Outcome after acute ischemic stroke is linked to sex-specific lesion patterns
(2021) In Nature Communications 12(1).- Abstract
- Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). This framework was developed in 555 patients (38% female). Findings were validated in an independent cohort (n = 503, 41% female). Here, we show brain lesions in regions subserving motor and language functions help explain stroke severity in both men and women, however more widespread lesion patterns are relevant in female... (More)
- Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). This framework was developed in 555 patients (38% female). Findings were validated in an independent cohort (n = 503, 41% female). Here, we show brain lesions in regions subserving motor and language functions help explain stroke severity in both men and women, however more widespread lesion patterns are relevant in female patients. Higher stroke severity in women, but not men, is associated with left hemisphere lesions in the vicinity of the posterior circulation. Our results suggest there are sex-specific functional cerebral asymmetries that may be important for future investigations of sex-stratified approaches to management of acute ischemic stroke. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/aba63928-44d6-4bb6-9bb9-7ea74c43c1ab
- author
- Bonkhoff, A.K. ; Söderholm, Martin LU ; Wasselius, Johan LU ; Lindgren, Arne LU and Rost, Natalia S.
- author collaboration
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- aged, Bayes theorem, brain ischemia, brain mapping, brain stem, cerebral revascularization, cohort analysis, diagnostic imaging, female, human, image processing, male, middle aged, nuclear magnetic resonance imaging, pathology, procedures, risk factor, sensorimotor cortex, severity of illness index, sex factor, thalamus, treatment outcome, vascularization, very elderly, Aged, Aged, 80 and over, Bayes Theorem, Brain Mapping, Brain Stem, Cerebral Revascularization, Cohort Studies, Female, Humans, Image Processing, Computer-Assisted, Ischemic Stroke, Magnetic Resonance Imaging, Male, Middle Aged, Risk Factors, Sensorimotor Cortex, Severity of Illness Index, Sex Factors, Thalamus, Treatment Outcome
- in
- Nature Communications
- volume
- 12
- issue
- 1
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85108133400
- pmid:34078897
- ISSN
- 2041-1723
- DOI
- 10.1038/s41467-021-23492-3
- language
- English
- LU publication?
- yes
- id
- aba63928-44d6-4bb6-9bb9-7ea74c43c1ab
- date added to LUP
- 2021-09-13 13:49:13
- date last changed
- 2022-04-27 03:53:22
@article{aba63928-44d6-4bb6-9bb9-7ea74c43c1ab,
abstract = {{Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). This framework was developed in 555 patients (38% female). Findings were validated in an independent cohort (n = 503, 41% female). Here, we show brain lesions in regions subserving motor and language functions help explain stroke severity in both men and women, however more widespread lesion patterns are relevant in female patients. Higher stroke severity in women, but not men, is associated with left hemisphere lesions in the vicinity of the posterior circulation. Our results suggest there are sex-specific functional cerebral asymmetries that may be important for future investigations of sex-stratified approaches to management of acute ischemic stroke.}},
author = {{Bonkhoff, A.K. and Söderholm, Martin and Wasselius, Johan and Lindgren, Arne and Rost, Natalia S.}},
issn = {{2041-1723}},
keywords = {{aged; Bayes theorem; brain ischemia; brain mapping; brain stem; cerebral revascularization; cohort analysis; diagnostic imaging; female; human; image processing; male; middle aged; nuclear magnetic resonance imaging; pathology; procedures; risk factor; sensorimotor cortex; severity of illness index; sex factor; thalamus; treatment outcome; vascularization; very elderly; Aged; Aged, 80 and over; Bayes Theorem; Brain Mapping; Brain Stem; Cerebral Revascularization; Cohort Studies; Female; Humans; Image Processing, Computer-Assisted; Ischemic Stroke; Magnetic Resonance Imaging; Male; Middle Aged; Risk Factors; Sensorimotor Cortex; Severity of Illness Index; Sex Factors; Thalamus; Treatment Outcome}},
language = {{eng}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{Nature Communications}},
title = {{Outcome after acute ischemic stroke is linked to sex-specific lesion patterns}},
url = {{http://dx.doi.org/10.1038/s41467-021-23492-3}},
doi = {{10.1038/s41467-021-23492-3}},
volume = {{12}},
year = {{2021}},
}