Bayesian determination of the effect of a deep eutectic solvent on the structure of lipid monolayers
(2019) In Physical Chemistry Chemical Physics 21(11). p.6133-6141- Abstract
In this work, we present the first example of the self-assembly of phospholipid monolayers at the interface between air and an ionic solvent. Deep eutectic solvents are a novel class of environmentally friendly, non-aqueous, room temperature liquids with tunable properties, that have wide-ranging potential applications and are capable of promoting the self-assembly of surfactant molecules. We use a chemically-consistent Bayesian modelling of X-ray and neutron reflectometry measurements to show that these monolayers broadly behave as they do on water. This method allows for the monolayer structure to be determined, alongside the molecular volumes of the individual monolayer components, without the need for water-specific constraints to... (More)
In this work, we present the first example of the self-assembly of phospholipid monolayers at the interface between air and an ionic solvent. Deep eutectic solvents are a novel class of environmentally friendly, non-aqueous, room temperature liquids with tunable properties, that have wide-ranging potential applications and are capable of promoting the self-assembly of surfactant molecules. We use a chemically-consistent Bayesian modelling of X-ray and neutron reflectometry measurements to show that these monolayers broadly behave as they do on water. This method allows for the monolayer structure to be determined, alongside the molecular volumes of the individual monolayer components, without the need for water-specific constraints to be introduced. Furthermore, using this method we are able to better understand the correlations present between parameters in the analytical model. This example of a non-aqueous phospholipid monolayer has important implications for the potential uses of these solvents and for our understanding of how biomolecules behave in the absence of water.
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- author
- McCluskey, Andrew R. ; Sanchez-Fernandez, Adrian LU ; Edler, Karen J. LU ; Parker, Stephen C. ; Jackson, Andrew J. LU ; Campbell, Richard A. LU and Arnold, Thomas
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physical Chemistry Chemical Physics
- volume
- 21
- issue
- 11
- pages
- 9 pages
- publisher
- Royal Society of Chemistry
- external identifiers
-
- scopus:85062888640
- pmid:30816891
- ISSN
- 1463-9076
- DOI
- 10.1039/c9cp00203k
- language
- English
- LU publication?
- yes
- id
- cbd9a384-c00f-4cdb-9434-cf75642632b1
- date added to LUP
- 2019-03-29 12:33:00
- date last changed
- 2024-07-09 08:41:06
@article{cbd9a384-c00f-4cdb-9434-cf75642632b1, abstract = {{<p>In this work, we present the first example of the self-assembly of phospholipid monolayers at the interface between air and an ionic solvent. Deep eutectic solvents are a novel class of environmentally friendly, non-aqueous, room temperature liquids with tunable properties, that have wide-ranging potential applications and are capable of promoting the self-assembly of surfactant molecules. We use a chemically-consistent Bayesian modelling of X-ray and neutron reflectometry measurements to show that these monolayers broadly behave as they do on water. This method allows for the monolayer structure to be determined, alongside the molecular volumes of the individual monolayer components, without the need for water-specific constraints to be introduced. Furthermore, using this method we are able to better understand the correlations present between parameters in the analytical model. This example of a non-aqueous phospholipid monolayer has important implications for the potential uses of these solvents and for our understanding of how biomolecules behave in the absence of water.</p>}}, author = {{McCluskey, Andrew R. and Sanchez-Fernandez, Adrian and Edler, Karen J. and Parker, Stephen C. and Jackson, Andrew J. and Campbell, Richard A. and Arnold, Thomas}}, issn = {{1463-9076}}, language = {{eng}}, number = {{11}}, pages = {{6133--6141}}, publisher = {{Royal Society of Chemistry}}, series = {{Physical Chemistry Chemical Physics}}, title = {{Bayesian determination of the effect of a deep eutectic solvent on the structure of lipid monolayers}}, url = {{http://dx.doi.org/10.1039/c9cp00203k}}, doi = {{10.1039/c9cp00203k}}, volume = {{21}}, year = {{2019}}, }