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Traffic-Related Air Pollution as a Risk Factor for Dementia : No Clear Modifying Effects of APOE ϵ4 in the Betula Cohort

Oudin, Anna LU ; Andersson, John ; Sundström, Anna ; Adolfsson, Annelie Nordin ; Åström, Daniel Oudin LU ; Adolfsson, Rolf ; Forsberg, Bertil and Nordin, Maria (2021) In Advances in Alzheimer's Disease 8. p.357-364
Abstract

It is widely known that the apolipoprotein E (APOE) ϵ4 allele imposes a higher risk for Alzheimer's disease (AD). Recent evidence suggests that exposure to air pollution is also a risk factor for AD, and results from a few studies indicate that the effect of air pollution on cognitive function and dementia is stronger in APOE ϵ4 carriers than in non-carriers. Air pollution and interaction with APOE ϵ4 on AD risk thus merits further attention. We studied dementia incidence over a 15-year period from the longitudinal Betula study in Northern Sweden. As a marker for long-term exposure to traffic-related air pollution, we used modelled annual mean nitrogen oxide levels at the residential address of the participants at start of follow-up.... (More)

It is widely known that the apolipoprotein E (APOE) ϵ4 allele imposes a higher risk for Alzheimer's disease (AD). Recent evidence suggests that exposure to air pollution is also a risk factor for AD, and results from a few studies indicate that the effect of air pollution on cognitive function and dementia is stronger in APOE ϵ4 carriers than in non-carriers. Air pollution and interaction with APOE ϵ4 on AD risk thus merits further attention. We studied dementia incidence over a 15-year period from the longitudinal Betula study in Northern Sweden. As a marker for long-term exposure to traffic-related air pollution, we used modelled annual mean nitrogen oxide levels at the residential address of the participants at start of follow-up. Nitrogen oxide correlate well with fine particulate air pollution levels in the study area. We had full data on air pollution, incidence of AD and vascular dementia (VaD), APOE ϵ4 carrier status, and relevant confounding factors for 1,567 participants. As expected, air pollution was rather clearly associated with dementia incidence. However, there was no evidence for a modifying effect by APOE ϵ4 on the association (p-value for interaction > 0.30 for both total dementia (AD+VaD) and AD). The results from this study do not imply that adverse effects of air pollution on dementia incidence is limited to, or stronger in, APOE ϵ4 carriers than in the total population.

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author
; ; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Air pollution, Alzheimer's disease, apolipoprotein E, dementia
host publication
Alzheimer’s Disease and Air Pollution
series title
Advances in Alzheimer's Disease
volume
8
pages
8 pages
external identifiers
  • scopus:85110853331
  • scopus:85105025060
ISSN
2210-5727
ISBN
978-1-64368-158-0
978-1-64368-159-7
DOI
10.3233/AIAD210029
project
How is our health affected by particles from wood burning?
language
English
LU publication?
yes
id
df72c8a9-c36a-4801-a790-ef9fbcbf809b
date added to LUP
2021-06-01 14:49:39
date last changed
2024-06-01 11:30:15
@inbook{df72c8a9-c36a-4801-a790-ef9fbcbf809b,
  abstract     = {{<p>It is widely known that the apolipoprotein E (APOE) ϵ4 allele imposes a higher risk for Alzheimer's disease (AD). Recent evidence suggests that exposure to air pollution is also a risk factor for AD, and results from a few studies indicate that the effect of air pollution on cognitive function and dementia is stronger in APOE ϵ4 carriers than in non-carriers. Air pollution and interaction with APOE ϵ4 on AD risk thus merits further attention. We studied dementia incidence over a 15-year period from the longitudinal Betula study in Northern Sweden. As a marker for long-term exposure to traffic-related air pollution, we used modelled annual mean nitrogen oxide levels at the residential address of the participants at start of follow-up. Nitrogen oxide correlate well with fine particulate air pollution levels in the study area. We had full data on air pollution, incidence of AD and vascular dementia (VaD), APOE ϵ4 carrier status, and relevant confounding factors for 1,567 participants. As expected, air pollution was rather clearly associated with dementia incidence. However, there was no evidence for a modifying effect by APOE ϵ4 on the association (p-value for interaction &gt; 0.30 for both total dementia (AD+VaD) and AD). The results from this study do not imply that adverse effects of air pollution on dementia incidence is limited to, or stronger in, APOE ϵ4 carriers than in the total population.</p>}},
  author       = {{Oudin, Anna and Andersson, John and Sundström, Anna and Adolfsson, Annelie Nordin and Åström, Daniel Oudin and Adolfsson, Rolf and Forsberg, Bertil and Nordin, Maria}},
  booktitle    = {{Alzheimer’s Disease and Air Pollution}},
  isbn         = {{978-1-64368-158-0}},
  issn         = {{2210-5727}},
  keywords     = {{Air pollution; Alzheimer's disease; apolipoprotein E; dementia}},
  language     = {{eng}},
  pages        = {{357--364}},
  series       = {{Advances in Alzheimer's Disease}},
  title        = {{Traffic-Related Air Pollution as a Risk Factor for Dementia : No Clear Modifying Effects of APOE ϵ4 in the Betula Cohort}},
  url          = {{http://dx.doi.org/10.3233/AIAD210029}},
  doi          = {{10.3233/AIAD210029}},
  volume       = {{8}},
  year         = {{2021}},
}