Aetiology of acute/subacute nephritic syndrome : results from kidney biopsy registries in Japan and Europe
(2025) In BMC Nephrology 26(1).- Abstract
Background: The combination of hematuria, proteinuria and a reduced glomerular filtration rate (GFR) in patients with no previous diagnosis of chronic kidney disease is widely considered a strong indication for kidney biopsy. This study aimed to compare the frequencies of diseases leading to this symptom constellation, and to explore differences related to age and sex using data from kidney biopsy registries in Europe and Japan. Methods: Data were retrieved from national or regional kidney biopsy registries in Japan, Sweden, Norway, Scotland, Austria, Croatia and Turkey from January 1, 2007, to December 31, 2019. Patients were included if the indication for kidney biopsy was acute/subacute nephritic syndrome, which was defined as a... (More)
Background: The combination of hematuria, proteinuria and a reduced glomerular filtration rate (GFR) in patients with no previous diagnosis of chronic kidney disease is widely considered a strong indication for kidney biopsy. This study aimed to compare the frequencies of diseases leading to this symptom constellation, and to explore differences related to age and sex using data from kidney biopsy registries in Europe and Japan. Methods: Data were retrieved from national or regional kidney biopsy registries in Japan, Sweden, Norway, Scotland, Austria, Croatia and Turkey from January 1, 2007, to December 31, 2019. Patients were included if the indication for kidney biopsy was acute/subacute nephritic syndrome, which was defined as a combination of hematuria, proteinuria and reduced GFR in a patient without a prior diagnosis of chronic kidney disease. Demographic, clinical and laboratory data were collected at the time of kidney biopsy. Results: A total of 1023 patients from Europe and 2477 from Japan were included in the study. The primary cause of acute/subacute nephritic syndrome in both regions was ANCA-associated vasculitis, followed by IgA nephropathy/vasculitis and acute interstitial nephritis. The estimated GFR was higher in Europe than in Japan, at 24 and 20 ml/min/1,73 m2, respectively. The median age was 10 years younger in European patients than in Japanese patients. Conclusions: The most common underlying causes of acute/subacute nephritic syndrome are ANCA-associated vasculitis, IgA nephropathy/vasculitis and acute interstitial nephritis. This study highlights both similarities and differences in the spectrum of underlying diagnoses and clinical presentations across ages, sexes, and geographical regions in patients presenting with acute/subacute nephritic syndrome.
(Less)
- author
- Weiner, Maria
; Sugiyama, Hitoshi
; Kaname, Shinya
; Skrunes, Rannveig
; Prenner, Anna
; Crnogorac, Matija
; Geddes, Colin
; Türkmen, Kültigin
; Galesic, Kresimir
; Rosenkranz, Alexander R.
; Suzuki, Yusuke
; Fujimoto, Shouichi
and Segelmark, Mårten
LU
(Less) - organization
- publishing date
- 2025-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acute interstitial nephritis, Acute nephritic syndrome, ANCA-associated vasculitis, Geographical region, IgA nephropathy, Kidney biopsy
- in
- BMC Nephrology
- volume
- 26
- issue
- 1
- article number
- 625
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:105021048871
- pmid:41199173
- ISSN
- 1471-2369
- DOI
- 10.1186/s12882-025-04582-6
- language
- English
- LU publication?
- yes
- id
- abdd7f5b-ba67-4266-aa0c-6738981c2e99
- date added to LUP
- 2025-12-09 13:04:09
- date last changed
- 2025-12-09 13:04:26
@article{abdd7f5b-ba67-4266-aa0c-6738981c2e99,
abstract = {{<p>Background: The combination of hematuria, proteinuria and a reduced glomerular filtration rate (GFR) in patients with no previous diagnosis of chronic kidney disease is widely considered a strong indication for kidney biopsy. This study aimed to compare the frequencies of diseases leading to this symptom constellation, and to explore differences related to age and sex using data from kidney biopsy registries in Europe and Japan. Methods: Data were retrieved from national or regional kidney biopsy registries in Japan, Sweden, Norway, Scotland, Austria, Croatia and Turkey from January 1, 2007, to December 31, 2019. Patients were included if the indication for kidney biopsy was acute/subacute nephritic syndrome, which was defined as a combination of hematuria, proteinuria and reduced GFR in a patient without a prior diagnosis of chronic kidney disease. Demographic, clinical and laboratory data were collected at the time of kidney biopsy. Results: A total of 1023 patients from Europe and 2477 from Japan were included in the study. The primary cause of acute/subacute nephritic syndrome in both regions was ANCA-associated vasculitis, followed by IgA nephropathy/vasculitis and acute interstitial nephritis. The estimated GFR was higher in Europe than in Japan, at 24 and 20 ml/min/1,73 m2, respectively. The median age was 10 years younger in European patients than in Japanese patients. Conclusions: The most common underlying causes of acute/subacute nephritic syndrome are ANCA-associated vasculitis, IgA nephropathy/vasculitis and acute interstitial nephritis. This study highlights both similarities and differences in the spectrum of underlying diagnoses and clinical presentations across ages, sexes, and geographical regions in patients presenting with acute/subacute nephritic syndrome.</p>}},
author = {{Weiner, Maria and Sugiyama, Hitoshi and Kaname, Shinya and Skrunes, Rannveig and Prenner, Anna and Crnogorac, Matija and Geddes, Colin and Türkmen, Kültigin and Galesic, Kresimir and Rosenkranz, Alexander R. and Suzuki, Yusuke and Fujimoto, Shouichi and Segelmark, Mårten}},
issn = {{1471-2369}},
keywords = {{Acute interstitial nephritis; Acute nephritic syndrome; ANCA-associated vasculitis; Geographical region; IgA nephropathy; Kidney biopsy}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Nephrology}},
title = {{Aetiology of acute/subacute nephritic syndrome : results from kidney biopsy registries in Japan and Europe}},
url = {{http://dx.doi.org/10.1186/s12882-025-04582-6}},
doi = {{10.1186/s12882-025-04582-6}},
volume = {{26}},
year = {{2025}},
}