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Predictors of Mortality and Cardiovascular Outcome at 6 Months after Hospitalization for COVID-19

Renda, Giulia ; Ricci, Fabrizio LU ; Spinoni, Enrico Guido ; Grisafi, Leonardo ; D’ardes, Damiano ; Mennuni, Marco ; Tana, Claudio ; Rognoni, Andrea ; Bellan, Mattia and Sainaghi, Pier Paolo , et al. (2022) In Journal of Clinical Medicine 11(3).
Abstract

Clinical outcome data of patients discharged after Coronavirus disease 2019 (COVID-19) are limited and no study has evaluated predictors of cardiovascular prognosis in this setting. Our aim was to assess short-term mortality and cardiovascular outcome after hospitalization for COVID-19. A prospective cohort of 296 consecutive patients discharged after COVID-19 from two Italian institutions during the first wave of the pandemic and followed up to 6 months was included. The primary endpoint was all-cause mortality. The co-primary endpoint was the incidence of the composite outcome of major adverse cardiac and cerebrovascular events (MACCE: cardiovascular death, myocardial infarction, stroke, pulmonary embolism, acute heart failure, or... (More)

Clinical outcome data of patients discharged after Coronavirus disease 2019 (COVID-19) are limited and no study has evaluated predictors of cardiovascular prognosis in this setting. Our aim was to assess short-term mortality and cardiovascular outcome after hospitalization for COVID-19. A prospective cohort of 296 consecutive patients discharged after COVID-19 from two Italian institutions during the first wave of the pandemic and followed up to 6 months was included. The primary endpoint was all-cause mortality. The co-primary endpoint was the incidence of the composite outcome of major adverse cardiac and cerebrovascular events (MACCE: cardiovascular death, myocardial infarction, stroke, pulmonary embolism, acute heart failure, or hospitalization for cardiovascular causes). The mean follow-up duration was 6 ± 2 months. The incidence of all-cause death was 4.7%. At multivariate analysis, age was the only independent predictor of mortality (aHR 1.08, 95% CI 1.01–1.16). MACCE occurred in 7.2% of patients. After adjustment, female sex (aHR 2.6, 95% CI 1.05–6.52), in-hospital acute heart failure during index hospitalization (aHR 3.45, 95% CI 1.19–10), and prevalent atrial fibrillation (aHR 3.05, 95% CI 1.13–8.24) significantly predicted the incident risk of MACCE. These findings may help to identify patients for whom a closer and more accurate surveillance after discharge for COVID-19 should be considered.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiovascular events, COVID-19, Follow-up, Mortality
in
Journal of Clinical Medicine
volume
11
issue
3
article number
729
publisher
MDPI AG
external identifiers
  • pmid:35160182
  • scopus:85123555658
ISSN
2077-0383
DOI
10.3390/jcm11030729
language
English
LU publication?
yes
id
caf1c9da-41af-4777-b059-a4bca0214c18
date added to LUP
2022-03-28 10:49:59
date last changed
2024-05-06 20:29:08
@article{caf1c9da-41af-4777-b059-a4bca0214c18,
  abstract     = {{<p>Clinical outcome data of patients discharged after Coronavirus disease 2019 (COVID-19) are limited and no study has evaluated predictors of cardiovascular prognosis in this setting. Our aim was to assess short-term mortality and cardiovascular outcome after hospitalization for COVID-19. A prospective cohort of 296 consecutive patients discharged after COVID-19 from two Italian institutions during the first wave of the pandemic and followed up to 6 months was included. The primary endpoint was all-cause mortality. The co-primary endpoint was the incidence of the composite outcome of major adverse cardiac and cerebrovascular events (MACCE: cardiovascular death, myocardial infarction, stroke, pulmonary embolism, acute heart failure, or hospitalization for cardiovascular causes). The mean follow-up duration was 6 ± 2 months. The incidence of all-cause death was 4.7%. At multivariate analysis, age was the only independent predictor of mortality (aHR 1.08, 95% CI 1.01–1.16). MACCE occurred in 7.2% of patients. After adjustment, female sex (aHR 2.6, 95% CI 1.05–6.52), in-hospital acute heart failure during index hospitalization (aHR 3.45, 95% CI 1.19–10), and prevalent atrial fibrillation (aHR 3.05, 95% CI 1.13–8.24) significantly predicted the incident risk of MACCE. These findings may help to identify patients for whom a closer and more accurate surveillance after discharge for COVID-19 should be considered.</p>}},
  author       = {{Renda, Giulia and Ricci, Fabrizio and Spinoni, Enrico Guido and Grisafi, Leonardo and D’ardes, Damiano and Mennuni, Marco and Tana, Claudio and Rognoni, Andrea and Bellan, Mattia and Sainaghi, Pier Paolo and Pirisi, Mario and De Vecchi, Simona and Gallina, Sabina and Pierdomenico, Sante Donato and Cipollone, Francesco and Patti, Giuseppe}},
  issn         = {{2077-0383}},
  keywords     = {{Cardiovascular events; COVID-19; Follow-up; Mortality}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{3}},
  publisher    = {{MDPI AG}},
  series       = {{Journal of Clinical Medicine}},
  title        = {{Predictors of Mortality and Cardiovascular Outcome at 6 Months after Hospitalization for COVID-19}},
  url          = {{http://dx.doi.org/10.3390/jcm11030729}},
  doi          = {{10.3390/jcm11030729}},
  volume       = {{11}},
  year         = {{2022}},
}