High expression of stromal PDGFRβ is associated with reduced benefit of tamoxifen in breast cancer
(2017) In The Journal of Pathology: Clinical Research 3(1). p.38-43- Abstract
- Cancer-associated fibroblasts (CAFs) regulate tumour growth, metastasis and response to treatment. Recent studies indicate the existence of functionally distinct CAF subsets. Suggested mechanisms whereby CAFs can impact on treatment response include paracrine signaling affecting cancer cell drug sensitivity and effects on tumour drug uptake. PDGFRβ is an important regulator of fibroblasts. Experimental studies have linked PDGFRβ-positive fibroblasts to metastasis and also to reduced tumour drug uptake. This study has investigated the potential role of PDGFRβ-positive fibroblasts in response to adjuvant tamoxifen treatment of breast cancer. Analyses of two breast cancer collections from randomized studies analyzing adjuvant tamoxifen... (More)
- Cancer-associated fibroblasts (CAFs) regulate tumour growth, metastasis and response to treatment. Recent studies indicate the existence of functionally distinct CAF subsets. Suggested mechanisms whereby CAFs can impact on treatment response include paracrine signaling affecting cancer cell drug sensitivity and effects on tumour drug uptake. PDGFRβ is an important regulator of fibroblasts. Experimental studies have linked PDGFRβ-positive fibroblasts to metastasis and also to reduced tumour drug uptake. This study has investigated the potential role of PDGFRβ-positive fibroblasts in response to adjuvant tamoxifen treatment of breast cancer. Analyses of two breast cancer collections from randomized studies analyzing adjuvant tamoxifen treatment in early breast cancer demonstrated significant benefit of tamoxifen in the group with low stromal PDGFRβ, which was not observed in the group with high stromal PDGFRβ. In general terms these findings provide novel evidence, derived from analyses of randomized clinical studies, of response-predictive capacity of a marker-defined subset of CAFs and, more specifically, identify stromal PDGFRβ as a marker related to tamoxifen benefit in early breast cancer. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/af39ca00-7aea-45c2-a685-3b1a0913f2a7
- author
- Paulsson, J. ; Rydén, Lisa LU ; Strell, C ; Frings, O ; Tobin, Nicholas P LU ; Fornander, T. ; Bergh, J. ; Landberg, Göran LU ; Ståhl, O. and Östman, A.
- organization
- publishing date
- 2017-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of Pathology: Clinical Research
- volume
- 3
- issue
- 1
- pages
- 38 - 43
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:28138400
- wos:000410844100004
- scopus:85056746542
- ISSN
- 2056-4538
- DOI
- 10.1002/cjp2.56
- project
- Breast Cancer Surgery
- language
- English
- LU publication?
- yes
- id
- af39ca00-7aea-45c2-a685-3b1a0913f2a7
- date added to LUP
- 2016-11-29 11:48:57
- date last changed
- 2024-02-19 11:47:34
@article{af39ca00-7aea-45c2-a685-3b1a0913f2a7, abstract = {{Cancer-associated fibroblasts (CAFs) regulate tumour growth, metastasis and response to treatment. Recent studies indicate the existence of functionally distinct CAF subsets. Suggested mechanisms whereby CAFs can impact on treatment response include paracrine signaling affecting cancer cell drug sensitivity and effects on tumour drug uptake. PDGFRβ is an important regulator of fibroblasts. Experimental studies have linked PDGFRβ-positive fibroblasts to metastasis and also to reduced tumour drug uptake. This study has investigated the potential role of PDGFRβ-positive fibroblasts in response to adjuvant tamoxifen treatment of breast cancer. Analyses of two breast cancer collections from randomized studies analyzing adjuvant tamoxifen treatment in early breast cancer demonstrated significant benefit of tamoxifen in the group with low stromal PDGFRβ, which was not observed in the group with high stromal PDGFRβ. In general terms these findings provide novel evidence, derived from analyses of randomized clinical studies, of response-predictive capacity of a marker-defined subset of CAFs and, more specifically, identify stromal PDGFRβ as a marker related to tamoxifen benefit in early breast cancer.}}, author = {{Paulsson, J. and Rydén, Lisa and Strell, C and Frings, O and Tobin, Nicholas P and Fornander, T. and Bergh, J. and Landberg, Göran and Ståhl, O. and Östman, A.}}, issn = {{2056-4538}}, language = {{eng}}, number = {{1}}, pages = {{38--43}}, publisher = {{Wiley-Blackwell}}, series = {{The Journal of Pathology: Clinical Research}}, title = {{High expression of stromal PDGFRβ is associated with reduced benefit of tamoxifen in breast cancer}}, url = {{http://dx.doi.org/10.1002/cjp2.56}}, doi = {{10.1002/cjp2.56}}, volume = {{3}}, year = {{2017}}, }