Bacterial Adherence and Epithelial Cell Cytokine Production
(1993) In Zentralblatt fur Bakteriologie 278(2-3). p.359-364- Abstract
Epithelial cell lines produce the cytokines IL-1α, IL-6 and IL-8 when stimulated with Escherichia coli. The cytokine response is enhanced by P fimbriae. The epithelial cell lines also respond to stimulation with other cytokines. These in vitro findings were confirmed in vivo in patients with E. coli infection who secreted IL-6 and IL-8 into the urine. The observations suggest that epithelial cells play a more active role in the mucosal immune response than previously recognized.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/a4b6c697-880c-4371-8ea2-b101bba26484
- author
- Svanborg, Catharina LU ; Agace, William LU ; Hedges, Spencer ; Linder, Henrik and Svensson, Majlis LU
- organization
- publishing date
- 1993-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Zentralblatt fur Bakteriologie
- volume
- 278
- issue
- 2-3
- pages
- 6 pages
- publisher
- Fischer
- external identifiers
-
- scopus:0027582287
- pmid:8347939
- ISSN
- 0934-8840
- DOI
- 10.1016/S0934-8840(11)80852-2
- language
- English
- LU publication?
- yes
- id
- a4b6c697-880c-4371-8ea2-b101bba26484
- date added to LUP
- 2019-05-30 14:00:19
- date last changed
- 2024-01-01 08:33:36
@article{a4b6c697-880c-4371-8ea2-b101bba26484, abstract = {{<p>Epithelial cell lines produce the cytokines IL-1α, IL-6 and IL-8 when stimulated with Escherichia coli. The cytokine response is enhanced by P fimbriae. The epithelial cell lines also respond to stimulation with other cytokines. These in vitro findings were confirmed in vivo in patients with E. coli infection who secreted IL-6 and IL-8 into the urine. The observations suggest that epithelial cells play a more active role in the mucosal immune response than previously recognized.</p>}}, author = {{Svanborg, Catharina and Agace, William and Hedges, Spencer and Linder, Henrik and Svensson, Majlis}}, issn = {{0934-8840}}, language = {{eng}}, month = {{01}}, number = {{2-3}}, pages = {{359--364}}, publisher = {{Fischer}}, series = {{Zentralblatt fur Bakteriologie}}, title = {{Bacterial Adherence and Epithelial Cell Cytokine Production}}, url = {{http://dx.doi.org/10.1016/S0934-8840(11)80852-2}}, doi = {{10.1016/S0934-8840(11)80852-2}}, volume = {{278}}, year = {{1993}}, }