Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Age at first childbirth and breast cancer survival : A prospective cohort study

Aurin, Johanna LU ; Thorlacius, Henrik LU and Butt, Salma Tunå LU (2020) In BMC Research Notes 13(1).
Abstract

Objective: Late age at first childbirth is a well-established risk factor for breast cancer. Previous studies have, however, shown conflicting results to whether late age at first childbirth also influences the prognosis of breast cancer survival. The aim of this study was to examine age at first birth in relation to survival after breast cancer diagnosis. Results: We used information from the Malmö Diet and Cancer study. At baseline 17,035 women were included. All women were followed from the year they developed breast cancer until they either died or until the end of follow-up. All women were asked how many children they had given birth to and were then divided into different groups, ≤ 20, > 20 to ≤ 25, > 25 to ≤ 30 and > 30.... (More)

Objective: Late age at first childbirth is a well-established risk factor for breast cancer. Previous studies have, however, shown conflicting results to whether late age at first childbirth also influences the prognosis of breast cancer survival. The aim of this study was to examine age at first birth in relation to survival after breast cancer diagnosis. Results: We used information from the Malmö Diet and Cancer study. At baseline 17,035 women were included. All women were followed from the year they developed breast cancer until they either died or until the end of follow-up. All women were asked how many children they had given birth to and were then divided into different groups, ≤ 20, > 20 to ≤ 25, > 25 to ≤ 30 and > 30. Nulliparous women form a separate group. Survival analyses were then performed using Cox proportional hazard survival analysis. Women in all age groups had a lower risk of breast cancer specific death as compared to the reference group ≤ 20, however non-significantly. Nulliparous women had a higher risk of breast cancer specific death as compared to the same reference group, however these results were not statistically significant. We could not see any negative effect of late first childbirth on breast cancer specific survival.

(Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Age at first childbirth, Breast cancer risk, Nulliparity, Reproductive factors, Survival
in
BMC Research Notes
volume
13
issue
1
article number
9
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85077523748
  • pmid:31907014
ISSN
1756-0500
DOI
10.1186/s13104-019-4864-1
language
English
LU publication?
yes
id
a411dd1a-c97e-4d8e-9ac3-89d433927e94
date added to LUP
2020-01-28 08:31:20
date last changed
2024-04-03 01:35:34
@article{a411dd1a-c97e-4d8e-9ac3-89d433927e94,
  abstract     = {{<p>Objective: Late age at first childbirth is a well-established risk factor for breast cancer. Previous studies have, however, shown conflicting results to whether late age at first childbirth also influences the prognosis of breast cancer survival. The aim of this study was to examine age at first birth in relation to survival after breast cancer diagnosis. Results: We used information from the Malmö Diet and Cancer study. At baseline 17,035 women were included. All women were followed from the year they developed breast cancer until they either died or until the end of follow-up. All women were asked how many children they had given birth to and were then divided into different groups, ≤ 20, &gt; 20 to ≤ 25, &gt; 25 to ≤ 30 and &gt; 30. Nulliparous women form a separate group. Survival analyses were then performed using Cox proportional hazard survival analysis. Women in all age groups had a lower risk of breast cancer specific death as compared to the reference group ≤ 20, however non-significantly. Nulliparous women had a higher risk of breast cancer specific death as compared to the same reference group, however these results were not statistically significant. We could not see any negative effect of late first childbirth on breast cancer specific survival.</p>}},
  author       = {{Aurin, Johanna and Thorlacius, Henrik and Butt, Salma Tunå}},
  issn         = {{1756-0500}},
  keywords     = {{Age at first childbirth; Breast cancer risk; Nulliparity; Reproductive factors; Survival}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Research Notes}},
  title        = {{Age at first childbirth and breast cancer survival : A prospective cohort study}},
  url          = {{http://dx.doi.org/10.1186/s13104-019-4864-1}},
  doi          = {{10.1186/s13104-019-4864-1}},
  volume       = {{13}},
  year         = {{2020}},
}