First European Case of Simultaneous Liver and Pancreas Transplantation as Treatment of Wolcott-Rallison Syndrome in a Small Child
(2020) In Transplantation 104(3). p.522-525- Abstract
BACKGROUND: The concept of organ transplantation as treatment for complex genetic conditions, including Wolcott-Rallison syndrome (WRS), continues to show promise. Liver transplantation is essential for survival of patients with WRS, and pancreas transplantation cures their type I diabetes mellitus. METHODS: The recipient, a 3-year-old girl weighing 14 kg at the time of transplantation, suffered from major complications of WRS, including repetitive liver failure episodes and poorly controlled diabetes. The patient underwent a nonacute, combined, simultaneous liver and pancreas transplantation from a pediatric donor without using the en bloc technique. RESULTS: Well-preserved graft functions at 2-year follow-up with normal liver and... (More)
BACKGROUND: The concept of organ transplantation as treatment for complex genetic conditions, including Wolcott-Rallison syndrome (WRS), continues to show promise. Liver transplantation is essential for survival of patients with WRS, and pancreas transplantation cures their type I diabetes mellitus. METHODS: The recipient, a 3-year-old girl weighing 14 kg at the time of transplantation, suffered from major complications of WRS, including repetitive liver failure episodes and poorly controlled diabetes. The patient underwent a nonacute, combined, simultaneous liver and pancreas transplantation from a pediatric donor without using the en bloc technique. RESULTS: Well-preserved graft functions at 2-year follow-up with normal liver and pancreas function. CONCLUSIONS: This is the first case report of simultaneous liver and pancreas transplantation as treatment of WRS in a small child in Europe. Two-year follow-up demonstrates that organ transplantation can halt life-threating recurrent liver failure episodes and cure type 1 diabetes.
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- author
- Nordström, Johan ; Lundgren, Markus LU ; Jorns, Carl ; Fischler, Björn ; Arnell, Henrik ; Dlugosz, Rafal ; Sandberg, John ; Wennberg, Lars and Nowak, Greg
- organization
- publishing date
- 2020-03
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Transplantation
- volume
- 104
- issue
- 3
- pages
- 4 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:31335762
- scopus:85080837034
- ISSN
- 1534-6080
- DOI
- 10.1097/TP.0000000000002869
- language
- English
- LU publication?
- yes
- id
- a1781161-6cdd-4450-a71c-867d49e63124
- date added to LUP
- 2020-03-18 10:17:39
- date last changed
- 2024-10-02 23:35:37
@article{a1781161-6cdd-4450-a71c-867d49e63124, abstract = {{<p>BACKGROUND: The concept of organ transplantation as treatment for complex genetic conditions, including Wolcott-Rallison syndrome (WRS), continues to show promise. Liver transplantation is essential for survival of patients with WRS, and pancreas transplantation cures their type I diabetes mellitus. METHODS: The recipient, a 3-year-old girl weighing 14 kg at the time of transplantation, suffered from major complications of WRS, including repetitive liver failure episodes and poorly controlled diabetes. The patient underwent a nonacute, combined, simultaneous liver and pancreas transplantation from a pediatric donor without using the en bloc technique. RESULTS: Well-preserved graft functions at 2-year follow-up with normal liver and pancreas function. CONCLUSIONS: This is the first case report of simultaneous liver and pancreas transplantation as treatment of WRS in a small child in Europe. Two-year follow-up demonstrates that organ transplantation can halt life-threating recurrent liver failure episodes and cure type 1 diabetes.</p>}}, author = {{Nordström, Johan and Lundgren, Markus and Jorns, Carl and Fischler, Björn and Arnell, Henrik and Dlugosz, Rafal and Sandberg, John and Wennberg, Lars and Nowak, Greg}}, issn = {{1534-6080}}, language = {{eng}}, number = {{3}}, pages = {{522--525}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Transplantation}}, title = {{First European Case of Simultaneous Liver and Pancreas Transplantation as Treatment of Wolcott-Rallison Syndrome in a Small Child}}, url = {{http://dx.doi.org/10.1097/TP.0000000000002869}}, doi = {{10.1097/TP.0000000000002869}}, volume = {{104}}, year = {{2020}}, }