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Thrombotic risk determined by ABO, F8, and VWF variants in a population-based cohort study

Manderstedt, Eric LU ; Halldén, Christer LU ; Lind-Halldén, Christina LU ; Elf, Johan LU ; Svensson, Peter J. LU ; Engström, Gunnar LU ; Melander, Olle LU orcid ; Baras, Aris ; Lotta, Luca A. and Abecasis, Goncalo , et al. (2025) In Research and practice in thrombosis and haemostasis 9(4).
Abstract
Background Von Willebrand factor (VWF) and coagulation factor VIII (FVIII) plasma levels are associated with increased risk for venous thromboembolism (VTE). Objectives This study aimed to determine the thrombotic risk of rare and common variants of 27 genes linked to VWF or FVIII plasma levels in genome-wide association studies. Methods Exon sequences of 27 genes linked to plasma levels of VWF or FVIII in genome-wide association studies were analyzed for common and rare variants in 28,794 subjects without VTE (born during 1923-1950, 60% women), who participated in the Malmö Diet and Cancer study (1991-1996), with a follow-up time until 2018. Hazard ratios (HRs) were determined. P values were Bonferroni-corrected (P value = .05/27
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ABO blood-group system, factor VIII, molecular epidemiology, venous thromboembolism, von Willebrand factor
in
Research and practice in thrombosis and haemostasis
volume
9
issue
4
article number
102875
publisher
Wiley
external identifiers
  • scopus:105005072275
ISSN
2475-0379
DOI
10.1016/j.rpth.2025.102875
project
Genetic analysis of venous thromboembolism, peripheral artery disease, and varicose veins: Analysis of GWAS, WES and WGS data and evaluation of the clinical significance of associated variants
language
English
LU publication?
yes
id
c1ad7636-6657-4a89-a278-9d462280e053
alternative location
https://www.sciencedirect.com/science/article/pii/S2475037925001992
date added to LUP
2025-05-23 11:58:20
date last changed
2025-06-21 05:16:24
@article{c1ad7636-6657-4a89-a278-9d462280e053,
  abstract     = {{Background Von Willebrand factor (VWF) and coagulation factor VIII (FVIII) plasma levels are associated with increased risk for venous thromboembolism (VTE). Objectives This study aimed to determine the thrombotic risk of rare and common variants of 27 genes linked to VWF or FVIII plasma levels in genome-wide association studies. Methods Exon sequences of 27 genes linked to plasma levels of VWF or FVIII in genome-wide association studies were analyzed for common and rare variants in 28,794 subjects without VTE (born during 1923-1950, 60% women), who participated in the Malmö Diet and Cancer study (1991-1996), with a follow-up time until 2018. Hazard ratios (HRs) were determined. P values were Bonferroni-corrected (P value = .05/27}},
  author       = {{Manderstedt, Eric and Halldén, Christer and Lind-Halldén, Christina and Elf, Johan and Svensson, Peter J. and Engström, Gunnar and Melander, Olle and Baras, Aris and Lotta, Luca A. and Abecasis, Goncalo and Cantor, Michael and Coppola, Giovanni and Economides, Aris and Overton, John D. and Reid, Jeffrey G. and Shuldiner, Alan and Zöller, Bengt}},
  issn         = {{2475-0379}},
  keywords     = {{ABO blood-group system; factor VIII; molecular epidemiology; venous thromboembolism; von Willebrand factor}},
  language     = {{eng}},
  number       = {{4}},
  publisher    = {{Wiley}},
  series       = {{Research and practice in thrombosis and haemostasis}},
  title        = {{Thrombotic risk determined by ABO, F8, and VWF variants in a population-based cohort study}},
  url          = {{http://dx.doi.org/10.1016/j.rpth.2025.102875}},
  doi          = {{10.1016/j.rpth.2025.102875}},
  volume       = {{9}},
  year         = {{2025}},
}