Olika tillstånd av pulmonell hypertension ska inte förväxlas : PAH-läkemedel bör inte användas vid pulmonell hypertension på basen av vänstersidig hjärtsjukdom
(2019) In Läkartidningen 116(13).- Abstract
Pulmonary hypertension is a common consequence of left heart disease, associated with poor prognosis. The pulmonary hypertension in left heart disease is initially caused by a passive congestion of the pulmonary circuit but may, if longstanding, result in endothelial dysfunction and excessive vasoconstriction. In some cases pulmonary vascular remodeling occur, further complicating the condition and worsening the prognosis. It has been debated whether these patients may benefit from pulmonary vasodilators presently used in pulmonary arterial hypertension. Several randomized controlled trials have been performed on this subject, the vast majority being negative. As maintenance therapy may be harmful, they should be avoided outside... (More)
Pulmonary hypertension is a common consequence of left heart disease, associated with poor prognosis. The pulmonary hypertension in left heart disease is initially caused by a passive congestion of the pulmonary circuit but may, if longstanding, result in endothelial dysfunction and excessive vasoconstriction. In some cases pulmonary vascular remodeling occur, further complicating the condition and worsening the prognosis. It has been debated whether these patients may benefit from pulmonary vasodilators presently used in pulmonary arterial hypertension. Several randomized controlled trials have been performed on this subject, the vast majority being negative. As maintenance therapy may be harmful, they should be avoided outside clinical trials.
(Less)
- author
- Lundgren, Jakob LU and Rådegran, Göran LU
- organization
- alternative title
- Pulmonary hypertension due to left heart disease - not to be confused with pulmonary arterial hypertension
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Läkartidningen
- volume
- 116
- issue
- 13
- pages
- 3 pages
- publisher
- Swedish Medical Association
- external identifiers
-
- scopus:85064493367
- ISSN
- 0023-7205
- language
- Swedish
- LU publication?
- yes
- id
- a2d8eafa-a718-42c2-a787-0c46714ecad6
- alternative location
- http://www.lakartidningen.se/Klinik-och-vetenskap/Kommentar/2019/03/Olika-tillstand-av-pulmonell-hypertension-ska-inte-forvaxlas/
- date added to LUP
- 2019-05-06 13:45:40
- date last changed
- 2022-04-25 23:23:05
@article{a2d8eafa-a718-42c2-a787-0c46714ecad6, abstract = {{<p>Pulmonary hypertension is a common consequence of left heart disease, associated with poor prognosis. The pulmonary hypertension in left heart disease is initially caused by a passive congestion of the pulmonary circuit but may, if longstanding, result in endothelial dysfunction and excessive vasoconstriction. In some cases pulmonary vascular remodeling occur, further complicating the condition and worsening the prognosis. It has been debated whether these patients may benefit from pulmonary vasodilators presently used in pulmonary arterial hypertension. Several randomized controlled trials have been performed on this subject, the vast majority being negative. As maintenance therapy may be harmful, they should be avoided outside clinical trials.</p>}}, author = {{Lundgren, Jakob and Rådegran, Göran}}, issn = {{0023-7205}}, language = {{swe}}, number = {{13}}, publisher = {{Swedish Medical Association}}, series = {{Läkartidningen}}, title = {{Olika tillstånd av pulmonell hypertension ska inte förväxlas : PAH-läkemedel bör inte användas vid pulmonell hypertension på basen av vänstersidig hjärtsjukdom}}, url = {{http://www.lakartidningen.se/Klinik-och-vetenskap/Kommentar/2019/03/Olika-tillstand-av-pulmonell-hypertension-ska-inte-forvaxlas/}}, volume = {{116}}, year = {{2019}}, }