Genetic predisposition for multiple myeloma
(2020) In Leukemia 34(3). p.697-708- Abstract
Multiple myeloma (MM) is the second most common blood malignancy. Epidemiological family studies going back to the 1920s have provided evidence for familial aggregation, suggesting a subset of cases have an inherited genetic background. Recently, studies aimed at explaining this phenomenon have begun to provide direct evidence for genetic predisposition to MM. Genome-wide association studies have identified common risk alleles at 24 independent loci. Sequencing studies of familial cases and kindreds have begun to identify promising candidate genes where variants with strong effects on MM risk might reside. Finally, functional studies are starting to give insight into how identified risk alleles promote the development of MM. Here, we... (More)
Multiple myeloma (MM) is the second most common blood malignancy. Epidemiological family studies going back to the 1920s have provided evidence for familial aggregation, suggesting a subset of cases have an inherited genetic background. Recently, studies aimed at explaining this phenomenon have begun to provide direct evidence for genetic predisposition to MM. Genome-wide association studies have identified common risk alleles at 24 independent loci. Sequencing studies of familial cases and kindreds have begun to identify promising candidate genes where variants with strong effects on MM risk might reside. Finally, functional studies are starting to give insight into how identified risk alleles promote the development of MM. Here, we review recent findings in MM predisposition field, and highlight open questions and future directions.
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- author
- Pertesi, Maroulio LU ; Went, Molly ; Hansson, Markus LU ; Hemminki, Kari LU ; Houlston, Richard S. and Nilsson, Björn LU
- organization
- publishing date
- 2020-03
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Leukemia
- volume
- 34
- issue
- 3
- pages
- 12 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:31913320
- scopus:85077707182
- ISSN
- 0887-6924
- DOI
- 10.1038/s41375-019-0703-6
- language
- English
- LU publication?
- yes
- id
- c26d4667-9389-425b-8eab-5c4115dea17a
- date added to LUP
- 2020-01-29 14:14:35
- date last changed
- 2024-08-22 14:00:48
@article{c26d4667-9389-425b-8eab-5c4115dea17a, abstract = {{<p>Multiple myeloma (MM) is the second most common blood malignancy. Epidemiological family studies going back to the 1920s have provided evidence for familial aggregation, suggesting a subset of cases have an inherited genetic background. Recently, studies aimed at explaining this phenomenon have begun to provide direct evidence for genetic predisposition to MM. Genome-wide association studies have identified common risk alleles at 24 independent loci. Sequencing studies of familial cases and kindreds have begun to identify promising candidate genes where variants with strong effects on MM risk might reside. Finally, functional studies are starting to give insight into how identified risk alleles promote the development of MM. Here, we review recent findings in MM predisposition field, and highlight open questions and future directions.</p>}}, author = {{Pertesi, Maroulio and Went, Molly and Hansson, Markus and Hemminki, Kari and Houlston, Richard S. and Nilsson, Björn}}, issn = {{0887-6924}}, language = {{eng}}, number = {{3}}, pages = {{697--708}}, publisher = {{Nature Publishing Group}}, series = {{Leukemia}}, title = {{Genetic predisposition for multiple myeloma}}, url = {{http://dx.doi.org/10.1038/s41375-019-0703-6}}, doi = {{10.1038/s41375-019-0703-6}}, volume = {{34}}, year = {{2020}}, }