function tests, including post bronchodilator FEV1, VC, and diffusing capacity for carbon monoxide, DL,CO. Patients with previously diagnosed respiratory disease underwent a CT-scan of the lungs. Particle lung deposition fraction, was compared between the groups and with conventional lung function tests.
RESULTS: We found that the deposition fraction was significantly lower for subjects with emphysema compared to the other subjects (p = 0.001-0.01), but no significant differences were found between healthy never-smokers and smokers. Furthermore, the particle deposition correlated with pulmonary function tests, FEV1%Pred (p < 0.05), FEV1/VC%Pred (p < 0.01) and DL,CO (p < 0.0005) when all subjects were included. Furthermore, for subjects with emphysema, deposition fraction correlated strongly with DL,CO (Pearson's r = 0.80-0.85, p < 0.002) while this correlation was not found within the other groups.
CONCLUSIONS: Lower deposition fraction was observed for emphysematous subjects and this can be explained by enlarged distal airspaces in the lungs. As expected, deposition increases for smaller particles and deeper inhalation. The observed results have implications for exposure assessment of air pollution and dosimetry of aerosol-based drug delivery of nanoparticles.
(Less)
- author
- Jakobsson, Jonas K F
LU
; Aaltonen, H Laura
LU
; Nicklasson, Hanna
LU
; Gudmundsson, Anders
LU
; Rissler, Jenny
LU
; Wollmer, Per
LU
and Löndahl, Jakob
LU
- organization
- publishing date
- 2018-08-06
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Pulmonary Medicine
- volume
- 18
- issue
- 1
- article number
- 129
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85054930344
- pmid:30081885
- ISSN
- 1471-2466
- DOI
- 10.1186/s12890-018-0697-2
- language
- English
- LU publication?
- yes
- id
- a0ca3f01-a191-4f7d-bfa8-763a892d35cf
- date added to LUP
- 2018-09-24 14:50:49
- date last changed
- 2024-03-02 00:48:19
@article{a0ca3f01-a191-4f7d-bfa8-763a892d35cf,
abstract = {{<p>BACKGROUND: Respiratory tract deposition of airborne particles is a key link to understand their health impact. Experimental data are limited for vulnerable groups such as individuals with respiratory diseases. The aim of this study is to investigate the differences in lung deposition of nanoparticles in the distal lung for healthy subjects and subjects with respiratory disease.</p><p>METHODS: Lung deposition of nanoparticles (50 and 100 nm) was measured after a 10 s breath-hold for three groups: healthy never-smoking subjects (n = 17), asymptomatic (active and former) smokers (n = 15) and subjects with chronic obstructive pulmonary disease (n = 16). Measurements were made at 1300 mL and 1800 mL volumetric lung depth. Each subject also underwent conventional lung function tests, including post bronchodilator FEV1, VC, and diffusing capacity for carbon monoxide, DL,CO. Patients with previously diagnosed respiratory disease underwent a CT-scan of the lungs. Particle lung deposition fraction, was compared between the groups and with conventional lung function tests.</p><p>RESULTS: We found that the deposition fraction was significantly lower for subjects with emphysema compared to the other subjects (p = 0.001-0.01), but no significant differences were found between healthy never-smokers and smokers. Furthermore, the particle deposition correlated with pulmonary function tests, FEV1%Pred (p < 0.05), FEV1/VC%Pred (p < 0.01) and DL,CO (p < 0.0005) when all subjects were included. Furthermore, for subjects with emphysema, deposition fraction correlated strongly with DL,CO (Pearson's r = 0.80-0.85, p < 0.002) while this correlation was not found within the other groups.</p><p>CONCLUSIONS: Lower deposition fraction was observed for emphysematous subjects and this can be explained by enlarged distal airspaces in the lungs. As expected, deposition increases for smaller particles and deeper inhalation. The observed results have implications for exposure assessment of air pollution and dosimetry of aerosol-based drug delivery of nanoparticles.</p>}},
author = {{Jakobsson, Jonas K F and Aaltonen, H Laura and Nicklasson, Hanna and Gudmundsson, Anders and Rissler, Jenny and Wollmer, Per and Löndahl, Jakob}},
issn = {{1471-2466}},
language = {{eng}},
month = {{08}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Pulmonary Medicine}},
title = {{Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease}},
url = {{http://dx.doi.org/10.1186/s12890-018-0697-2}},
doi = {{10.1186/s12890-018-0697-2}},
volume = {{18}},
year = {{2018}},
}