Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant
(2019) In Natural Product Communications 14(1). p.55-58- Abstract
A bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.
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https://lup.lub.lu.se/record/a155d1fe-5c8b-4782-b5be-c4a85923fb44
- author
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bolivia, Cytotoxicity, Giardia lamblia, Hyptis brevipes, Leishmania spp, Plasmodium falciparum, Tacana, Trypanosoma cruzi
- in
- Natural Product Communications
- volume
- 14
- issue
- 1
- pages
- 4 pages
- publisher
- Natural Products Inc
- external identifiers
-
- scopus:85063748149
- ISSN
- 1934-578X
- DOI
- 10.1177/1934578X1901400115
- language
- English
- LU publication?
- yes
- id
- a155d1fe-5c8b-4782-b5be-c4a85923fb44
- date added to LUP
- 2019-04-23 13:57:00
- date last changed
- 2022-06-13 18:02:30
@article{a155d1fe-5c8b-4782-b5be-c4a85923fb44, abstract = {{<p>A bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.</p>}}, author = {{Limachi, Ivan and Condo, Claudia and Palma, Camila and Nina, Nelida and Salamanca, Efrain and Ticona, Juan C. and Udaeta, Enrique and Flores, Ninoska and Serato, Alcides and Marupa, Natalio and Chao, Benigno and Ibaguari, Gladys and Nay, Constantino and Manner, Soffie and Sterner, Olov and Giménez, Alberto}}, issn = {{1934-578X}}, keywords = {{Bolivia; Cytotoxicity; Giardia lamblia; Hyptis brevipes; Leishmania spp; Plasmodium falciparum; Tacana; Trypanosoma cruzi}}, language = {{eng}}, number = {{1}}, pages = {{55--58}}, publisher = {{Natural Products Inc}}, series = {{Natural Product Communications}}, title = {{Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant}}, url = {{http://dx.doi.org/10.1177/1934578X1901400115}}, doi = {{10.1177/1934578X1901400115}}, volume = {{14}}, year = {{2019}}, }