Transportation noise and risk of stroke : a nationwide prospective cohort study covering Denmark
(2021) In International Journal of Epidemiology 50(4). p.1147-1156- Abstract
BACKGROUND: Studies on transportation noise and incident stroke are few and inconclusive. We aimed to investigate associations between road-traffic and railway noise and the risk of incident stroke in the entire Danish population.
METHODS: We estimated road-traffic and railway noise (Lden) at the most and least exposed façades for all residential addresses across Denmark (2.8 million) for the period 1990-2017. Based on this, we estimated the 10-year time-weighted mean noise exposure for 3.6 million Danes aged >35 years, of whom 184 523 developed incident stroke during follow-up from 2000 to 2017. Analyses were conducted using Cox proportional-hazards models, with adjustment for various individual- and area-level demographic and... (More)
BACKGROUND: Studies on transportation noise and incident stroke are few and inconclusive. We aimed to investigate associations between road-traffic and railway noise and the risk of incident stroke in the entire Danish population.
METHODS: We estimated road-traffic and railway noise (Lden) at the most and least exposed façades for all residential addresses across Denmark (2.8 million) for the period 1990-2017. Based on this, we estimated the 10-year time-weighted mean noise exposure for 3.6 million Danes aged >35 years, of whom 184 523 developed incident stroke during follow-up from 2000 to 2017. Analyses were conducted using Cox proportional-hazards models, with adjustment for various individual- and area-level demographic and socio-economic covariates collected from registries and air pollution [fine particulate matter with particles with a diameter of ≤2.5 µm (PM2.5) and nitrogen dioxide (NO2)].
RESULTS: A 10-dB increase in the 10-year mean road-traffic noise at the most exposed façade was associated with an incidence rate ratio (IRR) of 1.04 [95% confidence interval (CI): 1.03-1.05] for all strokes. For road-traffic noise at the least exposed façade, the IRR per 10 dB was 1.03 (95% CI: 1.02-1.04) for all strokes. Railway noise was not associated with a higher risk of stroke.
CONCLUSION: Road-traffic noise increased the risk of stroke. These findings add to the evidence of road-traffic noise as a cardiovascular risk factor.
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- author
- Sørensen, Mette ; Poulsen, Aslak Harbo ; Hvidtfeldt, Ulla Arthur ; Münzel, Thomas ; Thacher, Jesse Daniel LU ; Ketzel, Matthias LU ; Brandt, Jørgen ; Christensen, Jesper H ; Levin, Gregor and Raaschou-Nielsen, Ole
- publishing date
- 2021-08-30
- type
- Contribution to journal
- publication status
- published
- keywords
- Air Pollution/adverse effects, Denmark/epidemiology, Environmental Exposure/adverse effects, Humans, Noise, Transportation/adverse effects, Prospective Studies, Stroke/epidemiology
- in
- International Journal of Epidemiology
- volume
- 50
- issue
- 4
- pages
- 1147 - 1156
- publisher
- Oxford University Press
- external identifiers
-
- pmid:33755127
- scopus:85114791156
- ISSN
- 1464-3685
- DOI
- 10.1093/ije/dyab024
- language
- English
- LU publication?
- no
- additional info
- © The Author(s) 2021; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.
- id
- bbf0b5e3-67ae-468f-b8d2-d6e295d3ab23
- date added to LUP
- 2023-05-08 10:49:55
- date last changed
- 2024-12-14 22:38:18
@article{bbf0b5e3-67ae-468f-b8d2-d6e295d3ab23,
abstract = {{<p>BACKGROUND: Studies on transportation noise and incident stroke are few and inconclusive. We aimed to investigate associations between road-traffic and railway noise and the risk of incident stroke in the entire Danish population.</p><p>METHODS: We estimated road-traffic and railway noise (Lden) at the most and least exposed façades for all residential addresses across Denmark (2.8 million) for the period 1990-2017. Based on this, we estimated the 10-year time-weighted mean noise exposure for 3.6 million Danes aged >35 years, of whom 184 523 developed incident stroke during follow-up from 2000 to 2017. Analyses were conducted using Cox proportional-hazards models, with adjustment for various individual- and area-level demographic and socio-economic covariates collected from registries and air pollution [fine particulate matter with particles with a diameter of ≤2.5 µm (PM2.5) and nitrogen dioxide (NO2)].</p><p>RESULTS: A 10-dB increase in the 10-year mean road-traffic noise at the most exposed façade was associated with an incidence rate ratio (IRR) of 1.04 [95% confidence interval (CI): 1.03-1.05] for all strokes. For road-traffic noise at the least exposed façade, the IRR per 10 dB was 1.03 (95% CI: 1.02-1.04) for all strokes. Railway noise was not associated with a higher risk of stroke.</p><p>CONCLUSION: Road-traffic noise increased the risk of stroke. These findings add to the evidence of road-traffic noise as a cardiovascular risk factor.</p>}},
author = {{Sørensen, Mette and Poulsen, Aslak Harbo and Hvidtfeldt, Ulla Arthur and Münzel, Thomas and Thacher, Jesse Daniel and Ketzel, Matthias and Brandt, Jørgen and Christensen, Jesper H and Levin, Gregor and Raaschou-Nielsen, Ole}},
issn = {{1464-3685}},
keywords = {{Air Pollution/adverse effects; Denmark/epidemiology; Environmental Exposure/adverse effects; Humans; Noise, Transportation/adverse effects; Prospective Studies; Stroke/epidemiology}},
language = {{eng}},
month = {{08}},
number = {{4}},
pages = {{1147--1156}},
publisher = {{Oxford University Press}},
series = {{International Journal of Epidemiology}},
title = {{Transportation noise and risk of stroke : a nationwide prospective cohort study covering Denmark}},
url = {{http://dx.doi.org/10.1093/ije/dyab024}},
doi = {{10.1093/ije/dyab024}},
volume = {{50}},
year = {{2021}},
}