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Plasma-free fatty acids, fatty acidebinding protein 4, and mortality in older adults (from the cardiovascular health study)

Miedema, Michael D. ; Maziarz, Marlena LU orcid ; Biggs, Mary L. ; Zieman, Susan J. ; Kizer, Jorge R. ; Ix, Joachim H. ; Mozaffarian, Dariush ; Tracy, Russell P. ; Psaty, Bruce M. and Siscovick, David S. , et al. (2014) In American Journal of Cardiology 114(6). p.843-848
Abstract

Plasma-free fatty acids (FFAs) are largely derived from adipose tissue. Elevated levels of FFA and fatty acidebinding protein 4 (FABP4), a key cytoplasmic chaperone of fatty acids, have been associated with adverse cardiovascular outcomes, but limited data are available on the relation of these biomarkers with cardiovascular and total mortality. We studied 4,707 participants with a mean age of 75 years who had plasma FFA and FABP4 measured in 1992 to 1993 as part of the Cardiovascular Health Study, an observational cohort of community-dwelling older adults. Over a median follow-up of 11.8 years, 3,555 participants died. Cox proportional hazard regression was used to determine the association between FFA, FABP4, and mortality. In fully... (More)

Plasma-free fatty acids (FFAs) are largely derived from adipose tissue. Elevated levels of FFA and fatty acidebinding protein 4 (FABP4), a key cytoplasmic chaperone of fatty acids, have been associated with adverse cardiovascular outcomes, but limited data are available on the relation of these biomarkers with cardiovascular and total mortality. We studied 4,707 participants with a mean age of 75 years who had plasma FFA and FABP4 measured in 1992 to 1993 as part of the Cardiovascular Health Study, an observational cohort of community-dwelling older adults. Over a median follow-up of 11.8 years, 3,555 participants died. Cox proportional hazard regression was used to determine the association between FFA, FABP4, and mortality. In fully adjusted models, FFA were associated with dosedependent significantly higher total mortality (hazard ratio [HR] per SD: 1.14, 95% confidence interval [CI] 1.09 to 1.18), but FABP4 levels were not (HR 1.04, 95% CI 0.98 to 1.09). In a cause-specific mortality analysis, higher concentrations of FFA were associated with significantly higher risk of death because of cardiovascular disease, dementia, infection, and respiratory causes but not cancer or trauma. We did not find evidence of an interaction between FFA and FABP4 (p[0.45), but FABP4 appeared to be associated with total mortality differentially in men and women (HR 1.17, 95% CI 1.08 to 1.26 for men; HR 1.02, 95% CI 0.96 to 1.07 for women, interaction p value <0.001). In conclusion, in a cohort of community-dwelling older subjects, elevated plasma concentrations of FFA, but not FABP4, were associated with cardiovascular and noncardiovascular mortality.

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publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Cardiology
volume
114
issue
6
pages
6 pages
publisher
Excerpta Medica
external identifiers
  • pmid:25073566
  • scopus:84926193712
ISSN
0002-9149
DOI
10.1016/j.amjcard.2014.06.012
language
English
LU publication?
no
id
afbed9b2-1e40-401c-afa6-da9abcf5ac6f
date added to LUP
2019-08-05 12:01:16
date last changed
2025-04-04 14:40:00
@article{afbed9b2-1e40-401c-afa6-da9abcf5ac6f,
  abstract     = {{<p>Plasma-free fatty acids (FFAs) are largely derived from adipose tissue. Elevated levels of FFA and fatty acidebinding protein 4 (FABP4), a key cytoplasmic chaperone of fatty acids, have been associated with adverse cardiovascular outcomes, but limited data are available on the relation of these biomarkers with cardiovascular and total mortality. We studied 4,707 participants with a mean age of 75 years who had plasma FFA and FABP4 measured in 1992 to 1993 as part of the Cardiovascular Health Study, an observational cohort of community-dwelling older adults. Over a median follow-up of 11.8 years, 3,555 participants died. Cox proportional hazard regression was used to determine the association between FFA, FABP4, and mortality. In fully adjusted models, FFA were associated with dosedependent significantly higher total mortality (hazard ratio [HR] per SD: 1.14, 95% confidence interval [CI] 1.09 to 1.18), but FABP4 levels were not (HR 1.04, 95% CI 0.98 to 1.09). In a cause-specific mortality analysis, higher concentrations of FFA were associated with significantly higher risk of death because of cardiovascular disease, dementia, infection, and respiratory causes but not cancer or trauma. We did not find evidence of an interaction between FFA and FABP4 (p[0.45), but FABP4 appeared to be associated with total mortality differentially in men and women (HR 1.17, 95% CI 1.08 to 1.26 for men; HR 1.02, 95% CI 0.96 to 1.07 for women, interaction p value &lt;0.001). In conclusion, in a cohort of community-dwelling older subjects, elevated plasma concentrations of FFA, but not FABP4, were associated with cardiovascular and noncardiovascular mortality.</p>}},
  author       = {{Miedema, Michael D. and Maziarz, Marlena and Biggs, Mary L. and Zieman, Susan J. and Kizer, Jorge R. and Ix, Joachim H. and Mozaffarian, Dariush and Tracy, Russell P. and Psaty, Bruce M. and Siscovick, David S. and Mukamal, Kenneth J. and Djousse, Luc}},
  issn         = {{0002-9149}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{6}},
  pages        = {{843--848}},
  publisher    = {{Excerpta Medica}},
  series       = {{American Journal of Cardiology}},
  title        = {{Plasma-free fatty acids, fatty acidebinding protein 4, and mortality in older adults (from the cardiovascular health study)}},
  url          = {{http://dx.doi.org/10.1016/j.amjcard.2014.06.012}},
  doi          = {{10.1016/j.amjcard.2014.06.012}},
  volume       = {{114}},
  year         = {{2014}},
}