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Induction and functional role of type I interferon in bacterial infection of macrophages

Movert, Elin LU (2019) In Lund University, Faculty of Medicine Doctoral Dissertation Series 2019(64).
Abstract
Infection represents an evolutionary arms race between pathogen and host. Thus, scientists find that pathogenic microbes have evolved elegant strategies to manipulate or avoid our immune system, allowing them to persist within the human population. This thesis is largely focused on how bacteria regulate and exploit the type I interferon (IFN) response in infected macrophages – a processes of central importance to cellular immunity and bacterial pathogenesis. More specifically, we have been interested in understanding how Streptococcus pyogenes and mycobacteria – representing evolutionarily distant pathogens causing acute and chronic infections, respectively – interact with macrophages to induce and functionally exploit the type I IFN... (More)
Infection represents an evolutionary arms race between pathogen and host. Thus, scientists find that pathogenic microbes have evolved elegant strategies to manipulate or avoid our immune system, allowing them to persist within the human population. This thesis is largely focused on how bacteria regulate and exploit the type I interferon (IFN) response in infected macrophages – a processes of central importance to cellular immunity and bacterial pathogenesis. More specifically, we have been interested in understanding how Streptococcus pyogenes and mycobacteria – representing evolutionarily distant pathogens causing acute and chronic infections, respectively – interact with macrophages to induce and functionally exploit the type I IFN response. Our studies have identified a specific streptococcal component, the surface M protein, and the mechanisms underlying induction of the type I IFN response in infected macrophages. In the case of mycobacterial infection, we provide new insight into the genetic requirements and mechanisms for ESX-1-mediated type I IFN induction, and describe a macrophage-modulating role for induced type I IFN that can be exploited by the bacteria to avoid being cleared by the immune system. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • professor Ramakrishnan, Lalita, University of Cambridge, Cambridge, United Kingdom
organization
publishing date
type
Thesis
publication status
published
subject
keywords
macrophage, Streptococcal M proteins, Mycobacterium marinum, Type I interferon, Infection
in
Lund University, Faculty of Medicine Doctoral Dissertation Series
volume
2019
issue
64
pages
85 pages
publisher
Lund University: Faculty of Medicine
defense location
Belfragesalen, BMC D15, Klinikgatan 32 i Lund
defense date
2019-05-31 13:00:00
ISSN
1652-8220
ISBN
978-91-7619-793-6
language
English
LU publication?
yes
id
ca205ce5-31ab-4db5-a736-258b7d48f8bb
date added to LUP
2019-05-13 11:46:58
date last changed
2021-07-16 08:18:26
@phdthesis{ca205ce5-31ab-4db5-a736-258b7d48f8bb,
  abstract     = {{Infection represents an evolutionary arms race between pathogen and host. Thus, scientists find that pathogenic microbes have evolved elegant strategies to manipulate or avoid our immune system, allowing them to persist within the human population. This thesis is largely focused on how bacteria regulate and exploit the type I interferon (IFN) response in infected macrophages – a processes of central importance to cellular immunity and bacterial pathogenesis. More specifically, we have been interested in understanding how Streptococcus pyogenes and mycobacteria – representing evolutionarily distant pathogens causing acute and chronic infections, respectively – interact with macrophages to induce and functionally exploit the type I IFN response. Our studies have identified a specific streptococcal component, the surface M protein, and the mechanisms underlying induction of the type I IFN response in infected macrophages. In the case of mycobacterial infection, we provide new insight into the genetic requirements and mechanisms for ESX-1-mediated type I IFN induction, and describe a macrophage-modulating role for induced type I IFN that can be exploited by the bacteria to avoid being cleared by the immune system.}},
  author       = {{Movert, Elin}},
  isbn         = {{978-91-7619-793-6}},
  issn         = {{1652-8220}},
  keywords     = {{macrophage; Streptococcal M proteins; Mycobacterium marinum; Type I interferon; Infection}},
  language     = {{eng}},
  number       = {{64}},
  publisher    = {{Lund University: Faculty of Medicine}},
  school       = {{Lund University}},
  series       = {{Lund University, Faculty of Medicine Doctoral Dissertation Series}},
  title        = {{Induction and functional role of type I interferon in bacterial infection of macrophages}},
  url          = {{https://lup.lub.lu.se/search/files/64158886/Elin_Movert_WEBB_Media_tryck.pdf}},
  volume       = {{2019}},
  year         = {{2019}},
}