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Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women : A population-based follow-up study

Memon, Ashfaque A LU orcid ; Sundquist, Jan LU ; Hedelius, Anna LU ; Palmér, Karolina LU ; Wang, Xiao LU and Sundquist, Kristina LU (2021) In Scientific Reports 11.
Abstract

Mitochondrial dysfunction is an important factor of the aging process and may play a key role in various diseases. Mitochondrial DNA copy number (mtDNA-CN) is an indirect measure of mitochondrial dysfunction and is associated with type 2 diabetes mellitus (T2DM); however, whether mtDNA-CN can predict the risk of developing T2DM is not well-known. We quantified absolute mtDNA-CN in both prevalent and incident T2DM by well-optimized droplet digital PCR (ddPCR) method in a population-based follow-up study of middle aged (50-59 years) Swedish women (n = 2387). The median follow-up period was 17 years. Compared to those who were free of T2DM, mtDNA-CN was significantly lower in both prevalent T2DM and in women who developed T2DM during the... (More)

Mitochondrial dysfunction is an important factor of the aging process and may play a key role in various diseases. Mitochondrial DNA copy number (mtDNA-CN) is an indirect measure of mitochondrial dysfunction and is associated with type 2 diabetes mellitus (T2DM); however, whether mtDNA-CN can predict the risk of developing T2DM is not well-known. We quantified absolute mtDNA-CN in both prevalent and incident T2DM by well-optimized droplet digital PCR (ddPCR) method in a population-based follow-up study of middle aged (50-59 years) Swedish women (n = 2387). The median follow-up period was 17 years. Compared to those who were free of T2DM, mtDNA-CN was significantly lower in both prevalent T2DM and in women who developed T2DM during the follow-up period. Mitochondrial DNA-copy number was also associated with glucose intolerance, systolic blood pressure, smoking status and education. In multivariable Cox regression analysis, lower baseline mtDNA-CN was prospectively associated with a higher risk of T2DM, independent of age, BMI, education, smoking status and physical activity. Moreover, interaction term analysis showed that smoking increased the effect of low mtDNA-CN at baseline on the risk of incident T2DM. Mitochondrial DNA-copy number may be a risk factor of T2DM in women. The clinical usefulness of mtDNA-CN to predict the future risk of T2DM warrants further investigation.

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author
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organization
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type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
11
article number
4608
publisher
Nature Publishing Group
external identifiers
  • scopus:85101757761
  • pmid:33633270
ISSN
2045-2322
DOI
10.1038/s41598-021-84132-w
language
English
LU publication?
yes
id
a7db9b1a-9b29-4ace-a127-edf60b7cd7c9
date added to LUP
2021-03-04 22:17:30
date last changed
2024-08-22 14:51:22
@article{a7db9b1a-9b29-4ace-a127-edf60b7cd7c9,
  abstract     = {{<p>Mitochondrial dysfunction is an important factor of the aging process and may play a key role in various diseases. Mitochondrial DNA copy number (mtDNA-CN) is an indirect measure of mitochondrial dysfunction and is associated with type 2 diabetes mellitus (T2DM); however, whether mtDNA-CN can predict the risk of developing T2DM is not well-known. We quantified absolute mtDNA-CN in both prevalent and incident T2DM by well-optimized droplet digital PCR (ddPCR) method in a population-based follow-up study of middle aged (50-59 years) Swedish women (n = 2387). The median follow-up period was 17 years. Compared to those who were free of T2DM, mtDNA-CN was significantly lower in both prevalent T2DM and in women who developed T2DM during the follow-up period. Mitochondrial DNA-copy number was also associated with glucose intolerance, systolic blood pressure, smoking status and education. In multivariable Cox regression analysis, lower baseline mtDNA-CN was prospectively associated with a higher risk of T2DM, independent of age, BMI, education, smoking status and physical activity. Moreover, interaction term analysis showed that smoking increased the effect of low mtDNA-CN at baseline on the risk of incident T2DM. Mitochondrial DNA-copy number may be a risk factor of T2DM in women. The clinical usefulness of mtDNA-CN to predict the future risk of T2DM warrants further investigation.</p>}},
  author       = {{Memon, Ashfaque A and Sundquist, Jan and Hedelius, Anna and Palmér, Karolina and Wang, Xiao and Sundquist, Kristina}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women : A population-based follow-up study}},
  url          = {{http://dx.doi.org/10.1038/s41598-021-84132-w}},
  doi          = {{10.1038/s41598-021-84132-w}},
  volume       = {{11}},
  year         = {{2021}},
}