Predictive value of sarcopenia components for all-cause mortality : findings from population-based cohorts
(2024) In Aging clinical and experimental research 36(1).- Abstract
Background: Low grip strength and gait speed are associated with mortality. However, investigation of the additional mortality risk explained by these measures, over and above other factors, is limited. Aim: We examined whether grip strength and gait speed improve discriminative capacity for mortality over and above more readily obtainable clinical risk factors. Methods: Participants from the Health, Aging and Body Composition Study, Osteoporotic Fractures in Men Study, and the Hertfordshire Cohort Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over 2.4–6 m. Verified deaths were recorded. Associations between sarcopenia components and mortality were... (More)
Background: Low grip strength and gait speed are associated with mortality. However, investigation of the additional mortality risk explained by these measures, over and above other factors, is limited. Aim: We examined whether grip strength and gait speed improve discriminative capacity for mortality over and above more readily obtainable clinical risk factors. Methods: Participants from the Health, Aging and Body Composition Study, Osteoporotic Fractures in Men Study, and the Hertfordshire Cohort Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over 2.4–6 m. Verified deaths were recorded. Associations between sarcopenia components and mortality were examined using Cox regression with cohort as a random effect; discriminative capacity was assessed using Harrell’s Concordance Index (C-index). Results: Mean (SD) age of participants (n = 8362) was 73.8(5.1) years; 5231(62.6%) died during a median follow-up time of 13.3 years. Grip strength (hazard ratio (95% CI) per SD decrease: 1.14 (1.10,1.19)) and gait speed (1.21 (1.17,1.26)), but not ALM index (1.01 (0.95,1.06)), were associated with mortality in mutually-adjusted models after accounting for age, sex, BMI, smoking status, alcohol consumption, physical activity, ethnicity, education, history of fractures and falls, femoral neck bone mineral density (BMD), self-rated health, cognitive function and number of comorbidities. However, a model containing only age and sex as exposures gave a C-index (95% CI) of 0.65(0.64,0.66), which only increased to 0.67(0.67,0.68) after inclusion of grip strength and gait speed. Conclusions: Grip strength and gait speed may generate only modest adjunctive risk information for mortality compared with other more readily obtainable risk factors.
(Less)
- author
- organization
- publishing date
- 2024-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Ageing, Epidemiology, Mortality, Osteoporosis, Sarcopenia
- in
- Aging clinical and experimental research
- volume
- 36
- issue
- 1
- article number
- 126
- publisher
- Kurtis
- external identifiers
-
- scopus:85195360010
- pmid:38842791
- ISSN
- 1594-0667
- DOI
- 10.1007/s40520-024-02783-x
- language
- English
- LU publication?
- yes
- id
- c6eb611c-9e9c-4040-a074-f57571a03e64
- date added to LUP
- 2024-07-01 14:41:04
- date last changed
- 2024-07-01 14:42:31
@article{c6eb611c-9e9c-4040-a074-f57571a03e64,
abstract = {{<p>Background: Low grip strength and gait speed are associated with mortality. However, investigation of the additional mortality risk explained by these measures, over and above other factors, is limited. Aim: We examined whether grip strength and gait speed improve discriminative capacity for mortality over and above more readily obtainable clinical risk factors. Methods: Participants from the Health, Aging and Body Composition Study, Osteoporotic Fractures in Men Study, and the Hertfordshire Cohort Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over 2.4–6 m. Verified deaths were recorded. Associations between sarcopenia components and mortality were examined using Cox regression with cohort as a random effect; discriminative capacity was assessed using Harrell’s Concordance Index (C-index). Results: Mean (SD) age of participants (n = 8362) was 73.8(5.1) years; 5231(62.6%) died during a median follow-up time of 13.3 years. Grip strength (hazard ratio (95% CI) per SD decrease: 1.14 (1.10,1.19)) and gait speed (1.21 (1.17,1.26)), but not ALM index (1.01 (0.95,1.06)), were associated with mortality in mutually-adjusted models after accounting for age, sex, BMI, smoking status, alcohol consumption, physical activity, ethnicity, education, history of fractures and falls, femoral neck bone mineral density (BMD), self-rated health, cognitive function and number of comorbidities. However, a model containing only age and sex as exposures gave a C-index (95% CI) of 0.65(0.64,0.66), which only increased to 0.67(0.67,0.68) after inclusion of grip strength and gait speed. Conclusions: Grip strength and gait speed may generate only modest adjunctive risk information for mortality compared with other more readily obtainable risk factors.</p>}},
author = {{Westbury, Leo D. and Harvey, Nicholas C. and Beaudart, Charlotte and Bruyère, Olivier and Cauley, Jane A. and Cawthon, Peggy and Cruz-Jentoft, Alfonso J. and Curtis, Elizabeth M. and Ensrud, Kristine and Fielding, Roger A. and Johansson, Helena and Kanis, John A. and Karlsson, Magnus K. and Lane, Nancy E. and Lengelé, Laetitia and Lorentzon, Mattias and McCloskey, Eugene and Mellström, Dan and Newman, Anne B. and Ohlsson, Claes and Orwoll, Eric and Reginster, Jean Yves and Ribom, Eva and Rosengren, Björn E. and Schousboe, John T. and Dennison, Elaine M. and Cooper, Cyrus}},
issn = {{1594-0667}},
keywords = {{Ageing; Epidemiology; Mortality; Osteoporosis; Sarcopenia}},
language = {{eng}},
number = {{1}},
publisher = {{Kurtis}},
series = {{Aging clinical and experimental research}},
title = {{Predictive value of sarcopenia components for all-cause mortality : findings from population-based cohorts}},
url = {{http://dx.doi.org/10.1007/s40520-024-02783-x}},
doi = {{10.1007/s40520-024-02783-x}},
volume = {{36}},
year = {{2024}},
}