Decreasing prevalence of transmitted drug resistance among ART-naive HIV-1-infected patients in Iceland, 1996–2012
(2017) In Infection Ecology and Epidemiology 7(1).- Abstract
- Introduction: Resistance to antiretroviral drugs can complicate the management of HIV-1 infection and impair control of its spread. The aim of the current study was to investigate the prevalence and transmission of HIV-1 drug resistance among 106 antiretroviral therapy (ART)-naïve patients diagnosed in Iceland (1996–2012).
Methods: HIV-1 polymerase sequences were analysed using the Calibrated Population Resistance tool. Domestic spread of transmitted drug resistance (TDR) was investigated through maximum likelihood and Bayesian approaches.
Results: Among ART-naïve patients, the prevalence of TDR to any of the following classes (NRTIs, NNRTIs and PIs) was 8.5% (95% CI: 4.5%- 15.4%): 6.6% to NRTIs, 0.9% to NNRTIs, and 1.9% to PIs.... (More) - Introduction: Resistance to antiretroviral drugs can complicate the management of HIV-1 infection and impair control of its spread. The aim of the current study was to investigate the prevalence and transmission of HIV-1 drug resistance among 106 antiretroviral therapy (ART)-naïve patients diagnosed in Iceland (1996–2012).
Methods: HIV-1 polymerase sequences were analysed using the Calibrated Population Resistance tool. Domestic spread of transmitted drug resistance (TDR) was investigated through maximum likelihood and Bayesian approaches.
Results: Among ART-naïve patients, the prevalence of TDR to any of the following classes (NRTIs, NNRTIs and PIs) was 8.5% (95% CI: 4.5%- 15.4%): 6.6% to NRTIs, 0.9% to NNRTIs, and 1.9% to PIs. The most frequent NRTI mutation detected was T215C/D (n=7, 5.7%). The only NNRTI mutation detected was K103N (n=1, 0.9%). PI mutations detected were M46I (n=1, 0.9%) and L90M (n=1, 0.9%). Six patients harbouring T215C/D, were linked in a supported phylogenetic cluster. No significant association was found between TDR and demographic or risk groups. Trend analysis showed a decrease in the prevalence of TDR (1996–2012, p=0.003).
Conclusions: TDR prevalence in Iceland was at a moderate level and decreased during 1996-2012. Screening for TDR is recommended to limit its local spread and to optimize HIV-1 therapy. (Less)
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https://lup.lub.lu.se/record/c9561e65-a9b0-4c4d-876a-e55323acc87a
- author
- Sallam, Malik LU ; Özkaya Sahin, Gülsen LU ; Indriðason, Hlynur ; Esbjörnsson, Joakim LU ; Löve, Arthur ; Widell, Anders LU ; Gottfreðsson, Magnús and Medstrand, Patrik LU
- organization
- publishing date
- 2017-06-13
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Phylogeny, Resistance, Trend, Transmission, BEAST
- in
- Infection Ecology and Epidemiology
- volume
- 7
- issue
- 1
- article number
- 1328964
- pages
- 8 pages
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:28649306
- scopus:85048093001
- ISSN
- 2000-8686
- DOI
- 10.1080/20008686.2017.1328964
- language
- English
- LU publication?
- yes
- id
- c9561e65-a9b0-4c4d-876a-e55323acc87a
- date added to LUP
- 2017-06-13 19:43:39
- date last changed
- 2024-01-13 22:50:04
@article{c9561e65-a9b0-4c4d-876a-e55323acc87a, abstract = {{Introduction: Resistance to antiretroviral drugs can complicate the management of HIV-1 infection and impair control of its spread. The aim of the current study was to investigate the prevalence and transmission of HIV-1 drug resistance among 106 antiretroviral therapy (ART)-naïve patients diagnosed in Iceland (1996–2012).<br/>Methods: HIV-1 polymerase sequences were analysed using the Calibrated Population Resistance tool. Domestic spread of transmitted drug resistance (TDR) was investigated through maximum likelihood and Bayesian approaches.<br/>Results: Among ART-naïve patients, the prevalence of TDR to any of the following classes (NRTIs, NNRTIs and PIs) was 8.5% (95% CI: 4.5%- 15.4%): 6.6% to NRTIs, 0.9% to NNRTIs, and 1.9% to PIs. The most frequent NRTI mutation detected was T215C/D (n=7, 5.7%). The only NNRTI mutation detected was K103N (n=1, 0.9%). PI mutations detected were M46I (n=1, 0.9%) and L90M (n=1, 0.9%). Six patients harbouring T215C/D, were linked in a supported phylogenetic cluster. No significant association was found between TDR and demographic or risk groups. Trend analysis showed a decrease in the prevalence of TDR (1996–2012, p=0.003).<br/>Conclusions: TDR prevalence in Iceland was at a moderate level and decreased during 1996-2012. Screening for TDR is recommended to limit its local spread and to optimize HIV-1 therapy.}}, author = {{Sallam, Malik and Özkaya Sahin, Gülsen and Indriðason, Hlynur and Esbjörnsson, Joakim and Löve, Arthur and Widell, Anders and Gottfreðsson, Magnús and Medstrand, Patrik}}, issn = {{2000-8686}}, keywords = {{Phylogeny; Resistance; Trend; Transmission; BEAST}}, language = {{eng}}, month = {{06}}, number = {{1}}, publisher = {{Taylor & Francis}}, series = {{Infection Ecology and Epidemiology}}, title = {{Decreasing prevalence of transmitted drug resistance among ART-naive HIV-1-infected patients in Iceland, 1996–2012}}, url = {{https://lup.lub.lu.se/search/files/28104423/Decreasing_prevalence_of_transmitted_drug_resistance_among_ART_naive_HIV_1_infected_patients_in_Iceland_1996_2012.pdf}}, doi = {{10.1080/20008686.2017.1328964}}, volume = {{7}}, year = {{2017}}, }