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Outdoor air pollution from industrial chemicals causing new onset of asthma or COPD : a systematic review protocol

Lux, Harald ; Baur, Xaver ; Budnik, Lygia Therese ; Heutelbeck, Astrid ; Teixeira, João Paulo ; Neumann, Emeri ; Adliene, Diana ; Puišo, Judita ; Lucas, David and Löndahl, Jakob LU orcid , et al. (2020) In Journal of Occupational Medicine and Toxicology 15(1).
Abstract

Background: Until today, industrial sources contribute to the multifaceted contamination of environmental air. Exposure to air pollutants has the potential to initiate and promote asthma and chronic obstructive pulmonary disease (COPD). At global scale, both entities cause the majority of about 4 million annual deaths by respiratory disease. However, we identified industrial contamination as a subgroup of air pollution that may be associated with this burden and is underinvestigated in research. Therefore, the aim of this study is to investigate associations between substances industrially released into environmental air and the occurrence of asthma and COPD in the human population. Here we present the protocol for our systematic review... (More)

Background: Until today, industrial sources contribute to the multifaceted contamination of environmental air. Exposure to air pollutants has the potential to initiate and promote asthma and chronic obstructive pulmonary disease (COPD). At global scale, both entities cause the majority of about 4 million annual deaths by respiratory disease. However, we identified industrial contamination as a subgroup of air pollution that may be associated with this burden and is underinvestigated in research. Therefore, the aim of this study is to investigate associations between substances industrially released into environmental air and the occurrence of asthma and COPD in the human population. Here we present the protocol for our systematic review of the current evidence. Methods: The following determinations will be applied during the systematic review process and are specified in the protocol that complies with the PRISMA-P statement. Populations of children and adults, as well as outdoor workers, exposed to industrially released air pollutants are of interest. Eligible studies may include subjects as controls who are non- or less exposed to the investigated air pollutants. The outcomes new-onset asthma and/or COPD investigated with risk ratio, odds ratio, hazard ratio, incidence rate ratio, cumulative incidence, and incidence rate are eligible. We will search the electronic literature databases EMBASE, MEDLINE, and Web of Science for peer-reviewed reports of incidence studies and incidence case-control studies. After systematic sorting of initial records, included studies will be subjected to quality assessment. Data will be synthesized qualitatively and, if appropriate, quantitatively for risk ratio and odds ratio. We will maintain and provide a PRISMA report. Discussion: Results of this systematic review may indicate alterations of incidence and risk of asthma and/or COPD in populations within industrial exposure radiuses including outdoor workplaces. Specific causal substances and compositions will be identified, but results will depend on the exposure assessment of the eligible studies. Our approach covers effects of industrial contributions to overall air pollution if studies reportedly attribute investigated emissions to industry. Results of this study may raise the question wether the available higher-level evidence sufficiently covers the current scale of industrial exposure scenarios and their potential harm to respiratory health. Trial registration: This protocol was registered in PROSPERO, registration number CRD42020151573.

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Contribution to journal
publication status
published
subject
keywords
Air pollution, Chronic obstructive pulmonary disease, Inhaled particles, Occupational exposure, Outdoor exposure, Respiratory disease, Systematic literature review
in
Journal of Occupational Medicine and Toxicology
volume
15
issue
1
article number
38
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85098243839
  • pmid:33371904
ISSN
1745-6673
DOI
10.1186/s12995-020-00289-6
language
English
LU publication?
yes
id
b87136b0-39a0-40e9-b3fa-c41a8127d80a
date added to LUP
2021-01-07 14:44:38
date last changed
2024-06-27 05:28:33
@article{b87136b0-39a0-40e9-b3fa-c41a8127d80a,
  abstract     = {{<p>Background: Until today, industrial sources contribute to the multifaceted contamination of environmental air. Exposure to air pollutants has the potential to initiate and promote asthma and chronic obstructive pulmonary disease (COPD). At global scale, both entities cause the majority of about 4 million annual deaths by respiratory disease. However, we identified industrial contamination as a subgroup of air pollution that may be associated with this burden and is underinvestigated in research. Therefore, the aim of this study is to investigate associations between substances industrially released into environmental air and the occurrence of asthma and COPD in the human population. Here we present the protocol for our systematic review of the current evidence. Methods: The following determinations will be applied during the systematic review process and are specified in the protocol that complies with the PRISMA-P statement. Populations of children and adults, as well as outdoor workers, exposed to industrially released air pollutants are of interest. Eligible studies may include subjects as controls who are non- or less exposed to the investigated air pollutants. The outcomes new-onset asthma and/or COPD investigated with risk ratio, odds ratio, hazard ratio, incidence rate ratio, cumulative incidence, and incidence rate are eligible. We will search the electronic literature databases EMBASE, MEDLINE, and Web of Science for peer-reviewed reports of incidence studies and incidence case-control studies. After systematic sorting of initial records, included studies will be subjected to quality assessment. Data will be synthesized qualitatively and, if appropriate, quantitatively for risk ratio and odds ratio. We will maintain and provide a PRISMA report. Discussion: Results of this systematic review may indicate alterations of incidence and risk of asthma and/or COPD in populations within industrial exposure radiuses including outdoor workplaces. Specific causal substances and compositions will be identified, but results will depend on the exposure assessment of the eligible studies. Our approach covers effects of industrial contributions to overall air pollution if studies reportedly attribute investigated emissions to industry. Results of this study may raise the question wether the available higher-level evidence sufficiently covers the current scale of industrial exposure scenarios and their potential harm to respiratory health. Trial registration: This protocol was registered in PROSPERO, registration number CRD42020151573.</p>}},
  author       = {{Lux, Harald and Baur, Xaver and Budnik, Lygia Therese and Heutelbeck, Astrid and Teixeira, João Paulo and Neumann, Emeri and Adliene, Diana and Puišo, Judita and Lucas, David and Löndahl, Jakob and Damialis, Athanasios and Goksel, Ozlem and Orru, Hans}},
  issn         = {{1745-6673}},
  keywords     = {{Air pollution; Chronic obstructive pulmonary disease; Inhaled particles; Occupational exposure; Outdoor exposure; Respiratory disease; Systematic literature review}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Journal of Occupational Medicine and Toxicology}},
  title        = {{Outdoor air pollution from industrial chemicals causing new onset of asthma or COPD : a systematic review protocol}},
  url          = {{http://dx.doi.org/10.1186/s12995-020-00289-6}},
  doi          = {{10.1186/s12995-020-00289-6}},
  volume       = {{15}},
  year         = {{2020}},
}