Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Primary treatment patterns and survival of cervical cancer in Sweden : A population-based Swedish Gynecologic Cancer Group Study

Bjurberg, Maria LU ; Holmberg, Erik ; Borgfeldt, Christer LU ; Flöter-Rådestad, Angelique ; Dahm-Kähler, Pernilla ; Hjerpe, Elisabet ; Högberg, Thomas LU ; Kjølhede, Preben ; Marcickiewicz, Janusz and Rosenberg, Per , et al. (2019) In Gynecologic Oncology 155(2). p.229-236
Abstract

Objective: Survival in cervical cancer has improved little over the last decades. We aimed to elucidate primary treatment patterns and survival. Methods: Population-based study of patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed 2011–2015. Main outcome was 5-year relative survival (RS). Age-standardised RS (AS-RS) was estimated for the total cohort and for the pooled study population of squamous, adenosquamous-, adenocarcinoma. Results: Median follow-up time was 4.6 years. The study population consisted of 2141 patients; 97% of the 2212 patients in the total cohort and the 5-year AS-RS was 71% and 70%, respectively. RS stage IB1: surgery alone 95% vs. 72% for definitive chemoradiotherapy (CT-RT) (p <... (More)

Objective: Survival in cervical cancer has improved little over the last decades. We aimed to elucidate primary treatment patterns and survival. Methods: Population-based study of patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed 2011–2015. Main outcome was 5-year relative survival (RS). Age-standardised RS (AS-RS) was estimated for the total cohort and for the pooled study population of squamous, adenosquamous-, adenocarcinoma. Results: Median follow-up time was 4.6 years. The study population consisted of 2141 patients; 97% of the 2212 patients in the total cohort and the 5-year AS-RS was 71% and 70%, respectively. RS stage IB1: surgery alone 95% vs. 72% for definitive chemoradiotherapy (CT-RT) (p < 0.001). In stage IIA1 74% had CT-RT, and 47% of operated patients received adjuvant (CT)-RT. RS stage IB2: surgically treated 81% (69% received adjuvant (CT)-RT) vs. 76% for (CT)-RT (p = 0.73). RS stage IIB: 77% for CT-RT + brachytherapy (BT), 37% for RT + BT (p = 0.045) and 27% for RT-BT (p < 0.001). Stages III-IVA; <40% received CT-RT + BT, RS 45% vs. 18% for RT-BT (RR 4.1, p < 0.001). RS stage IVB 7%. Conclusion: Primary treatment of cervical cancer in Sweden adhered to evidence-based standard of care. Areas of improvement include optimising treatment for stages III-IVA, and avoiding combining surgery and radiotherapy.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cervical cancer, Radiotherapy, Surgery, Survival, Treatment
in
Gynecologic Oncology
volume
155
issue
2
pages
8 pages
publisher
Academic Press
external identifiers
  • pmid:31477283
  • scopus:85071486769
ISSN
0090-8258
DOI
10.1016/j.ygyno.2019.08.022
language
English
LU publication?
yes
id
b821bca2-5168-400c-b479-bb42d58248ab
date added to LUP
2019-09-19 12:27:47
date last changed
2024-04-16 21:10:57
@article{b821bca2-5168-400c-b479-bb42d58248ab,
  abstract     = {{<p>Objective: Survival in cervical cancer has improved little over the last decades. We aimed to elucidate primary treatment patterns and survival. Methods: Population-based study of patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed 2011–2015. Main outcome was 5-year relative survival (RS). Age-standardised RS (AS-RS) was estimated for the total cohort and for the pooled study population of squamous, adenosquamous-, adenocarcinoma. Results: Median follow-up time was 4.6 years. The study population consisted of 2141 patients; 97% of the 2212 patients in the total cohort and the 5-year AS-RS was 71% and 70%, respectively. RS stage IB1: surgery alone 95% vs. 72% for definitive chemoradiotherapy (CT-RT) (p &lt; 0.001). In stage IIA1 74% had CT-RT, and 47% of operated patients received adjuvant (CT)-RT. RS stage IB2: surgically treated 81% (69% received adjuvant (CT)-RT) vs. 76% for (CT)-RT (p = 0.73). RS stage IIB: 77% for CT-RT + brachytherapy (BT), 37% for RT + BT (p = 0.045) and 27% for RT-BT (p &lt; 0.001). Stages III-IVA; &lt;40% received CT-RT + BT, RS 45% vs. 18% for RT-BT (RR 4.1, p &lt; 0.001). RS stage IVB 7%. Conclusion: Primary treatment of cervical cancer in Sweden adhered to evidence-based standard of care. Areas of improvement include optimising treatment for stages III-IVA, and avoiding combining surgery and radiotherapy.</p>}},
  author       = {{Bjurberg, Maria and Holmberg, Erik and Borgfeldt, Christer and Flöter-Rådestad, Angelique and Dahm-Kähler, Pernilla and Hjerpe, Elisabet and Högberg, Thomas and Kjølhede, Preben and Marcickiewicz, Janusz and Rosenberg, Per and Stålberg, Karin and Tholander, Bengt and Hellman, Kristina and Åvall-Lundqvist, Elisabeth}},
  issn         = {{0090-8258}},
  keywords     = {{Cervical cancer; Radiotherapy; Surgery; Survival; Treatment}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{229--236}},
  publisher    = {{Academic Press}},
  series       = {{Gynecologic Oncology}},
  title        = {{Primary treatment patterns and survival of cervical cancer in Sweden : A population-based Swedish Gynecologic Cancer Group Study}},
  url          = {{http://dx.doi.org/10.1016/j.ygyno.2019.08.022}},
  doi          = {{10.1016/j.ygyno.2019.08.022}},
  volume       = {{155}},
  year         = {{2019}},
}