Endoplasmic reticulum stress regulation in hematopoietic stem cells
(2016) In [Rinsho ketsueki] The Japanese journal of clinical hematology 57(8). p.1052-1058- Abstract
Adult hematopoietic stem cells (HSCs) reside in bone marrow and are maintained in a dormant state within a special microenvironment, their so-called "niche". Detaching from the niche induces cell cycle progression, resulting in a reduction of the reconstitution capacity of HSCs. In contrast, fetal liver HSCs actively divide without losing their stem cell potentials. Thus, it has been unclear what types of cellular responses and metabolic changes occur in growing HSCs. We previously discovered that HSCs express relatively low levels of endoplasmic reticulum (ER) chaperone proteins governing protein folding, making HSCs vulnerable to an elevation of stress signals caused by accumulation of un-/misfolded proteins (ER stress) upon in vitro... (More)
Adult hematopoietic stem cells (HSCs) reside in bone marrow and are maintained in a dormant state within a special microenvironment, their so-called "niche". Detaching from the niche induces cell cycle progression, resulting in a reduction of the reconstitution capacity of HSCs. In contrast, fetal liver HSCs actively divide without losing their stem cell potentials. Thus, it has been unclear what types of cellular responses and metabolic changes occur in growing HSCs. We previously discovered that HSCs express relatively low levels of endoplasmic reticulum (ER) chaperone proteins governing protein folding, making HSCs vulnerable to an elevation of stress signals caused by accumulation of un-/misfolded proteins (ER stress) upon in vitro culture. Interestingly, fetal liver HSCs do not show ER stress elevation despite unchanged levels of chaperone proteins. Our latest studies utilizing multiple mouse models revealed that in the fetal liver bile acids as chemical chaperones play a key role supporting the protein folding which results in the suppression of ER stress induction. These findings highlight the importance of ER stress regulations in hematopoiesis.
(Less)
- author
- Miharada, Kenichi LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- [Rinsho ketsueki] The Japanese journal of clinical hematology
- volume
- 57
- issue
- 8
- pages
- 7 pages
- publisher
- Nihon Rinsho Ketsueki Gakkai/Japan Society of Clinical Hematology
- external identifiers
-
- pmid:27599423
- scopus:85011982635
- ISSN
- 0485-1439
- DOI
- 10.11406/rinketsu.57.1052
- language
- English
- LU publication?
- yes
- id
- d2cea125-beee-4e9c-8a45-fc667e6e8abf
- date added to LUP
- 2017-03-03 13:26:28
- date last changed
- 2024-07-07 13:46:24
@article{d2cea125-beee-4e9c-8a45-fc667e6e8abf,
abstract = {{<p>Adult hematopoietic stem cells (HSCs) reside in bone marrow and are maintained in a dormant state within a special microenvironment, their so-called "niche". Detaching from the niche induces cell cycle progression, resulting in a reduction of the reconstitution capacity of HSCs. In contrast, fetal liver HSCs actively divide without losing their stem cell potentials. Thus, it has been unclear what types of cellular responses and metabolic changes occur in growing HSCs. We previously discovered that HSCs express relatively low levels of endoplasmic reticulum (ER) chaperone proteins governing protein folding, making HSCs vulnerable to an elevation of stress signals caused by accumulation of un-/misfolded proteins (ER stress) upon in vitro culture. Interestingly, fetal liver HSCs do not show ER stress elevation despite unchanged levels of chaperone proteins. Our latest studies utilizing multiple mouse models revealed that in the fetal liver bile acids as chemical chaperones play a key role supporting the protein folding which results in the suppression of ER stress induction. These findings highlight the importance of ER stress regulations in hematopoiesis. </p>}},
author = {{Miharada, Kenichi}},
issn = {{0485-1439}},
language = {{eng}},
number = {{8}},
pages = {{1052--1058}},
publisher = {{Nihon Rinsho Ketsueki Gakkai/Japan Society of Clinical Hematology}},
series = {{[Rinsho ketsueki] The Japanese journal of clinical hematology}},
title = {{Endoplasmic reticulum stress regulation in hematopoietic stem cells}},
url = {{http://dx.doi.org/10.11406/rinketsu.57.1052}},
doi = {{10.11406/rinketsu.57.1052}},
volume = {{57}},
year = {{2016}},
}