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International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer : Working Group 3: Subcategorization of T1 Bladder Cancer

Lopez-Beltran, Antonio ; Raspollini, Maria R. ; Hansel, Donna ; Compérat, Eva ; Williamson, Sean R. ; Liedberg, Fredrik LU ; Iczkowski, Kenneth A. ; Bubendorf, Lukas ; Van Der Kwast, Theodorus H. and Cheng, Liang (2024) In American Journal of Surgical Pathology 48(1). p.24-31
Abstract

Emerging data on T1 bladder cancer subcategorization (aka substaging) suggests a correlation with oncological outcomes. The International Society of Urological Pathology (ISUP) organized the 2022 consensus conference in Basel, Switzerland to focus on current issues in bladder cancer and tasked working group 3 to make recommendations for T1 subcategorization in transurethral bladder resections. For this purpose, the ISUP developed and circulated a survey to their membership querying approaches to T1 bladder cancer subcategorization. In particular, clinical relevance, pathological reporting, and endorsement of T1 subcategorization in the daily practice of pathology were surveyed. Of the respondents of the premeeting survey, about 40% do... (More)

Emerging data on T1 bladder cancer subcategorization (aka substaging) suggests a correlation with oncological outcomes. The International Society of Urological Pathology (ISUP) organized the 2022 consensus conference in Basel, Switzerland to focus on current issues in bladder cancer and tasked working group 3 to make recommendations for T1 subcategorization in transurethral bladder resections. For this purpose, the ISUP developed and circulated a survey to their membership querying approaches to T1 bladder cancer subcategorization. In particular, clinical relevance, pathological reporting, and endorsement of T1 subcategorization in the daily practice of pathology were surveyed. Of the respondents of the premeeting survey, about 40% do not routinely report T1 subcategory. We reviewed literature on bladder T1 subcategorization, and screened selected articles for clinical performance and practicality of T1 subcategorization methods. Published literature offered evidence of the clinical rationale for T1 subcategorization and at the conference consensus (83% of conference attendants) was obtained to report routinely T1 subcategorization of transurethral resections. Semiquantitative T1 subcategorization was favored (37%) over histoanatomic methods (4%). This is in line with literature findings on practicality and prognostic impact, that is, a shift of publications from histoanatomic to semiquantitative methods or by reports incorporating both methodologies is apparent over the last decade. However, 59% of participants had no preference for either methodology. They would add a comment in the report briefly stating applied method, interpretation criteria (including cutoff), and potential limitations. When queried on the terminology of T1 subcategorization, 34% and 20% of participants were in favor of T1 (microinvasive) versus T1 (extensive) or T1 (focal) versus T1 (nonfocal), respectively.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
muscularis mucosae, prognostic, T1 bladder cancer, T1 subcategorization
in
American Journal of Surgical Pathology
volume
48
issue
1
pages
24 - 31
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85180417593
  • pmid:37737692
ISSN
0147-5185
DOI
10.1097/PAS.0000000000002121
language
English
LU publication?
yes
id
bef298ca-aa45-4f5e-9c6a-5f3fbf371626
date added to LUP
2024-01-31 13:58:11
date last changed
2025-02-06 08:00:03
@article{bef298ca-aa45-4f5e-9c6a-5f3fbf371626,
  abstract     = {{<p>Emerging data on T1 bladder cancer subcategorization (aka substaging) suggests a correlation with oncological outcomes. The International Society of Urological Pathology (ISUP) organized the 2022 consensus conference in Basel, Switzerland to focus on current issues in bladder cancer and tasked working group 3 to make recommendations for T1 subcategorization in transurethral bladder resections. For this purpose, the ISUP developed and circulated a survey to their membership querying approaches to T1 bladder cancer subcategorization. In particular, clinical relevance, pathological reporting, and endorsement of T1 subcategorization in the daily practice of pathology were surveyed. Of the respondents of the premeeting survey, about 40% do not routinely report T1 subcategory. We reviewed literature on bladder T1 subcategorization, and screened selected articles for clinical performance and practicality of T1 subcategorization methods. Published literature offered evidence of the clinical rationale for T1 subcategorization and at the conference consensus (83% of conference attendants) was obtained to report routinely T1 subcategorization of transurethral resections. Semiquantitative T1 subcategorization was favored (37%) over histoanatomic methods (4%). This is in line with literature findings on practicality and prognostic impact, that is, a shift of publications from histoanatomic to semiquantitative methods or by reports incorporating both methodologies is apparent over the last decade. However, 59% of participants had no preference for either methodology. They would add a comment in the report briefly stating applied method, interpretation criteria (including cutoff), and potential limitations. When queried on the terminology of T1 subcategorization, 34% and 20% of participants were in favor of T1 (microinvasive) versus T1 (extensive) or T1 (focal) versus T1 (nonfocal), respectively.</p>}},
  author       = {{Lopez-Beltran, Antonio and Raspollini, Maria R. and Hansel, Donna and Compérat, Eva and Williamson, Sean R. and Liedberg, Fredrik and Iczkowski, Kenneth A. and Bubendorf, Lukas and Van Der Kwast, Theodorus H. and Cheng, Liang}},
  issn         = {{0147-5185}},
  keywords     = {{muscularis mucosae; prognostic; T1 bladder cancer; T1 subcategorization}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{24--31}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{American Journal of Surgical Pathology}},
  title        = {{International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer : Working Group 3: Subcategorization of T1 Bladder Cancer}},
  url          = {{http://dx.doi.org/10.1097/PAS.0000000000002121}},
  doi          = {{10.1097/PAS.0000000000002121}},
  volume       = {{48}},
  year         = {{2024}},
}