Gene expression signature of acquired chemoresistance in neuroblastoma cells
(2020) In International Journal of Molecular Sciences 21(18).- Abstract
Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. Patients with relapsed disease have a poor prognosis despite intense treatment. In the present study, we aimed to identify chemoresistance gene expression signatures in vincristine resistant neuroblastoma cells. We found that vincristine-resistant neuroblastoma cells formed larger clones and survived under reduced serum conditions as compared with non-resistant parental cells. To identify the possible mechanisms underlying vincristine resistance in neuroblastoma cells, we investigated the expression profiles of genes known to be involved in cancer drug resistance. This specific gene expression patterns could predict the behavior of a tumor in response to... (More)
Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. Patients with relapsed disease have a poor prognosis despite intense treatment. In the present study, we aimed to identify chemoresistance gene expression signatures in vincristine resistant neuroblastoma cells. We found that vincristine-resistant neuroblastoma cells formed larger clones and survived under reduced serum conditions as compared with non-resistant parental cells. To identify the possible mechanisms underlying vincristine resistance in neuroblastoma cells, we investigated the expression profiles of genes known to be involved in cancer drug resistance. This specific gene expression patterns could predict the behavior of a tumor in response to chemotherapy and for predicting the prognosis of high-risk neuroblastoma patients. Our signature could help chemoresistant neuroblastoma patients in avoiding useless and harmful chemotherapy cycles.
(Less)
- author
- Jemaà, Mohamed LU ; Sime, Wondossen LU ; Abassi, Yasmin LU ; Lasorsa, Vito Alessandro ; Køhler, Julie Bonne LU ; Michaelis, Martin ; Cinatl, Jindrich ; Capasso, Mario and Massoumi, Ramin LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Chemoresistance, Neuroblastoma, Vincristine
- in
- International Journal of Molecular Sciences
- volume
- 21
- issue
- 18
- article number
- 6811
- pages
- 15 pages
- publisher
- MDPI AG
- external identifiers
-
- scopus:85090874627
- pmid:32948088
- ISSN
- 1661-6596
- DOI
- 10.3390/ijms21186811
- language
- English
- LU publication?
- yes
- id
- ba28ae18-8de7-40cf-b948-adca845208c5
- date added to LUP
- 2020-09-29 15:55:06
- date last changed
- 2024-08-08 03:09:26
@article{ba28ae18-8de7-40cf-b948-adca845208c5, abstract = {{<p>Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. Patients with relapsed disease have a poor prognosis despite intense treatment. In the present study, we aimed to identify chemoresistance gene expression signatures in vincristine resistant neuroblastoma cells. We found that vincristine-resistant neuroblastoma cells formed larger clones and survived under reduced serum conditions as compared with non-resistant parental cells. To identify the possible mechanisms underlying vincristine resistance in neuroblastoma cells, we investigated the expression profiles of genes known to be involved in cancer drug resistance. This specific gene expression patterns could predict the behavior of a tumor in response to chemotherapy and for predicting the prognosis of high-risk neuroblastoma patients. Our signature could help chemoresistant neuroblastoma patients in avoiding useless and harmful chemotherapy cycles.</p>}}, author = {{Jemaà, Mohamed and Sime, Wondossen and Abassi, Yasmin and Lasorsa, Vito Alessandro and Køhler, Julie Bonne and Michaelis, Martin and Cinatl, Jindrich and Capasso, Mario and Massoumi, Ramin}}, issn = {{1661-6596}}, keywords = {{Chemoresistance; Neuroblastoma; Vincristine}}, language = {{eng}}, number = {{18}}, publisher = {{MDPI AG}}, series = {{International Journal of Molecular Sciences}}, title = {{Gene expression signature of acquired chemoresistance in neuroblastoma cells}}, url = {{http://dx.doi.org/10.3390/ijms21186811}}, doi = {{10.3390/ijms21186811}}, volume = {{21}}, year = {{2020}}, }