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Carotid Plaque Morphology is Similar in Patients with Reduced and Normal Renal Function

Heijl, Caroline LU ; Kahn, Fredrik LU ; Edsfeldt, Andreas LU ; Tengryd, Christoffer LU ; Nilsson, Jan LU and Goncalves, Isabel LU orcid (2020) In Clinical Medicine Insights: Cardiology 14.
Abstract

Background: Chronic Kidney Disease (CKD) is associated with an increased risk for cardiovascular events such as stroke. However, it is still unclear if decreased kidney function is associated with a vulnerable atherosclerotic plaque phenotype. To explore if renal function was associated with carotid plaque vulnerability we analyzed carotid plaques obtained at surgery from the Carotid Plaque Imaging Project (CPIP). Methods: Patients were enrolled through the CPIP cohort. The indication for surgery was plaques with stenosis >70%, associated with ipsilateral symptoms or plaques with stenosis >80% not associated with symptoms. Transversal sections from the most stenotic plaque region were analyzed for connective tissue, calcium,... (More)

Background: Chronic Kidney Disease (CKD) is associated with an increased risk for cardiovascular events such as stroke. However, it is still unclear if decreased kidney function is associated with a vulnerable atherosclerotic plaque phenotype. To explore if renal function was associated with carotid plaque vulnerability we analyzed carotid plaques obtained at surgery from the Carotid Plaque Imaging Project (CPIP). Methods: Patients were enrolled through the CPIP cohort. The indication for surgery was plaques with stenosis >70%, associated with ipsilateral symptoms or plaques with stenosis >80% not associated with symptoms. Transversal sections from the most stenotic plaque region were analyzed for connective tissue, calcium, lipids, macrophages, intraplaque hemorrhage, and smooth muscle cells. Homogenates were analyzed for collagen and elastin. Results: Carotid endarterectomy specimens from 379 patients were obtained. The median GFR was 73 ml/min/1.73 m2. Plaque characteristics showed no significant association with eGFR, neither when eGFR was divided in CKD groups nor when eGFR was handled as a continuous variable and adjusting for other known risk factors (ie, age, diabetes, hypertension, and smoking). Conclusions: The higher risk of cardiovascular disease such as stroke in CKD is not associated with increased plaque vulnerability and other factors have to be sought.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atherosclerosis, cardiovascular disease, chronic kidney disease, stroke
in
Clinical Medicine Insights: Cardiology
volume
14
publisher
SAGE Publications
external identifiers
  • scopus:85089836130
  • pmid:32922111
ISSN
1179-5468
DOI
10.1177/1179546820951793
language
English
LU publication?
yes
id
df302bef-fcae-49e1-92c4-c2ed740f0839
date added to LUP
2020-09-08 14:35:58
date last changed
2024-04-03 14:12:01
@article{df302bef-fcae-49e1-92c4-c2ed740f0839,
  abstract     = {{<p>Background: Chronic Kidney Disease (CKD) is associated with an increased risk for cardiovascular events such as stroke. However, it is still unclear if decreased kidney function is associated with a vulnerable atherosclerotic plaque phenotype. To explore if renal function was associated with carotid plaque vulnerability we analyzed carotid plaques obtained at surgery from the Carotid Plaque Imaging Project (CPIP). Methods: Patients were enrolled through the CPIP cohort. The indication for surgery was plaques with stenosis &gt;70%, associated with ipsilateral symptoms or plaques with stenosis &gt;80% not associated with symptoms. Transversal sections from the most stenotic plaque region were analyzed for connective tissue, calcium, lipids, macrophages, intraplaque hemorrhage, and smooth muscle cells. Homogenates were analyzed for collagen and elastin. Results: Carotid endarterectomy specimens from 379 patients were obtained. The median GFR was 73 ml/min/1.73 m<sup>2</sup>. Plaque characteristics showed no significant association with eGFR, neither when eGFR was divided in CKD groups nor when eGFR was handled as a continuous variable and adjusting for other known risk factors (ie, age, diabetes, hypertension, and smoking). Conclusions: The higher risk of cardiovascular disease such as stroke in CKD is not associated with increased plaque vulnerability and other factors have to be sought.</p>}},
  author       = {{Heijl, Caroline and Kahn, Fredrik and Edsfeldt, Andreas and Tengryd, Christoffer and Nilsson, Jan and Goncalves, Isabel}},
  issn         = {{1179-5468}},
  keywords     = {{Atherosclerosis; cardiovascular disease; chronic kidney disease; stroke}},
  language     = {{eng}},
  publisher    = {{SAGE Publications}},
  series       = {{Clinical Medicine Insights: Cardiology}},
  title        = {{Carotid Plaque Morphology is Similar in Patients with Reduced and Normal Renal Function}},
  url          = {{http://dx.doi.org/10.1177/1179546820951793}},
  doi          = {{10.1177/1179546820951793}},
  volume       = {{14}},
  year         = {{2020}},
}