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Islet microRNAs in health and type-2 diabetes

Wendt, Anna LU ; Esguerra, Jonathan LS LU orcid and Eliasson, Lena LU orcid (2018) In Current Opinion in Pharmacology 43. p.46-52
Abstract

Failure of the β-cell to secrete enough insulin is a major contributing factor in the pathogenesis of type-2 diabetes (T2D). MicroRNAs provide an extra layer in the regulation of protein expression, and are thus involved in β-cell compensation during development of the disease. In this review, we discuss how microRNAs can regulate their target protein expression and phenotypic output, present the status of nutritional regulation of microRNA expression, and summarize work on microRNA expression in human islets. In conclusion, current data lend support to microRNAs being essential regulators of insulin secretion. Future work will describe microRNAs in α-cell function, details of the microRNA–mRNA network, and possibilities to use... (More)

Failure of the β-cell to secrete enough insulin is a major contributing factor in the pathogenesis of type-2 diabetes (T2D). MicroRNAs provide an extra layer in the regulation of protein expression, and are thus involved in β-cell compensation during development of the disease. In this review, we discuss how microRNAs can regulate their target protein expression and phenotypic output, present the status of nutritional regulation of microRNA expression, and summarize work on microRNA expression in human islets. In conclusion, current data lend support to microRNAs being essential regulators of insulin secretion. Future work will describe microRNAs in α-cell function, details of the microRNA–mRNA network, and possibilities to use microRNAs as biomarkers and in therapeutic treatment of T2D and complications.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Pharmacology
volume
43
pages
7 pages
publisher
Elsevier
external identifiers
  • pmid:30144686
  • scopus:85051832801
ISSN
1471-4892
DOI
10.1016/j.coph.2018.08.003
language
English
LU publication?
yes
id
d44f1755-1f23-46ef-bb9b-2fa5c7a50f43
date added to LUP
2018-09-05 14:24:47
date last changed
2024-05-27 15:58:34
@article{d44f1755-1f23-46ef-bb9b-2fa5c7a50f43,
  abstract     = {{<p>Failure of the β-cell to secrete enough insulin is a major contributing factor in the pathogenesis of type-2 diabetes (T2D). MicroRNAs provide an extra layer in the regulation of protein expression, and are thus involved in β-cell compensation during development of the disease. In this review, we discuss how microRNAs can regulate their target protein expression and phenotypic output, present the status of nutritional regulation of microRNA expression, and summarize work on microRNA expression in human islets. In conclusion, current data lend support to microRNAs being essential regulators of insulin secretion. Future work will describe microRNAs in α-cell function, details of the microRNA–mRNA network, and possibilities to use microRNAs as biomarkers and in therapeutic treatment of T2D and complications.</p>}},
  author       = {{Wendt, Anna and Esguerra, Jonathan LS and Eliasson, Lena}},
  issn         = {{1471-4892}},
  language     = {{eng}},
  month        = {{12}},
  pages        = {{46--52}},
  publisher    = {{Elsevier}},
  series       = {{Current Opinion in Pharmacology}},
  title        = {{Islet microRNAs in health and type-2 diabetes}},
  url          = {{http://dx.doi.org/10.1016/j.coph.2018.08.003}},
  doi          = {{10.1016/j.coph.2018.08.003}},
  volume       = {{43}},
  year         = {{2018}},
}