Pulmonary delivery systems for antimicrobial peptides
(2024) In Critical Reviews in Biotechnology 44(6). p.963-980- Abstract
Bacterial infections of the respiratory tract cause millions of deaths annually. Several diseases exist wherein (1) bacterial infection is the main cause of disease (e.g., tuberculosis and bacterial pneumonia), (2) bacterial infection is a consequence of disease and worsens the disease prognosis (e.g., cystic fibrosis), and (3) bacteria-triggered inflammation propagates the disease (e.g., chronic obstructive pulmonary disease). Current approaches to combat infections generally include long and aggressive antibiotic treatments, which challenge patient compliance, thereby making relapses common and contributing to the development of antibiotic resistance. Consequently, the proportion of infections that cannot be treated with conventional... (More)
Bacterial infections of the respiratory tract cause millions of deaths annually. Several diseases exist wherein (1) bacterial infection is the main cause of disease (e.g., tuberculosis and bacterial pneumonia), (2) bacterial infection is a consequence of disease and worsens the disease prognosis (e.g., cystic fibrosis), and (3) bacteria-triggered inflammation propagates the disease (e.g., chronic obstructive pulmonary disease). Current approaches to combat infections generally include long and aggressive antibiotic treatments, which challenge patient compliance, thereby making relapses common and contributing to the development of antibiotic resistance. Consequently, the proportion of infections that cannot be treated with conventional antibiotics is rapidly increasing, and novel therapies are urgently needed. In this context, antimicrobial peptides (AMPs) have received considerable attention as they may exhibit potent antimicrobial effects against antibiotic-resistant bacterial strains but with modest toxicity. In addition, some AMPs suppress inflammation and provide other host defense functions (motivating the alternative term host defense peptides (HDPs)). However, the delivery of AMPs is complicated because they are large, positively charged, and amphiphilic. As a result of this, AMP delivery systems have recently attracted attention. For airway infections, the currently investigated delivery approaches range from aerosols and dry powders to various self-assembly and nanoparticle carrier systems, as well as their combinations. In this paper, we discuss recent developments in the field, ranging from mechanistic mode-of-action studies to the application of these systems for combating bacterial infections in the airways.
(Less)
- author
- Caselli, Lucrezia LU ; Rodrigues, Gisele R. ; Franco, Octavio L. LU and Malmsten, Martin LU
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Antimicrobial, bacterial infection, drug delivery, lung, membrane, peptide
- in
- Critical Reviews in Biotechnology
- volume
- 44
- issue
- 6
- pages
- 963 - 980
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:37731338
- scopus:85171677513
- ISSN
- 0738-8551
- DOI
- 10.1080/07388551.2023.2254932
- language
- English
- LU publication?
- yes
- id
- b32cc2b8-c6d9-49b1-ab1b-c3028b2ffae4
- date added to LUP
- 2023-12-21 10:29:22
- date last changed
- 2025-01-27 15:13:07
@article{b32cc2b8-c6d9-49b1-ab1b-c3028b2ffae4,
abstract = {{<p>Bacterial infections of the respiratory tract cause millions of deaths annually. Several diseases exist wherein (1) bacterial infection is the main cause of disease (e.g., tuberculosis and bacterial pneumonia), (2) bacterial infection is a consequence of disease and worsens the disease prognosis (e.g., cystic fibrosis), and (3) bacteria-triggered inflammation propagates the disease (e.g., chronic obstructive pulmonary disease). Current approaches to combat infections generally include long and aggressive antibiotic treatments, which challenge patient compliance, thereby making relapses common and contributing to the development of antibiotic resistance. Consequently, the proportion of infections that cannot be treated with conventional antibiotics is rapidly increasing, and novel therapies are urgently needed. In this context, antimicrobial peptides (AMPs) have received considerable attention as they may exhibit potent antimicrobial effects against antibiotic-resistant bacterial strains but with modest toxicity. In addition, some AMPs suppress inflammation and provide other host defense functions (motivating the alternative term host defense peptides (HDPs)). However, the delivery of AMPs is complicated because they are large, positively charged, and amphiphilic. As a result of this, AMP delivery systems have recently attracted attention. For airway infections, the currently investigated delivery approaches range from aerosols and dry powders to various self-assembly and nanoparticle carrier systems, as well as their combinations. In this paper, we discuss recent developments in the field, ranging from mechanistic mode-of-action studies to the application of these systems for combating bacterial infections in the airways.</p>}},
author = {{Caselli, Lucrezia and Rodrigues, Gisele R. and Franco, Octavio L. and Malmsten, Martin}},
issn = {{0738-8551}},
keywords = {{Antimicrobial; bacterial infection; drug delivery; lung; membrane; peptide}},
language = {{eng}},
number = {{6}},
pages = {{963--980}},
publisher = {{Informa Healthcare}},
series = {{Critical Reviews in Biotechnology}},
title = {{Pulmonary delivery systems for antimicrobial peptides}},
url = {{http://dx.doi.org/10.1080/07388551.2023.2254932}},
doi = {{10.1080/07388551.2023.2254932}},
volume = {{44}},
year = {{2024}},
}